公开(公告)号：EP0775007A4

公开(公告)日：1998-03-25

申请号：EP96916681

申请日：1996-05-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  ELLIS DALE R

IPC: G01N33/48 ,  A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B1/06 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC classification number: A61M1/0209 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/003 ,  B01D21/0087 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  A61M2202/0071

Abstract: A chamber for rotation about a rotational axis to separate blood components includes first and second spaced apart side walls forming a separation zone. Blood conveyed into the separation zone separates into a first region of cellular components, a second region of plasma, and an interface region between the first and second regions. An outlet conveys the second region of plasma from the separation zone. An interior wall extends into the separation zone to permit passage of the second region of plasma to the outlet while retarding passage of the interface region and the first region of cellular components to the outlet. The tapered second surface has a major axis that is oriented at a non-parallel angle with respect to the axis of the outlet. Due to this orientation, the boundary between the interface region and the other two regions is held uniform along the tapered surface. The boundary does not bulge to spill materials in the first interface region or interface region over the first surface and into the constricted passage. As a result, the second region of plasma is kept essentially free of other materials.

公开(公告)号：EP0618829A4

公开(公告)日：1995-09-20

申请号：EP93909183

申请日：1993-03-23

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T

IPC: A61M1/02 ,  A61M1/30 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04

CPC classification number: B04B5/0442 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10

Abstract: A system (234) for monitoring the interface region between cellular constituents and plasma in a blood separation chamber (80) employs a sensor mechanism (236) for emitting upon the interface region energy that is absorbed by the cellular constituents. The sensor mechanism (244) also detects the intensity of the energy that is not absorbed by the interface region to generate an unabsorbed intensity output signal. The system (234) moves the interface region relative to the sensor mechanism during a prescribed time period. A first circuit (268) measures variations in the unabsorbed intensity output signal over the prescribed time period and generates a time based output. A second circuit (270) can derive the physical size of the interface region based upon the time based output.

公开(公告)号：EP1015089A4

公开(公告)日：2000-12-20

申请号：EP98930444

申请日：1998-06-22

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  MIN KYUNGYOON ,  SAHLIN MARK

IPC: G01N33/49 ,  A61B5/145 ,  A61K35/14 ,  A61M1/02 ,  A61M1/36 ,  A61P7/00 ,  B01D17/02 ,  B01D17/12 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/35

CPC classification number: B01D17/0217 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  B01D21/003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/32 ,  B01D2221/10 ,  B04B5/0442 ,  B04B13/00 ,  A61M2202/0071

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates a third output based, at least in part, upon the integrated output, which comprises parameters for storing the platelet volume.

公开(公告)号：EP0301077A4

公开(公告)日：1990-03-12

申请号：EP88902011

申请日：1988-01-29

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  CERNY DAVID E ,  FOLEY JOHN T ,  WEST JOSEPH C JR

IPC: A61M1/02 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04

CPC classification number: B04B5/0442 ,  A61M2205/15 ,  B04B5/0428 ,  B04B2005/045

Abstract: An apparatus and method of separating a component from a collected quantity of fluid. The apparatus (10) includes a dual member centrifuge (12) and an associated fluid flow transfer set (14). The transfer set (14) has a collection container (44) in which a quantity of fluid can be initially accumulated. The collection container (44) is formed as a disk-shaped plastic member with an elongated generally radially extending barrier member formed therein. A component collection container (64) is in fluid flow communication with the disk-shaped container. The method provides for centrifugation of the collection container (44) in the dual member centrifuge (12) thereby separating out the selected fluid component. The component can then be pumped out of the collection container (44) into the component accumulation container (64). The residual fluid can be sealed in the collection container for later use. The component collection container can be separated and sealed also for later use.

公开(公告)号：EP1229978A4

公开(公告)日：2005-12-14

申请号：EP00972096

申请日：2000-10-12

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  PATNO TIMOTHY J

IPC: G01N33/49 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/59 ,  B01D17/12

CPC classification number: B01D21/26 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/50 ,  B01D17/0217 ,  B01D21/0003 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D21/32 ,  B01D2221/08 ,  B01D2221/10 ,  B04B5/0442 ,  B04B13/00 ,  A61M2202/0071

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates an output based, at least in part, upon the integrated output, which comprises a value indicating a blood volume that needs be processed to obtain a desired platelet volume.

