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公开(公告)号：KR1020140046808A
公开(公告)日：2014-04-21
申请号：KR1020120112939
申请日：2012-10-11
Applicant: 한국화학연구원
IPC: A61K31/4375 , A61K31/40 , A61K31/015 , A61P9/10
CPC classification number: A61K31/135 , A61K31/40 , A61K31/4375 , Y10S514/824
Abstract: The present invention relates to a composition for preventing or treating heperproliferative vascular disorders including arteriosclerosis or angiostenosis. A compound disclosed in the present invention can be used as an effective therapeutic composition for treating diseases such as arteriosclerosis and angiostenosis by significantly inhibiting proliferation of vascular smooth muscle cells which plays a key role in a progression of hyperproliferative vascular disorders.
Abstract translation: 本发明涉及用于预防或治疗包括动脉硬化或血管狭窄的增生性血管病症的组合物。 本发明中公开的化合物可以通过显着抑制血管平滑肌细胞的增殖而用作治疗疾病如动脉硬化和血管狭窄的有效治疗组合物，所述血管平滑肌细胞在过度增殖性血管病症发展中起关键作用。
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公开(公告)号：KR1020110007978A
公开(公告)日：2011-01-25
申请号：KR1020100069018
申请日：2010-07-16
IPC: A61K31/35 , A61K31/352 , A23L1/30
CPC classification number: A61K31/352 , A23L33/10 , A61K31/35 , A23V2002/00 , A23V2200/306
Abstract: PURPOSE: A pharmaceutical composition containing Colforsin Daropate is provided to suppress bone absorption and to prevent or treat bond diseases. CONSTITUTION: A pharmaceutical composition for preventing or treating bone diseases contains 0.01-1 weight% of compound of chemical formula 1 or pharmaceutically acceptable salt thereof. The composition further contains pharmaceutically acceptable carrier. A health food for preventing or treating bone diseases contains the compound of chemical formula 1 or sitologically acceptable salt thereof.
Abstract translation: 目的：提供一种含有焦唑酸酯的药物组合物，以抑制骨吸收并预防或治疗粘连疾病。 构成：用于预防或治疗骨疾病的药物组合物含有0.01-1重量％的化学式1化合物或其药学上可接受的盐。 该组合物还含有药学上可接受的载体。 用于预防或治疗骨骼疾病的保健食品含有化学式1的化合物或其可以使用的盐。
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公开(公告)号：KR1020100009151A
公开(公告)日：2010-01-27
申请号：KR1020080069892
申请日：2008-07-18
IPC: A61K36/78 , A61K36/539 , A61P19/10
CPC classification number: A61K36/539 , A61K36/78 , A61K2300/00
Abstract: PURPOSE: A composition containing mixture extract of Saururus chinensis and Scutellaria baicalensis is provided to suppress osteoclast differentiation, enhance bone density and bone content, and prevent or treat osteoporosis. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. The weight ratio of the Saururus chinensis and Scutellaria baicalensis is 1:10-10:1. A food composition for preventing and relieving osteoporosis contains mixture extract of Saururus chinensis and Scutellaria baicalensis as an active ingredient. A method for producing the mixture extract comprises: a step of washing Saururus chinensis and Scutellaria baicalensis with water and drying; a step of extracting the Saururus chinensis and Scutellaria baicalensis with solvent; a step of cooling the extract at room temperature and filtering; a step of decompress-concentrating and freeze-drying; and a step of mixing the extract of Saururus chinensis and Scutellaria baicalensis.
Abstract translation: 目的：提供含有Saururus chinensis和黄芩的混合物提取物的组合物，以抑制破骨细胞分化，增强骨密度和骨含量，并预防或治疗骨质疏松症。 构成：用于预防或治疗骨质疏松症的药物组合物含有中华黄牛和黄芩的混合物提取物作为活性成分。 中华黄牛和黄芩的重量比为1:10-10:1。 用于预防和缓解骨质疏松症的食物组合物含有中华黄芪和黄芩的混合物提取物作为活性成分。 制备混合物提取物的方法包括：用水洗涤中华黄芩和黄芩的步骤; 用溶剂萃取中华黄龙和黄芩的一步; 在室温下冷却提取物并过滤的步骤; 减压浓缩和冷冻干燥步骤; 并将中国黄芪和黄芩提取物混合在一起。
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公开(公告)号：KR1020090039038A
公开(公告)日：2009-04-22
申请号：KR1020070104435
申请日：2007-10-17
Applicant: 한국화학연구원
IPC: C07D209/90 , A61K31/403 , A61P35/00
CPC classification number: C07D491/04
Abstract: A phenanthrene lactam derivative having the anticancer activity is provided to prevent and treat cancer and disease with excellent anticancer activity. A phenanthrene lactam derivative having chemical formula 1 is produced by reaction of the compound of chemical formula 2 and the compound of chemical formula 3 in a solution. R1, R2, R3, R4, R5, R6 and R7R is hydrogen, halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy or aryloxy. R4 and R5, R5 and R6, or R6 and R7 forms dioxol. R8 is the hydrogen or the C1-6 alkyl. The composite for preventing caner and pharmaceutical treatment comprises the phenanthrene lactam derivative of chemical formula 1 or pharmaceutically allowable salt.
