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1.发明专利
公开(公告)号：JP2013003585A
公开(公告)日：2013-01-07
申请号：JP2012133714
申请日：2012-06-13
Inventor： KNEBEL WERNER , ULRICH HEINRICH
IPC: G02B21/06
CPC classification number: G02B21/367 , G02B21/0032 , G02B21/0076 , G02B21/10 , G02B21/16
Abstract: PROBLEM TO BE SOLVED: To improve a scanning microscope so that an optical microscope is able to perform imaging free from collision even in a difficult geometric condition.SOLUTION: In order to incline each illuminating focus (16, 84) with respect to the optical axis (O) of an illuminating optical system (10), a scanner (33) directs an illuminating light beam (12) to a partial area away from the pupil center of the incident pupil (14) of the illuminating optical system (10). Also, in order to move the illuminating focus (16, 84) over an illuminating target area, the scanner changes the direction of incidence of the illuminating light beam (12) within the partial area. An observation objective lens (38) spatially separated from the illuminating optical system (10) is provided. The observation objective lens (38) is arranged so that its optical axis (O) is located substantially perpendicular to the illuminating target area and so that this axis forms an acute angle (α) with respect to the optical axis (O) of the illuminating optical system (10).
Abstract translation: 要解决的问题：为了改善扫描显微镜，使得光学显微镜即使在困难的几何条件下也能够进行没有碰撞的成像。 解决方案：为了相对于照明光学系统（10）的光轴（O
1 ）倾斜每个照明聚焦（16,84），扫描仪 （33）将照明光束（12）引导到远离照明光学系统（10）的入射光瞳（14）的光瞳中心的部分区域。 此外，为了将照明聚焦（16,84）移动到照明目标区域上，扫描器改变部分区域内的照明光束（12）的入射方向。 提供了与照明光学系统（10）在空间上分离的观察物镜（38）。 观察物镜38设置为使其光轴（O 3 ）基本上垂直于照明目标区域，并且使得该轴形成锐角（α ）相对于照明光学系统（10）的光轴（O 1 ）。 版权所有（C）2013，JPO＆INPIT -
公开(公告)号：JP2001324679A
公开(公告)日：2001-11-22
申请号：JP2001100297
申请日：2001-03-30
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFFMANN JUERGEN , STORZ RAFAEL , ULRICH HEINRICH , BEWERSDORF JOERG , BIRK HOLGER
Abstract: PROBLEM TO BE SOLVED: To form a low output power laser beam source which can be utilized especially as a light source for a confocal scanning type microscopic method. SOLUTION: In this device for coupling beams from at least two laser beam sources 1 and 2 related to the confocal scanning type microscopic method, the beams from the laser beam sources 1 and 2 at least have nearly the same wavelength. The device is provided with at least a beam coupling device 11 coupling light beams by a system hardly having loss.
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公开(公告)号：JP2001235684A
公开(公告)日：2001-08-31
申请号：JP2001020141
申请日：2001-01-29
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , ULRICH HEINRICH
Abstract: PROBLEM TO BE SOLVED: To provide the characteristic of a confocal scanning type microscope design in which a high signal output and a high ratio between a signal and a noise are realized with a simple means. SOLUTION: In a microscope design for a confocal scanning type microscope having a light source 1 to irradiate an object 6 which is an inspection object specially by using exciting light 2 and at least two detection channels 8 and 9 indicating formed detection light, at least two detection channels are optically superposed by superposing devices 11, 12, 13, 15, 17 and 18 with respect to the high signal output and the high ratio between the signal and the noise.
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公开(公告)号：JP2001142002A
公开(公告)日：2001-05-25
申请号：JP2000310662
申请日：2000-10-11
Applicant: LEICA MICROSYSTEMS
Inventor： KNEBEL WERNER , ULRICH HEINRICH
Abstract: PROBLEM TO BE SOLVED: To provide a general type confocal laser scanning microscope constituted so that a light source which is inexpensively acquired and operated can be used for the purpose of CLSM. SOLUTION: This confocal laser scanning microscope having at least one detector 4 to detect detecting light 3 coming from at least one laser beam source 1 for irradiating a sample 2 is provided with additional light source 5 and 8 which are not single mode (TEM00) laser beam sources in order to extend the use of the CLSM while using the light source which is inexpensively acquired and operated.
