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公开(公告)号：ZA9510953B
公开(公告)日：1997-06-23
申请号：ZA9510953
申请日：1995-12-22
Applicant: BASF AG
Inventor： ROSENBERG JOERG , MAIER WERNER , BREITENBACH JOERG
Abstract: PCT No. PCT/EP95/05119 Sec. 371 Date Jun. 20, 1997 Sec. 102(e) Date Jun. 20, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/19964 PCT Pub. Date Jul. 4, 1996The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.
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92.发明专利
公开(公告)号：CA2232356A1
公开(公告)日：1997-05-01
申请号：CA2232356
申请日：1996-10-23
Applicant: BASF AG
Inventor： ROSENBERG JOERG , SCHIESSL MICHAEL , ZETTLER HANS DIETER , HOFMANN JUERGEN , BREITENBACH JOERG , H RTL AXEL PAUL
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60 , A61K9/02 , A61K31/19 , A61K31/275 , A61K31/40 , A61K31/455
Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.
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公开(公告)号：HUT75161A
公开(公告)日：1997-04-28
申请号：HU9602878
申请日：1995-04-05
Applicant: BASF AG
Inventor： GRABOWSKI SVEN , ROSENBERG JOERG , SANNER AXEL
Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.
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公开(公告)号：CZ9603013A3
公开(公告)日：1997-03-12
申请号：CZ301396
申请日：1995-04-05
Applicant: BASF AG
Inventor： GRABOWSKI SVEN , ROSENBERG JOERG , SANNER AXEL
CPC classification number: A61K9/1652 , A61K9/1617 , A61K9/1694
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公开(公告)号：HU9603530D0
公开(公告)日：1997-02-28
申请号：HU9603530
申请日：1996-03-12
Applicant: BASF AG
Inventor： BREITENBACH JOERG , ROSENBERG JOERG
Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.
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Patent Agency Ranking
公开(公告)号：HU9602878D0
公开(公告)日：1996-12-30
申请号：HU9602878
申请日：1995-04-05
Applicant: BASF AG
Inventor： GRABOWSKI SVEN , ROSENBERG JOERG , SANNER AXEL
Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.
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公开(公告)号：NO964939D0
公开(公告)日：1996-11-20
申请号：NO964939
申请日：1996-11-20
Applicant: BASF AG
Inventor： ROSENBERG JOERG , BREITENBACH JORG
Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.
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公开(公告)号：CA2208722A1
公开(公告)日：1996-07-04
申请号：CA2208722
申请日：1995-12-22
Applicant: BASF AG
Inventor： ROSENBERG JOERG , MAIER WERNER , BREITENBACH JOERG
Abstract: The invention concerns a method of producing lenticular tablets by melt calendering, using form cylinders provided with ellipsoid-segment recesses. The proposed method produces tablets which are easy to trim and in which any misalignement between the top and bottom halves of the tablet is such that only a small residue needs to be ground off.
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公开(公告)号：ZA9403368B
公开(公告)日：1995-11-17
申请号：ZA9403368
申请日：1994-05-17
Applicant: BASF AG
Inventor： GRABOWSKI SVEN , MUELLER WINIFRIED , ROSENBERG JOERG , BINDER RUDOLF , SANNER AXEL
IPC: A61K47/32 , A61K9/14 , A61K31/37 , A61K31/41 , A61K31/425 , A61K31/433 , A61K47/38 , A61K
CPC classification number: A61K9/146 , A61K31/37 , A61K31/41 , A61K31/425 , A61K31/433
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公开(公告)号：NO954660D0
公开(公告)日：1995-11-17
申请号：NO954660
申请日：1995-11-17
Applicant: BASF AG
Inventor： GRABOWSKI SVEN , MUELLER WINFRIED , ROSENBERG JOERG , BINDER RUDOLF , SANNER AXEL
IPC: A61K47/32 , A61K9/14 , A61K31/37 , A61K31/41 , A61K31/425 , A61K31/433 , A61K47/30 , A61K47/38
Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.
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