公开(公告)号：DE60201296D1

公开(公告)日：2004-10-28

申请号：DE60201296

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: C07D295/18 ,  A61K31/16 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：ES2187334B1

公开(公告)日：2004-09-16

申请号：ES200100105

申请日：2001-01-17

Applicant: SERVIER LAB

Inventor： MONGE VEGA ANTONIO ,  ALDANA MORAZA IGNACIO ,  CAIGNARD DANIEL-HENRI ,  LEVENS NIGEL ,  FELETOU MICHEL ,  DELLA ZUANA ODILE

IPC: A61P3/04 ,  C07C311/13 ,  C07C311/19 ,  C07D213/82 ,  C07D215/36 ,  C07D333/34 ,  C07C311/18 ,  A61K31/15 ,  A61K31/18 ,  C07C311/05

公开(公告)号：PL360090A1

公开(公告)日：2004-09-06

申请号：PL36009001

申请日：2001-10-11

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.

公开(公告)号：BR0114632A

公开(公告)日：2004-02-17

申请号：BR0114632

申请日：2001-10-11

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.

公开(公告)号：ZA200205599B

公开(公告)日：2003-12-01

申请号：ZA200205599

申请日：2002-07-12

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07D ,  A61K ,  A61P

Abstract: Compounds of formula (I): wherein: X represents an oxygen or a sulphur or CH 2 or R 1 and R 2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R 3 and R 4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.

公开(公告)号：SI1252150T1

公开(公告)日：2003-10-31

申请号：SI200130014

申请日：2001-02-01

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC-DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUMET GERALD ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/4353 ,  A61P3/06 ,  A61P3/10 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04

公开(公告)号：AU2003226860A1

公开(公告)日：2003-09-02

申请号：AU2003226860

申请日：2003-02-04

Applicant: SERVIER LAB

Inventor： DASSONVILLE ALEXANDRA ,  BRETECHE ANNE ,  DUFLOS MURIEL ,  BAUT GUILLAUME LE ,  PFEIFFER BRUNO ,  RENARD PIERRE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE

IPC: A61K31/122 ,  A61K31/222 ,  A61K31/4402 ,  A61P3/10 ,  C07C45/00 ,  C07C45/28 ,  C07C46/00 ,  C07C46/10 ,  C07C50/28 ,  C07C50/30 ,  C07D213/50

Abstract: Compound of formula (I): wherein: R 1 and R 2 , which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R 4 represents hydrogen or alkyl, R 5 represents hydrogen, alkyl, aryl or heteroaryl, R 3 represents aryl, heteroaryl, dicyclopropylmethyl or benzhydryl, or A-R 3 represents an optionally substituted naphthyl group, with the exclusion of 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-phenylethenyl)-1,4-benzoquinone, 2,5-dihydroxy-3-(4-methoxyphenyl)-6-(2-naphthyl)-1,4-benzoquinone and 2,5-dihydroxy-3-(2-naphthyl)-6-phenyl-1,4-benzoquinone. Medicinal products containing the same which are useful in the treatment of diseases associated with a deregulation of glycaemia.

公开(公告)号：AR030048A1

公开(公告)日：2003-08-13

申请号：ARP010100496

申请日：2001-02-02

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  BLANC DELMAS ELODIE ,  YOUS SAID ,  DEPREUX PATRICK ,  GUILLAUME D ,  DACQUET CATHERINE ,  LEVENS NIGEL ,  BOUTIN JEAN ALBERT ,  BENNEJEAN CAROLINE ,  RENARD PIERRE

IPC: A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61P1/00 ,  A61P1/04 ,  A61P1/14 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P13/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07B61/00 ,  C07D263/58 ,  C07D277/68 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  A61K31/4353

Abstract: Derivados heterocíclicos de formula 1 en la cual A, B, D, X, R1, R2, R3 y R4 son tal como se definen en la descripcion, sus enantiomeros y diastereoisomeros así como sus sales de adicion con un ácido o con una base farmacéuticamente aceptables; procedimiento para prepararlos y composiciones farmacéuticas que los contienen. Los derivados heterocíclicos de formula 1 son utiles para el tratamiento y/o la profilaxis de la hiperglucemias, de las dislipidemias y más particularmente en el tratamiento de las diabetes no insulinodependientes del tipo II, de la resistencia a la insulina, de la tolerancia a la glucosa, de los desordenes relacionados con el síndrome X, de las enfermedades arteriales coronarias y otras enfermedades cardiovasculares, de las enfermedades renales, de las retinopatías, de los desordenes relacionados con la activacion de las células endoteliales, de la psoriasis, del síndrome poliquístico de ovario, de la demencia, de la osteoporosis, de las enfermedades inflamatorias intestinales, de las distrofias miotonicas, de las pancreatitis, de la arterioesclerosis, del xantoma, pero también en el tratamiento o la prevencion de la diabetes de tipo I, de la obesidad, de la regulacion del apetito, de la anorexia, de la bulimia, de la anorexia nerviosa, así como de las patologías cancerosas y en especial de los cánceres hormonodependientes tales como el cáncer de pecho y el cáncer de colon, y como inhibidores de angiogénesis.

公开(公告)号：NO20031643L

公开(公告)日：2003-04-10

申请号：NO20031643

申请日：2003-04-10

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN-ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  A61D9/12

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.

公开(公告)号：NO20031643D0

公开(公告)日：2003-04-10

申请号：NO20031643

申请日：2003-04-10

Applicant: SERVIER LAB

Inventor： FAUCHERE JEAN-LUC ,  ORTUNO JEAN-CLAUDE ,  LEVENS NIGEL ,  CHAMORRO SUSANA ,  BOUTIN JEAN-ALBERT

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/55 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D

Abstract: A compound of formula (I): wherein: R1 and R2 represent hydrogen or a group as defined in the description, R3 represents hydrogen or alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, R4 represents a group of formula (II): wherein W and B are as defined in the description, R5 represents hydrogen or alkyl, A represents a group selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1-, V is as defined in the description.