Abstract translation: 提供具有抗癌活性的菲内酰胺衍生物，以预防和治疗具有优异抗癌活性的癌症和疾病。 具有化学式1的菲内酰胺衍生物通过化学式2的化合物和化学式3的化合物在溶液中的反应来制备。 R1，R2，R3，R4，R5，R6和R7R是氢，卤素，羟基，C1-6烷基，C1-6烷氧基或芳氧基。 R4和R5，R5和R6，或R6和R7形成二氧杂环戊烯。 R8是氢或C1-6烷基。 用于预防癌症和药物治疗的复合物包括化学式1的菲内酰胺衍生物或药学上可允许的盐。
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Patent Agency Ranking
公开(公告)号：KR1020080110393A
公开(公告)日：2008-12-18
申请号：KR1020070059084
申请日：2007-06-15
IPC: C07D401/14 , C07D417/14 , C07D413/14 , C07D513/04
CPC classification number: C07D413/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/14 , C07D417/12 , C07D513/04
Abstract: A pharmaceutical composition containing the triazole derivative having antifungal activity is provided to improve the antifungal activity against the various kinds of pathogens and reduce the toxicity as compared to the conventional antifungal agent, so that it is useful as the infection treatment agent of fungi. The pharmaceutical composition contains the triazole derivative having antifungal activity represented by the chemical formula(1) or the pharmaceutically acceptable salt, hydrate, solvate or isomer thereof, wherein n is 1 or 2; A indicates the direct coupling, C=O or CH2; and R is 5- to 10-membered monocyclic or bicyclic heteroaryl group containing 1 to 4 ring hetero atom independently selected from N, O and S.
Abstract translation: 提供含有具有抗真菌活性的三唑衍生物的药物组合物，以提高与各种病原体的抗真菌活性，并降低与常规抗真菌剂相比的毒性，因此可用作真菌感染处理剂。 药物组合物含有具有化学式（1）表示的抗真菌活性的三唑衍生物或其药学上可接受的盐，水合物，溶剂合物或异构体，其中n为1或2; A表示直接耦合，C = O或CH2; R为含有1至4个独立地选自N，O和S的环杂原子的5至10元单环或双环杂芳基。
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公开(公告)号：KR100844376B1
公开(公告)日：2008-07-07
申请号：KR1020070012901
申请日：2007-02-07
Applicant: 한국화학연구원
IPC: A61K31/357 , A61P19/10
CPC classification number: A61K31/357 , A23G9/32 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K36/185 , A23V2200/306 , A23V2250/21
Abstract: A composition comprising an extract of Myristica fragrans is provided to promote activity of osteoblast, thereby being usefully used to prevent or treat osteoporosis. A composition for preventing or treating osteoporosis comprises machilin A represented by a formula 1, macelignan represented by a formula 2, machilin F represented by a formula 3, nectandrin B represented by a formula 4, safrole represented by a formula 5, licarin A represented by a formula 6, licarin B represented by a formula 7, myristagenol A represented by a formula 8, meso-dihydroguaiaretic acid represented by a formula 9, a mixture thereof or an extract of Myristica fragrans comprising the compounds of the formulae(1) to (9) as effective ingredients, wherein the extract is prepared by using a solvent selected from the group consisting of C1-4 alcohol and an aqueous solution thereof, dichloromethane, ethyl acetate and a mixture thereof.
