公开(公告)号：DE19933861A1

公开(公告)日：2001-01-25

申请号：DE19933861

申请日：1999-07-23

Applicant: BASF AG

Inventor： PFEIFFER THOMAS

IPC: C07D277/20 ,  C07D277/56 ,  C07K5/065

Abstract: 2-Aminomethyl-4-cyanothiazole (I) and its salts are new. 2-Aminomethyl-4-cyanothiazoleof formula (I) and its salts are new. n = 0 or 1; and X = Cl, Br, SO3CF3, HSO4 or 1/2 SO4. Independent claims are included for: (1) the preparation of (I); (2) methods for preparing thiazolecarboxylate ester or amide intermediates of formula (VI) or (VII); and (3) new N-protected derivatives of (I) having formula (X). R3 = benzyloxycarbonyl, 9-fluorenylmethoxycarbonyl, trifluoromethylacetyl, acetyl or benzoyl. R1 = 1-4C alkyl.

公开(公告)号：DE59702414D1

公开(公告)日：2000-11-02

申请号：DE59702414

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083

Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：CA2347757A1

公开(公告)日：2000-04-27

申请号：CA2347757

申请日：1999-10-13

Applicant: BASF AG

Inventor： MUNSCHAUER RAINER ,  VIERGUTZ WOLFGANG ,  BUSCHMANN ERNST ,  STEINER GERD ,  BISCHOF NORBERT ,  PFEIFFER THOMAS ,  KREI GEORG ARNOLD ,  HENNINGSEN MICHAEL

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3-azabicycl o- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds are characterized in that a bisallyl ammonium salt of formula (II), in which R has the above- mentioned meanings and X- represents an anion, is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+) - exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystallized out of an alcohol/water mixture.

公开(公告)号：HUT78040A

公开(公告)日：1999-06-28

申请号：HU9603474

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：NO990667A

公开(公告)日：1999-04-12

申请号：NO990667

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  A61K38/05

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D207/22 ,  C07D211/78 ,  Y02P20/55

公开(公告)号：NO990667D0

公开(公告)日：1999-02-12

申请号：NO990667

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  C07K

Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：ZA976637B

公开(公告)日：1999-01-25

申请号：ZA976637

申请日：1997-07-25

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C07D ,  C07B

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：DK0668869T3

公开(公告)日：1998-10-07

申请号：DK92913125

申请日：1992-06-23

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  HOEFFKEN HANS WOLFGANG ,  BOEHM HANS-JOACHIM ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  C07K1/113 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/078 ,  A61K37/02

Abstract: PCT No. PCT/EP92/01411 Sec. 371 Date Dec. 28, 1993 Sec. 102(e) Date Dec. 28, 1993 PCT Filed Jun. 23, 1992 PCT Pub. No. WO93/01208 PCT Pub. Date Jan. 21, 1993.2-Substituted 3-(4-amidinophenyl)propionic acid derivatives of the formula in which A, Ar and B have the meanings stated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.

公开(公告)号：AU3694997A

公开(公告)日：1998-02-20

申请号：AU3694997

申请日：1997-07-14

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：BR9509970A

公开(公告)日：1997-11-25

申请号：BR9509970

申请日：1995-11-25

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HEMULT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61P7/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087