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    지질 이중층 상에 말단 에폭시기를 갖는 고체 입자 및 그를 제조하는 방법
    92.
    发明公开
    지질 이중층 상에 말단 에폭시기를 갖는 고체 입자 및 그를 제조하는 방법 有权
    具有末端环氧基团的固体颗粒在脂质双层上的制备及其制备方法

    公开(公告)号：KR1020120055385A

    公开(公告)日：2012-05-31

    申请号：KR1020100117104

    申请日：2010-11-23

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 송재영 ,  최은진 ,  이창희 ,  정호섭 ,  김기성 ,  강도현

    IPC: C07D303/12 ,  G01N33/92 ,  C07C57/24

    Abstract: PURPOSE: A solid particle having end epoxy radical on lipid bilayer and a manufacturing method thereof are provided to uniformly fix molecules having amino radicals under mild condition. CONSTITUTION: A solid particle having end epoxy radical includes lipid bilayer coated with polyelectrolyte material on a surface. The lipid bilayer comprises a first lipid molecule and a second lipid molecule. The first lipid molecule is diacetylene having the first lipid molecule having epoxy radical in the end. The second lipid molecule is a different lipid molecule from the first lipid molecule. A solid particle before being coated with the polyelectrolyte material is negative charged material. A cationic polyelectrolyte material and electronegative polyelectrolyte material are coated by turns.

    Abstract translation: 目的：提供在脂质双层上具有末端环氧基的固体颗粒及其制备方法，以均匀地固定温和条件下具有氨基的分子。 构成：具有末端环氧基的固体颗粒包括在表面上用聚电解质材料涂覆的脂质双层。 脂质双层包含第一脂质分子和第二脂质分子。 第一脂质分子是具有最终具有环氧基的第一脂质分子的乙炔。 第二脂质分子是与第一脂质分子不同的脂质分子。 在用聚电解质材料涂覆之前的固体颗粒是负带电材料。 阳离子聚电解质材料和电负极聚电解质材料被轮转涂覆。

    돼지 유행성설사병바이러스 중화 항체의 단쇄 가변 분절을 세균체 막표면에 발현하게 하는 벡터 및 돼지 유행성설사병 바이러스 증식을 억제하는 대장균
    98.
    发明公开
    돼지 유행성설사병바이러스 중화 항체의 단쇄 가변 분절을 세균체 막표면에 발현하게 하는 벡터 및 돼지 유행성설사병 바이러스 증식을 억제하는 대장균 有权
    转移载体，以表达单链抗变态反应片段，用于阻止细菌外膜上的PORCINE流行性腹膜病毒和E.COLI阻止PORCINE Epidemic DiarRHEA病毒的传播

    公开(公告)号：KR1020090011215A

    公开(公告)日：2009-02-02

    申请号：KR1020070074583

    申请日：2007-07-25

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 현방훈 ,  표현미 ,  김인중 ,  조수동 ,  김성희 ,  송재영

    IPC: C12N15/64 ,  C12N15/13 ,  C12N15/09

    Abstract: A vector and Escherichia coli suppressing proliferation of PED virus are provided to neutralize specifically the porcine epidemic diarrhea virus by being transformed to a surface expression vector and to reveal short chain variable segments of a porcine epidemic diarrhea virus neutralizing antibody at a film surface of a bacterial body. A surface expression vector reveals short chain variable segments of porcine epidemic diarrhea virus neutralizing antibody consisting of a sequence 1 at a film surface of a bacterial body. The surface expression vector includes a base sequence consisting of a sequence 1 and coding the short chain variable cleavage site specifically neutralized to porcine epidemic diarrhea virus(PEDV), T7 RNA polymerase consisting of a base sequence of 21bp~40bp of a sequence 4 and revealing the short chain variable split gene at a film surface of a bacterial body, a base sequence consisting of A sequence 2 coding A signal peptide of IgA proteinase gene of a gonococcus and an autotransporter beta domain gene consisting of a sequence 3 of the IgA proteinase of a base sequence coding six histidines and a gonococcus inserted into a bacterial membrane.

    Abstract translation: 提供抑制PED病毒增殖的载体和大肠杆菌，通过转化成表达表达载体来特异性中和猪流行性腹泻病毒，并显示在细菌膜表面的猪流行性腹泻病毒中和抗体的短链可变区段 身体。 表面表达载体揭示由细菌体的膜表面上的序列1组成的猪流行性腹泻病毒中和抗体的短链可变区段。 表面表达载体包括由序列1组成的碱基序列，并编码特异性中和到猪流行性腹泻病毒（PEDV）的短链可变切割位点，由序列4的21bp〜40bp的碱基序列组成的T7RNA聚合酶，并显示 在细菌体的膜表面的短链可变分裂基因，由编码淋球菌的IgA蛋白酶基因的A序列2的A序列组成的碱基序列和由IgA蛋白酶的序列3组成的自身转运蛋白β结构域基因 编码六个组氨酸的碱基序列和插入到细菌膜中的球菌属。

    돼지 유행성설사병 바이러스를 중화하는 특이 단클론 항체단쇄가변분절 유전자 및 이를 발현한 재조합단백질
    99.
    发明公开
    돼지 유행성설사병 바이러스를 중화하는 특이 단클론 항체단쇄가변분절 유전자 및 이를 발현한 재조합단백질 有权
    SCFV基因及其单克隆抗体2C10的重组蛋白中和病毒性腹膜病毒

    公开(公告)号：KR1020090011205A

    公开(公告)日：2009-02-02

    申请号：KR1020070074569

    申请日：2007-07-25

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 현방훈 ,  표현미 ,  김인중 ,  조수동 ,  김성희 ,  송재영 ,  권준헌

    IPC: C12N15/13 ,  C12N15/10 ,  C12N15/09

    Abstract: A gene comprising monoclonal antibody short chain variable segments neutralizing specifically porcine epidemic diarrhea virus(PEDV) is provided to prevent and treat PED pig disease. A gene comprising short chain variable segments neutralizes specifically porcine epidemic diarrhea virus(PEDV) consisting of a base sequence of a sequence 1. The gene comprising the short chain variable segments includes a heavy chain variable(VH) part consisting of a base sequence of 25~330 bp of the sequence 1 and a chain variable(VL) part consisting of a base sequence of 436~759 bp of the sequence 1. A monoclonal antibody includes a heavy chain variable(VH) part consisting of a base sequence of 25~330 bp of the sequence 1 and a chain variable(VL) part consisting of a base sequence of 436~759 bp of the sequence 1.

    Abstract translation: 提供包含中和特异性猪流行性腹泻病毒（PEDV）的单克隆抗体短链可变区的基因，以预防和治疗PED猪病。 包含短链可变区的基因特异性中和由序列1的碱基序列组成的猪流行性腹泻病毒（PEDV）。包含短链可变区的基因包括由25个碱基序列组成的重链可变（VH）部分 序列1〜330bp和由序列1的436〜759bp的碱基序列构成的链可变（VL）部分。单克隆抗体包括由25〜 序列1的330bp和由序列1的436〜759bp的碱基序列组成的链变量（VL）部分。

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