公开(公告)号：EP0684763A4

公开(公告)日：1996-06-26

申请号：EP95904869

申请日：1994-12-09

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  A61K39/12 ,  A61M5/14 ,  A61M37/00 ,  B01D15/04

CPC classification number: A61M1/0209 ,  A61L2/0088 ,  A61M1/0218 ,  A61M1/3686 ,  A61M1/3687

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein comprising the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.

公开(公告)号：EP0623044A4

公开(公告)日：1995-03-08

申请号：EP93912086

申请日：1993-03-23

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T

IPC: A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  G01D5/347 ,  G01D5/34

CPC classification number: B01D21/262 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3696 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  G01D5/34715

Abstract: System transmit a control signal between a rotating element and a stationary element of a blood separation centrifuge (78). An interface control system (234) mounts the element that views the interface on a rotating element of the centrifuge. The interface control system (234) includes a light source (236) and a light detector (244) on a viewing head (238) and a data link (278) for transmitting light intensity signals from the viewing head (238) to an interface control circuit (270) on the stationary frame of the centrifuge (78). The data link (278) includes an intensity control circuit (252) which adjusts the input to the light source (236) and a second light source (254).

公开(公告)号：EP0299054A4

公开(公告)日：1990-03-12

申请号：EP88901722

申请日：1988-01-29

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  SMITH SIDNEY ,  CERNY DAVID E ,  FOLEY JOHN T

IPC: A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/00 ,  B04B5/04 ,  B04B7/08 ,  B04B11/04 ,  B04B13/00 ,  G01D5/347

CPC classification number: B01D17/0217 ,  A61M1/025 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3496 ,  A61M1/3603 ,  A61M1/3681 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  B04B2005/045 ,  G01D5/34715 ,  A61M2202/0071

Abstract: The apparatus comprises an elongate, flexible separation chamber (51) receivable in a slot (46) of a rotor, so that rotation of the rotor causes separation of a fluid, supplied through an inlet port (51a) to the chamber (51), in regions (104,106) along opposite walls (50d,50e) of the chamber. Each component is removed through a corresponding outlet port (51b,51c). One of the outlet ports (51c) is arranged adjacent to the inlet port (51a) and a ramp (111) is provided or formed in the chamber (51) to direct flow of the respective component towards that outlet in a direction opposite to the direction of fluid flow through the inlet.

Abstract translation: 该装置包括可接收在转子的槽（46）中的细长的柔性分离室（51），使得转子的旋转导致通过入口（51a）供应到腔室（51）的流体分离， 沿着腔室的相对壁（50d，50e）的区域（104,106）。 通过相应的出口（51b，51c）去除每个部件。 出口（51c）中的一个布置成邻近入口（51a）并且在室（51）中设置或形成斜面（111），以引导相应部件朝向与该 流体流过入口的方向。

公开(公告)号：AU768997B2

公开(公告)日：2004-01-15

申请号：AU1081001

申请日：2000-10-12

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  PATNO TIMOTHY J

IPC: G01N33/49 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/59 ,  B01D17/12

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates an output based, at least in part, upon the integrated output, which comprises a value indicating a blood volume that needs be processed to obtain a desired platelet volume.

公开(公告)号：BR0014801A

公开(公告)日：2002-06-11

申请号：BR0014801

申请日：2000-10-12

Applicant: BAXTER INT

Inventor： BROWN RICHARD I ,  FOLEY JOHN T ,  PATNO TIMOTHY J

IPC: G01N33/49 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  G01N21/59 ,  B01D17/12

Abstract: Blood processing systems and methods separate blood into constituents including a plasma constituent that includes a platelet volume. The systems and methods detect the optical density of the plasma constituent and generate a first output indicative of the optical density. A processing element integrates the first output relative to the volume of plasma constituent and generates an integrated output. The integrated output correlates to the platelet volume. A second processing element generates an output based, at least in part, upon the integrated output, which comprises a value indicating a blood volume that needs be processed to obtain a desired platelet volume.