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    92.
    发明专利
    未知

    公开(公告)号：AT286870T

    公开(公告)日：2005-01-15

    申请号：AT00904982

    申请日：2000-01-29

    Applicant: BASF AG

    Inventor： DITRICH KLAUS ,  BLOCK ULRICH

    IPC: C07B61/00 ,  C07C51/48 ,  C07C59/125 ,  C07C67/08 ,  C07C67/54 ,  C07C69/708

    Abstract: The present invention relates to a novel process for the preparation of esters of the general formula Ifrom compounds of the general formula II contained in aqueous solutionswhich comprisesa) extracting the compounds of the general formula II directly or after liberation from their salts in the presence of a C1-C8-alcohol and a water-immiscible solvent andb) then esterifying with the C1-C8-alcohol in the presence of a catalyst and of an entraining agent under the conditions of an azeotropic distillation,where the process steps (a) and (b) can be carried out separately in terms of time and space or else in a successive continuous or batchwise sequence and where the variables and substituents in the formulae I and II have the following meanings:R =F, Cl, -OH, -OC1-C10-alkyl,R =H, C1-C10-alkyl;R =C1-C8-alkyl,Q=-OH, -O K , where K is an alkali metal cation or alkaline earth metal cation,n=0, 1 or 2.

    93.
    发明专利
    未知

    公开(公告)号：AT260984T

    公开(公告)日：2004-03-15

    申请号：AT98109999

    申请日：1998-06-02

    Applicant: BASF AG

    Inventor： STUERMER RAINER ,  DITRICH KLAUS ,  SIEGEL WOLFGANG

    IPC: C12P13/00 ,  C07C229/48 ,  C07C233/63 ,  C07C235/12 ,  C07C235/14 ,  C07C321/06 ,  C12P13/04 ,  C12P41/00

    Abstract: Production of acylated amino acid esters comprises acylating an amino acid ester with a carboxylic acid ester, which carries a halo, N, O or S atom in the neighbourhood of the carbonyl group of the acid component, in the presence of an amidase, protease, esterase or lipase as catalyst. Also claimed are (1) the production of optically active amino acid esters by: (a) enantioselectively acylating a racemic amino acid ester with a carboxylic acid ester, which carries a halo, N, O or S atom in the neighbourhood of the carbonyl group of the acid component, in the presence of an amidase, protease, esterase or lipase as catalyst; (b) separating the mixture obtained into optically active amino acid ester and optically active N-acyl-amino acid ester; and optionally (c) converting the optically active N-acyl-amino acid ester into the opposite amino acid ester enantiomer by amide cleavage; and (2) optically active amino acid esters of formula (I) and optically active N-acyl-amino acid esters of formula (II ) in which the NH2 and COOCH3 (or amino and COOR groups) are cis or trans to one another: R = 1-10C alkyl; 1-4C alkoxy; OH; NH2; halo; or Ar; R = H or 1-10C alkyl; X = halo; OR ; SR ; or NR R ; R and R = H; 1-10C alkyl; or Ar; R = 1-10C alkyl or Ar; Ar = aryl optionally substituted by NH2, OH, 1-4C alkyl, 1-4C alkoxy or halo; i = 0-4; m = 0-2; n = 1-3.

    94.
    发明专利
    未知

    公开(公告)号：PT801683E

    公开(公告)日：2002-09-30

    申请号：PT96900601

    申请日：1996-01-20

    Applicant: BASF AG

    Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUBLING CHRISTOPH

    IPC: C12P13/02 ,  C12P41/00

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

    97.
    发明专利
    未知

    公开(公告)号：ES2145480T3

    公开(公告)日：2000-07-01

    申请号：ES96929327

    申请日：1996-08-26

    Applicant: BASF AG

    Inventor： WETTERICH FRANK ,  WAGNER OLIVER ,  EICKEN KARL ,  DITRICH KLAUS ,  AMMERMANN EBERHARD ,  LORENZ GISELA

    IPC: C07C269/04 ,  A01N47/12 ,  C07C269/06 ,  C07C271/22

    Abstract: PCT No. PCT/EP96/03755 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Aug. 26, 1996 PCT Pub. No. WO97/08138 PCT Pub. Date Mar. 6, 1997Carbamoylcarboxamides of the general formula I (R1=unsubstituted or substituted alkyl, alkenyl, alkynyl; R2=hydrogen, halogen, cyano, nitro, or unsubstituted or substituted alkyl, alkoxy, alkylthio, or an unsubstituted or substituted phenyl group which is bonded via oxygen or sulfur) and compositions comprising them, processes for their preparation, and the use of the compounds I and of the compositions.

    99.
    发明专利
    未知

    公开(公告)号：AT191451T

    公开(公告)日：2000-04-15

    申请号：AT96931783

    申请日：1996-09-09

    Applicant: BASF AG

    Inventor： DITRICH KLAUS ,  BALKENHOHL FRIEDHELM ,  LADNER WOLFGANG

    IPC: C12M1/40 ,  B01J23/04 ,  C07B53/00 ,  C07B61/00 ,  C07C69/708 ,  C07C209/62 ,  C07C211/27

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

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