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公开(公告)号：JP2009139969A
公开(公告)日：2009-06-25
申请号：JP2009013039
申请日：2009-01-23
Inventor： ENGELHARDT JOHANN , BRADL JOACHIM , ULRICH HEINRICH
IPC: G01N21/64 , G02B21/06 , G01J3/36 , G02B5/04 , G02B5/32 , G02B21/00 , G02B21/18 , G02F1/11 , G02F1/33
CPC classification number: G02B21/0076 , G02B21/0024
Abstract: PROBLEM TO BE SOLVED: To design and develop an optical arrangement in a beam path of a light source suitable for fluorescence excitation, preferably in a beam path of a confocal laser scanning microscope such that injection of excitation light of various excitation wavelengths is possible without having to switch or make special adjustment to the optical elements used when switching the wavelength of the excitation light.
SOLUTION: The optical arrangement comprises at least one spectrally selective element (4) for injecting excitation light (3) of at least one light source (2) in the microscope and for separating and extracting the excitation light (3) scattered and reflected on an object (10) or for extracting the excitation light from light (13) coming from the object (10) via a detection beam path (12). The optical arrangement in the beam path of the light source suitable for fluorescence excitation, preferably in the beam path of the confocal laser scanning microscope is characterized in that excitation light (3, 9) of different wavelengths can be separated and extracted by the spectrally selective element (4) so that configuration can be changed with the simplest structure. Alternatively, the optical arrangement like this is characterized in that the spectrally selective element (4) can be adjusted to the excitation wavelength to be separated and extracted.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 要解决的问题：为了设计和开发适合于荧光激发的光源的光束路径中的光学布置，优选地在共聚焦激光扫描显微镜的光束路径中，使得各种激发波长的激发光的注入是 可以在切换激发光的波长时不必切换或对所使用的光学元件进行特殊调整。 解决方案：光学装置包括至少一个光谱选择性元件（4），用于在显微镜中注入至少一个光源（2）的激发光（3），并用于分离和提取散射的激发光（3） 在物体（10）上反射或者经由检测光束路径（12）从来自物体（10）的光（13）提取激发光。 适用于荧光激发的光源的光路中的光学布置优选在共聚焦激光扫描显微镜的光束路径中的特征在于可以通过光谱选择性分离和提取不同波长的激发光（3,9） 元件（4），从而可以以最简单的结构改变配置。 或者，这样的光学布置的特征在于，可以将光谱选择性元件（4）调整到激发波长以被分离和提取。 版权所有（C）2009，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2006235629A
公开(公告)日：2006-09-07
申请号：JP2006043887
申请日：2006-02-21
Inventor： STORZ RAFAEL , BIRK HOLGER , ULRICH HEINRICH , EUTENEUER PETER
CPC classification number: G02B21/0036
Abstract: PROBLEM TO BE SOLVED: To constitute a scanning microscope so that, above all, it can be adjusted very easily.
SOLUTION: The scanning microscope or a raster microscope has a system, provided with a scan head (2) having a scanner (1) for a light beam and a scanning barrel lens (3), where the scanning barrel lens (3) is coupled to the scanning head (2).
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题：为了构成扫描显微镜，首先它可以非常容易地调节。 解决方案：扫描显微镜或光栅显微镜具有系统，其具有扫描头（2），扫描头（2）具有用于光束的扫描仪（1）和扫描镜筒（3），其中扫描筒镜 ）耦合到扫描头（2）。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2006209111A
公开(公告)日：2006-08-10
申请号：JP2006008728
申请日：2006-01-17
Inventor： STORZ RAFAEL , ULRICH HEINRICH
CPC classification number: G02B21/248 , G02B21/26
Abstract: PROBLEM TO BE SOLVED: To provide a microscope with an eye towards achieving a particularly simple structure.
SOLUTION: An objective (1) and/or an objective changer and/or an objective turret is/are coupled to an adjustment device (3) for positioning a specimen stage (6) in such a way that the position of the objective (1) and/or the objective changer and/or the objective turret can be adjusted by using the adjustment device (3).