Abstract translation: 提供包含肉豆蔻提取物的组合物以促进成骨细胞的活性，从而有用地用于预防或治疗骨质疏松症。 用于预防或治疗骨质疏松症的组合物包括由式1表示的机械A，由式2表示的肉豆蔻衣木脂素，由式3表示的机械纤维F，由式4表示的nectandrin B，由式5表示的黄樟素， 式6，由式7表示的赖氨酸B，由式8表示的肉豆蔻酰胺A，由式9表示的内消旋 - 二氢愈创木酸，其混合物或肉豆蔻提取物，其包含式（1）至（ 9）作为有效成分，其中所述提取物通过使用选自C 1-4醇及其水溶液，二氯甲烷，乙酸乙酯及其混合物的溶剂制备。
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108.发明授权삼백초 추출물 또는 이로부터 분리된 활성 화합물을포함하는 골다공증 예방 또는 치료용 조성물 有权用于预防或治疗包含SAURURUS CHINENSIS或活性化合物提取物的OSTEOPOSOSIS的组合物，其分离
公开(公告)号：KR100833654B1
公开(公告)日：2008-05-29
申请号：KR1020070013661
申请日：2007-02-09
IPC: A61K36/78 , A61P19/10 , A61K31/341
CPC classification number: A61K36/78
Abstract: A composition comprising the extract of Saururus chinensis or active compounds isolated therefrom is provided to inhibit growth of osteoclast, so that the composition is useful for preventing or treating osteoporosis. A composition for preventing or treating osteoporosis comprises 0.01-30 wt.% of the extract of Saururus chinensis, which is prepared by extracting Saururus chinensis with C1-4 alcohol and its solution, dichloromethane, ethylacetate or a mixture thereof, or active compounds isolated from the Saururus chinensis extract including (-)-saucerneol represented by the formula(1) and sauristolactam represented by the formula(2), and is a pharmaceutical or health food composition having a formulation of beverage.
Abstract translation: 提供了包含中华黄牛提取物或从其分离的活性化合物的组合物以抑制破骨细胞的生长，使得该组合物可用于预防或治疗骨质疏松症。 用于预防或治疗骨质疏松症的组合物包括通过用C 1-4醇提取中华黄芪和其溶液，二氯甲烷，乙酸乙酯或其混合物或从其中分离的活性化合物制备的中华黄瓜提取物的0.01-30重量％ 含有由式（1）表示的（ - ） - 三氯蔗糖和由式（2）表示的沙拉耳内酰胺，是具有饮料配方的药物或保健食品组合物。
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109.发明授权ｐ53 종양 억제단백질과 형광단백질의 융합단백질을발현하는 형질전환 세포주 및 이를 이용한 ｐ53 종양억제단백질의 활성과 관련된 물질의 검색방법 有权改变表达p53肿瘤抑制蛋白的融合蛋白和荧光蛋白的方法和用于筛选与使用其的p53肿瘤抑制蛋白的活性相关的物质的方法
公开(公告)号：KR100791859B1
公开(公告)日：2008-01-07
申请号：KR1020050105417
申请日：2005-11-04
Applicant: 한국화학연구원
Abstract: 본 발명은 p53 종양 억제단백질(tumor suppressor)과 제1 형광단백질의 융합단백질 및 제2 형광단백질을 발현하는 형질전환 세포주, 및 이를 이용하여 p53 종양 억제단백질의 활성에 관여하는 물질을 검색하는 방법에 관한 것으로, 구체적으로 5'에서 3' 방향으로 143번째 아미노산인 발린이 알라닌으로 치환된 비활성 p53 종양 억제단백질 돌연변이 유전자; 상기 유전자에 융합된 제1 형광단백질 유전자; IRES(internal ribosome entry site) 리보솜 결합 염기서열; 및 제2 형광단백질 유전자를 포함하고, 이들의 발현이 하나의 프로모터에 의해 조절되는 재조합 발현벡터; 상기 발현벡터가 안정적으로 도입된 형질전환 세포주; 및 상기 형질전환 세포주를 이용하여 p53 종양 억제단백질의 활성을 증가시키거나 억제하는 물질을 검색하는 방법에 관한 것이다. 본 발명에 따른 재조합 발현벡터 및 형질전환 세포주는 p53 종양 억제단백질의 활성과 관련된 물질을 검색하기 위한 바이오센서로서 항암제, 항암치료 보조제 및 퇴행성 질환 관련 치료제를 스크리닝하는데 유용하게 사용될 수 있다.
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公开(公告)号：KR100738230B1
公开(公告)日：2007-07-12
申请号：KR1020030043425
申请日：2003-06-30
IPC: A61K31/15
Abstract: 본 발명은 활성 성분으로서 메톡시아크릴레이트계 화합물을 포함하는, 골다공증 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 조성물은 세포독성을 나타내지 않으면서 파골세포의 생성 및 골 흡수를 강력하게 억제하여 골다공증의 예방 또는 치료에 보다 간편하게 효율적으로 사용될 수 있다.
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