公开(公告)号：EP1017425A1

公开(公告)日：2000-07-12

申请号：EP97938609.1

申请日：1997-08-26

Applicant: IMARx PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C.

IPC: A61K49/04 ,  A61B8/14

CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

公开(公告)号：EP0977597A4

公开(公告)日：2000-02-09

申请号：EP97940615

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

Abstract translation: 一种用于提供患者的内部区域的图像的方法已被开发出来。 该方法通过提供在成像期间组织和血液之间增强的对比度降低成像伪影。 该方法包括施用给患者组合的造影剂与肾血管扩张剂和执行区域的超声成像。 肾脏病，肾动脉狭窄，包括可以利用该方法进行诊断。

公开(公告)号：EP0693288B1

公开(公告)日：1999-10-13

申请号：EP95111117.8

申请日：1991-04-09

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C

IPC: A61K49/00

CPC classification number: G01R33/5601 ,  A61K49/105 ,  A61K49/1803 ,  A61K49/1806 ,  A61K49/1863

公开(公告)号：EP0935415A1

公开(公告)日：1999-08-18

申请号：EP97921460.0

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  McCREERY, Thomas

IPC: C12N15 ,  A61K9 ,  A61K41 ,  A61K45 ,  A61K47 ,  A61K48 ,  A61P3 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P21 ,  A61P31 ,  A61P35 ,  C12N5 ,  C12P21

CPC classification number: A61K48/00 ,  A61K9/1272 ,  A61K41/0028 ,  C12N15/87 ,  C12N15/88

Abstract: The present invention is directed, inter alia, to a method for delivering a compound into a cell comprising administering to the cell the compound to be delivered, an organic halide, and/or a carrier. Ultrasound may also be applied, if desired.

公开(公告)号：EP0580726B1

公开(公告)日：1999-06-02

申请号：EP92910021.2

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： Unger, Evan C.

IPC: C08F20/06 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  A61K49/04 ,  A61K49/00 ,  G01R33/28 ,  A61K51/00

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

公开(公告)号：EP0836420A1

公开(公告)日：1998-04-22

申请号：EP96920466.0

申请日：1996-05-24

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  YELLOWHAIR, David, W.

IPC: A61B18 ,  A61B8 ,  A61K41 ,  A61K49 ,  A61N7 ,  G06T1 ,  G01S15

CPC classification number: A61B8/12 ,  A61B8/0833 ,  A61B8/0883 ,  A61B8/445 ,  A61B8/4483 ,  A61B8/481 ,  A61K41/0028 ,  A61K49/223 ,  A61N7/00 ,  G01S15/8925 ,  G01S15/899

Abstract: Methods and apparatus (12-102) for performing diagnostic ultrasound simultaneously with the application of therapeutic ultrasonic waves are disclosed. The methods and apparatus (12-102) are particularly advantageous in performing ultrasonic imaging of a region of a patient while simultaneously applying therapeutic ultrasonic waves to the region for the purpose of rupturing vesicles administered to that region for purposes such as enhanced cavitation or the targeted release of a bioactive agent into the region. An operator is able to monitor the rupture of vesicles in real time.

公开(公告)号：EP0831932A1

公开(公告)日：1998-04-01

申请号：EP96921486.0

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： UNGER, Evan, C. ,  SHEN, Dekang ,  WU, Guanli

IPC: A61K47 ,  A61K45 ,  A61K49 ,  C08F220 ,  C08G65

CPC classification number: B82Y5/00 ,  A61K49/0002 ,  A61K49/223 ,  A61K49/227 ,  A61K49/228

Abstract: Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise a lipid, a protein or a polymer and a gas, in combination with a targeting ligand. The targeting ligand targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The contrast media can be used in conjunction with diagnostic imaging, such as ultrasound, as well as therapeutic applications, such as therapeutic ultrasound.

公开(公告)号：EP0797433A4

公开(公告)日：1997-12-03

申请号：EP95914685

申请日：1995-03-10

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： IMARX PHARMACEUTICAL CORP

IPC: A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/50 ,  A61K41/00 ,  A61K47/14 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  G01R33/28 ,  A61B5/055 ,  A61K31/16

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K9/5015 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1806 ,  A61K49/1815 ,  A61K49/1818 ,  A61K49/1821 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  G01R33/5601

Abstract: Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

Abstract translation: 提供可用作磁共振成像（MRI）造影剂的新型充气微球体。

公开(公告)号：EP0797433A1

公开(公告)日：1997-10-01

申请号：EP95914685.0

申请日：1995-03-10

Applicant: ImaRx Pharmaceutical Corp.

Inventor： ImaRx Pharmaceutical Corp.

IPC: A61K8 ,  A61K9 ,  A61K41 ,  A61K47 ,  A61K49 ,  A61Q19 ,  G01R33 ,  A61M5

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K9/5015 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1806 ,  A61K49/1815 ,  A61K49/1818 ,  A61K49/1821 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  G01R33/5601

Abstract: Novel gas filled microspheres useful as magnetic resonance imaging (MRI) contrast agents are provided.

Abstract translation: 提供可用作磁共振成像（MRI）造影剂的新型充气微球体。

公开(公告)号：DK0711127T4

公开(公告)日：2009-03-16

申请号：DK94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY ,  WU GUANLI ,  FRITZ THOMAS A ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.