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    Conjugados de glicanos y uso de los mismos
    94.
    发明专利
    Conjugados de glicanos y uso de los mismos 未知

    公开(公告)号：ES2820303T3

    公开(公告)日：2021-04-20

    申请号：ES15833684

    申请日：2015-08-21

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  LEE HSIN-YU

    IPC: A61K39/00 ,  A61K47/64 ,  C07K14/33 ,  C07K14/34

    Abstract: Una composición inmunogénica que comprende: (a) un conjugado de glicanos que comprende por lo menos un glicano con un conector y un portador, el por lo menos un glicano estando conjugado con el portador a través del conector; y (b) un adyuvante, en donde el por lo menos un glicano con el conector tiene una estructura química de fórmula (II): **(Ver fórmula)** en donde: R1 se selecciona del grupo que consiste de -F, -N3, -NO2, **(Ver fórmula)** y R2 es -CH3; o R1 es -OH, y R2 se selecciona del grupo que consiste de -CH2F, -CH2N3, -CH2OH y -C≡CH.

    Novel glycan conjugates and methods of use thereof
    95.
    发明专利
    Novel glycan conjugates and methods of use thereof 未知

    公开(公告)号：AU2021200283A1

    公开(公告)日：2021-03-18

    申请号：AU2021200283

    申请日：2021-01-18

    Applicant: ACADEMIA SINICA

    Inventor： WU CHUNG-YI ,  WONG CHI-HUEY

    IPC: G01N33/53

    Abstract: The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. DM2\6073646.1

    Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
    97.
    发明专利
    Compositions and methods relating to universal glycoforms for enhanced antibody efficacy 未知

    公开(公告)号：AU2021200644A1

    公开(公告)日：2021-03-04

    申请号：AU2021200644

    申请日：2021-02-02

    Applicant: ACADEMIA SINICA

    Inventor： WU CHUNG-YI ,  MA CHE ,  WONG CHI-HUEY

    IPC: C07K16/28

    Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a gly-coengineered Fc region, wherein said Fe region comprises an optimized N glycan having the structure of Sia2(a2 - 6)Gal2GlcNAc2Man 3GlcNAc2 . The glycoengineered Fe region binds FcyRIIA or FeyRIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fe region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcyR is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

    Cancer markers and methods of use thereof
    98.
    发明专利
    Cancer markers and methods of use thereof 未知

    公开(公告)号：AU2016209056B2

    公开(公告)日：2021-01-28

    申请号：AU2016209056

    申请日：2016-01-25

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  CHEUNG SARAH K C ,  CHUANG PO-KAI ,  HSU TSUI-LING

    IPC: G01N33/574 ,  A61K39/00 ,  A61P35/00

    Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.

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