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    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    2.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152A1

    公开(公告)日：2014-06-26

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    3.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152C

    公开(公告)日：2018-07-24

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

    Soluto de ectoína compatible así como derivados del mismo para estabilización enzimática
    4.
    发明专利
    Soluto de ectoína compatible así como derivados del mismo para estabilización enzimática 未知

    公开(公告)号：ES2606862T3

    公开(公告)日：2017-03-28

    申请号：ES13707185

    申请日：2013-03-05

    Applicant: HOFFMANN LA ROCHE

    Inventor： CHEMNITIUS GABRIELE ,  GAA OTTO ,  NAGEL THOMAS ,  RECHT KARL

    IPC: C12Q1/32

    Abstract: Una composición seca que comprende los componentes: (a) una deshidrogenasa; (b) un cofactor redox; (c) un agente capaz de inducir un cambio en al menos una propiedad óptica de un reactivo indicador en presencia de equivalentes redox; (d) un reactivo indicador; y (e) al menos un soluto compatible que es ectoína o un derivado de la misma, en la que dicha deshidrogenasa es una glucosa deshidrogenasa y en la que dicho derivado de ectoína se selecciona entre el grupo que consiste en: hidroxiectoína, homoectoína, un éster de hidroxiectoína, un éter de hidroxiectoína, un derivado de sulfonilo de ectoína o un derivado de sulfonilo esterificado de ectoína y una amida de un derivado de sulfonilo de ectoína.

    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION
    6.
    发明专利
    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 未知

    公开(公告)号：CA2861054A1

    公开(公告)日：2013-09-12

    申请号：CA2861054

    申请日：2013-03-05

    Applicant: HOFFMANN LA ROCHE

    Inventor： CHEMNITIUS GABRIELE ,  GAA OTTO ,  NAGEL THOMAS ,  RECHT KARL

    IPC: C12Q1/32

    Abstract: The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.

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