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题：为了使显微镜具有实现特别简单结构的目的。 解决方案：物镜（1）和/或物镜更换器和/或物镜转盘被耦合到调节装置（3），用于将样品台（6）定位成使得样品台（6）的位置 可以通过使用调节装置（3）来调节物镜（1）和/或物镜和/或物镜转塔。 版权所有（C）2006，JPO＆NCIPI
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8.发明专利Apparatus for determining light power level, microscope, and method for microscopy 审中-公开用于确定光功率级别，显微镜和显微镜方法的装置
公开(公告)号：JP2003075764A
公开(公告)日：2003-03-12
申请号：JP2002152540
申请日：2002-05-27
Inventor： ULRICH HEINRICH , BIRK HOLGER , HAY WILLIAM C , NISSLE HOLGER
CPC classification number: G02B27/108 , G02B21/00 , G02B27/144 , G11B7/00
Abstract: PROBLEM TO BE SOLVED: To provide an apparatus for determining a light power level by a sufficiently precise and reproducible method.
SOLUTION: The apparatus for determining the light power level of a light beam (7) has a beamsplitter (1) and a detector (11) associated with the beamsplitter (1). The apparatus is characterized in that the beamsplitter (1) splits measuring light (23) from the light beam and conveys it to the detector (11), and that the ratio between the light power level of the light beam (7) and the light power level of the measuring light (23) measured at the detector (11) is constant over time.
COPYRIGHT: (C)2003,JPOAbstract translation: 要解决的问题：提供一种通过足够精确和可再现的方法来确定光功率水平的装置。 解决方案：用于确定光束（7）的光功率电平的装置具有与分束器（1）相关联的分束器（1）和检测器（11）。 该装置的特征在于分束器（1）从光束分离测量光（23）并将其传送到检测器（11），并且光束（7）的光功率级与光 在检测器（11）处测量的测量光（23）的功率电平随时间变化是恒定的。
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公开(公告)号：JP2001147376A
公开(公告)日：2001-05-29
申请号：JP2000280593
申请日：2000-09-14
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , ULRICH HEINRICH , HAY WILIAM C
Abstract: PROBLEM TO BE SOLVED: To provide a method for executing absolute measurement of various objects with sufficient accuracy and correcting disturbances to a measurement condition in a laser scan microscope, especially, a confocal laser scan microscope. SOLUTION: At least one reference optical path 9 used for reference measurement is installed. Reference light can be coupled to the reference optical path 9 from an illumination optical path 4. A detection device 6 can detect the reference light qualitatively and (or) quantitatively.
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10.发明申请
公开(公告)号：WO0005613A3
公开(公告)日：2000-06-15
申请号：PCT/DE9902095
申请日：1999-07-06
Applicant: LEICA MICROSYSTEMS , ULRICH HEINRICH , BORLINGHAUS ROLF
Inventor： ULRICH HEINRICH , BORLINGHAUS ROLF
CPC classification number: G02B21/06
Abstract: The invention relates to an optical arrangement for transmitting short laser pulses in optical fibers (2), especially for injection into a laser microscope, preferably for use in two-photon laser microscopy. The inventive arrangement comprises a short-pulse laser light source (1) and at least one optical fiber (2). An optical device (3) for temporally modifying the laser pulses is provided between the laser light source (1) and the optical fiber (2). The optical arrangement is provided for compensating an unintentional fiber dispersion and non-linear effects resulting from high energy densities, mainly self-phase modulation. The invention is characterized in that the optical device (3) is configured as a section which is, for the most part, comprised of a transparent, dispersive medium and which is located in the beam path (4) in front of the optical fiber (2) which serves the time extension of the laser pulses (pulse spreading).
Abstract translation: 在光纤（2）发送短激光脉冲，特别是用于耦合到激光显微镜，优选用于双光子激光显微术使用，具有短脉冲激光光源的光学装置（1）和至少一个光学纤维（2）之间，其中所述 激光光源（1）和所述光纤（2）被设置用于改变激光脉冲的时间的光学装置（3），以补偿不希望的纤维分散性和非线性效应由于高的能量密度，主要是自相位调制，其特征在于光学装置（3） 作为光纤被执行（2）之前，从在光路（4）的透明，分散介质距离现有至少在很大程度上，时间拉伸中使用的激光脉冲（脉冲展宽）的。
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