公开(公告)号：EA020655B1

公开(公告)日：2014-12-30

申请号：EA201001497

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F13/00

Abstract: Предложеноустройство, содержащееа) стент; б) множествослоев, которыеобразуютмногослойноепокрытиенауказанномстенте; гдепоменьшеймереодинизуказанныхслоевсодержитбиорассасывающийсяполимери поменьшеймереодинизуказанныхслоевсодержитодинилиболеефармацевтическихагентов; гдепоменьшеймеречастьфармацевтическогоагентанаходитсяв кристаллическойилипоменьшеймерена 50% кристаллическойформе, гдеуказанноеустройствообеспечиваетпрофильэлюирования in vitro, вкоторомотпримерно 5 допримерно 25% фармацевтическогоагентаэлюируетсячерезоднисуткипослеконтактаустройствас элюирующейсредой.

公开(公告)号：BRPI0810370A2

公开(公告)日：2014-10-29

申请号：BRPI0810370

申请日：2008-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61L33/00 ,  A61F2/00 ,  A61F2/82

Abstract: Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

公开(公告)号：AU2011232760B2

公开(公告)日：2014-07-03

申请号：AU2011232760

申请日：2011-10-05

Applicant: MICELL TECHNOLOGIES INC

Inventor： TAYLOR CHARLES DOUGLAS ,  MCCLAIN JAMES B ,  SMOKE CLINT ,  COLE MICHAEL E ,  DEYOUNG JAMES

IPC: B05D3/00 ,  A61L2/00

Abstract: C:NRPobWCC\SXD\3914539_ .DOC-5/10/201I A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical 5 agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do I0 not substantially modify the morphology of said pharmaceutical agent.

公开(公告)号：SG192523A1

公开(公告)日：2013-08-30

申请号：SG2013054119

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.FIGURE 22

公开(公告)号：NZ588549A

公开(公告)日：2013-05-31

申请号：NZ58854909

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F13/00

Abstract: Patent No. 588549 Disclosed is a device comprising a. a stent; b. a plurality of layers that form a laminate coating on said stent; wherein at least two of said layers comprise a bioabsorbable polymer and at least one of said layers comprises an active agents; wherein at least a portion of the active agent is in crystalline form, and wherein said device provides an in vitro elution profile in which about 5% to about 25% of the active agent is eluted one day after the device is contacted with elution media, wherein said plurality of layers comprises a first polymer layer comprising the first bioabsorbable polymer and a second polymer layer comprising a second bioabsorbable polymer, wherein said at least one layer comprising said pharmaceutical agent is between said first polymer layer and said second polymer layer, wherein said second polymer layer has at least one contact point with at least one particle of said pharmaceutical agent in said pharmaceutical agent layer and said second polymer layer has at least one contact point with said first polymer layer.

公开(公告)号：SG183035A1

公开(公告)日：2012-08-30

申请号：SG2012052213

申请日：2008-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F2/82

Abstract: Provided herein is a coated coronary stent, comprising:, a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.FIGURE 14

公开(公告)号：MX2010011485A

公开(公告)日：2011-03-01

申请号：MX2010011485

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F13/00

Abstract: Aquí se provee un dispositivo que comprende: a. un stent; b. una pluralidad de capas sobre el marco del stent para formar el dispositivo; en donde por lo menos una de las capas comprende un polímero bioabsorbible y por lo menos una de las capas comprende uno o más agentes activos; en donde por lo menos parte del agente activo está en forma cristalina.

公开(公告)号：MX2009011248A

公开(公告)日：2010-01-15

申请号：MX2009011248

申请日：2008-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F2/00 ,  A61L33/00 ,  A61F2/82

Abstract: Se proporciona en la presente un stent coronario revestido que comprende: a. una estructura de stent; b. una pluralidad de capas depositadas en dicha estructura de stent para formar dicho stent coronario; en donde al menos una de dichas capas comprende un polímero bioabsorbible y al menos una de dichas capas comprende uno o más agentes activos; en donde al menos parte del agente activo está en forma cristalina.

公开(公告)号：CA2721832A1

公开(公告)日：2009-12-03

申请号：CA2721832

申请日：2009-04-17

Applicant: MICELL TECHNOLOGIES INC

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUGLAS

IPC: A61F13/00

Abstract: Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

公开(公告)号：AU2003299658A8

公开(公告)日：2004-08-30

申请号：AU2003299658

申请日：2003-12-08

Applicant: MICELL TECHNOLOGIES INC

Inventor： WAGNER MARK I ,  DEYOUNG JAMES P ,  MCCLAIN JAMES B ,  GROSS STEPHEN M

IPC: B05D1/18 ,  B08B7/00 ,  B81B3/00 ,  B81C1/00 ,  H01L21/00 ,  H01L21/306 ,  C03C23/00 ,  B08B5/00 ,  B08B3/00

Abstract: A method of displacing a supercritical fluid from a pressure vessel (e.g., in a microelectronic manufacturing process), with the steps of: providing an enclosed pressure vessel containing a first supercritical fluid (said supercritical fluid preferably comprising carbon dioxide); adding a second fluid (typically also a supercritical fluid) to said vessel, with said second fluid being added at a pressure greater than the pressure of the first supercritical fluid, and with said second fluid having a density less than that of the first supercritical fluid; forming an interface between the first supercritical fluid and the second fluid; and displacing at least a portion of the first supercritical fluid from the vessel with the pressure of the second, preferably fluid while maintaining the interface therebetween.