公开(公告)号：WO1997009074A2

公开(公告)日：1997-03-13

申请号：PCT/US1996014258

申请日：1996-09-05

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PACKARD, Warren, J.

IPC: A61M01/28

CPC classification number: A61M1/28 ,  A61M1/166 ,  A61M1/281 ,  A61M5/1483 ,  A61M2205/123

Abstract: A variable pressure drive peritoneal dialysis system (10) has a pneumatic pressure system (16) for purging and controlling a flow of dialysate through a disposable dialysate cassette (23) of a disposable dialysate delivery set (21). The pneumatic pressure system (16) has a variable-opening flow proportional valve for supplying air at selected profiled pressure or vacuum to a pneumatic interface (18). The disposable dialysate cassette (23) has a diaphragm pump (P1, P2) actuable by the profiled air pressure or vacuum to move dialysate to and from a patient (28) via the disposable dialysate delivery set (21) at a desired profiled dialysate pressure.

Abstract translation: 可变压力驱动腹膜透析系统（10）具有气动压力系统（16），用于通过一次性透析液输送装置（21）的一次性透析盒（23）清洗和控制透析液的流动。 气动压力系统（16）具有可变开度的流量比例阀，用于将选定的成型压力或真空的空气供给气动接口（18）。 一次性透析液盒（23）具有隔膜泵（P1，P2），该隔膜泵可通过成型空气压力或真空致动，以透过一次性透析液输送组件（21）以期望的成型透析液压力将透析液移动到患者（28） 。

公开(公告)号：WO1996039072A1

公开(公告)日：1996-12-12

申请号：PCT/US1996009066

申请日：1996-06-05

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  EVANS, David ,  SWENDSON, David

IPC: A47L09/26

CPC classification number: A47L9/26 ,  F16L3/13 ,  F16L3/237

Abstract: An elongate electrical cable (18) and cable retaining clip (24), particularly adapted for use with medical devices, provides for the cable to be doubled on itself or coiled and to be clipped to itself for storage. When so stored, the cable is protected both from damage and from contamination of a connector (22) portion of the cable, both of which can adversely affect functionality of thecable (and medical device) with possible adverse patient safety considerations. The cable retaining clip provides for manual clipping of the cable to itself, and for release of the cable from its doubled or coiled storage position in response to a manual tug on the cable. Thus, the cable and medical device are ready for immediate use when necessary, and the cable is protected from damage and contamination.

Abstract translation: 特别适合于与医疗装置一起使用的细长电缆（18）和电缆固定夹（24）提供电缆在其自身上被加倍或卷绕并被夹紧到自身进行存储。 当这样存储时，电缆被保护不受电缆的连接器（22）部分的损坏和污染，这两者可能对可能的不利的患者安全考虑对电话（和医疗设备）的功能产生不利影响。 电缆固定夹可用于手动将电缆固定到自身上，并根据电缆上的手动拖船将电缆从其双重或卷绕的存放位置释放出来。 因此，必要时，电缆和医疗设备可以立即使用，并且保护电缆免受损坏和污染。

公开(公告)号：WO1996036296A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006826

申请日：1996-05-13

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PAULEY, Robin, G. ,  McLARTY, Donna, L. ,  KHARE, Atul, R. ,  STERNBERG, Shmuel ,  BOGGS, Daniel, R. ,  NEUENFELDT, Steven ,  JONES, Mark ,  BRAUKER, James, H. ,  MARTINSON, Laura, A.

IPC: A61F02/02

CPC classification number: A61K9/0024 ,  A61F2/022 ,  A61L27/38

Abstract: A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).

Abstract translation: 可渗透结构（16）形成容纳活细胞（14）的腔室（12）。 该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。 结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。 第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。 第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。 第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由 细胞浸润到第一（18）和第二（20）区域之间的不连续空间。 第三个就地区域（22）也可以具有提供免疫隔离效果的确认。 此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

公开(公告)号：WO1996034087A1

公开(公告)日：1996-10-31

申请号：PCT/BE1996000045

申请日：1996-04-22

Applicant: BAXTER INTERNATIONAL INC. ,  KERSTEN, Jean ,  BADER, Augustinus

Inventor： BAXTER INTERNATIONAL INC.

IPC: C12M03/06

CPC classification number: C12M29/04 ,  C12M23/24 ,  C12M23/34

Abstract: The invention concerns a bioreactor for the cell-treatment of fluids. The bioreactor comprises a component defining a chamber in which are disposed fluid-treatment cells, a liquid-permeable membrane which separates the chamber from a first channel in which the fluid to be treated flows, and a gas-permeable membrane separating the chamber from a second channel in which an oxygenous gas flows. The chamber comprises two cell layers separated by a permeable layer.

Abstract translation: 本发明涉及用于细胞处理流体的生物反应器。 生物反应器包括限定腔室的部件，其中设置有流体处理单元，将腔室与待处理流体流过的第一通道分离的液体渗透膜，以及将腔室与气体分离器的气体透过膜 第二通道，其中有氧气体流动。 该室包括由可渗透层隔开的两个细胞层。

公开(公告)号：WO1996025967A1

公开(公告)日：1996-08-29

申请号：PCT/US1996002237

申请日：1996-02-20

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  IMADA, Akio ,  TAKEDA, Tatsumichi

IPC: A61M25/00

CPC classification number: A61M25/0017 ,  Y10S128/912 ,  Y10S604/905

Abstract: A ring element (10) attaches to a length of tubing (12) to prevent contamination at a site (24) through which a portion of the length of tubing (12) extends. A resilient material having a first end (14) and a second end (16) is provided capable of mating to form a hollow, cylindrical shell (10). An electrically conductive material is provided on a surface of the resilient material. In a preferred embodiment, the conductive material includes silver. The ring element (10) may be placed on a tube (12) to prevent contamination at a site (24) through which a tube (12) is secured. The ring element (10) is connected to the tube (12) at the site (24) of injection of the tube (12) wherein the ring element (10) is capable of removal without removal of the tube (12) from the site (24). The ring element (10) is particularly adaptable for a transfer set connectable to a peritoneal cavity and insertable at a site (24) for, for example, peritoneal dialysis.

Abstract translation: 环形元件（10）连接到一段管（12），以防止管道（12）的一部分延伸穿过的位置（24）处的污染。 提供具有第一端（14）和第二端（16）的弹性材料，其能够配合以形成中空的圆柱形壳（10）。 导电材料设置在弹性材料的表面上。 在优选实施例中，导电材料包括银。 环元件（10）可以放置在管（12）上以防止在管（12）被固定的位置处的污染。 环形元件（10）在注射管（12）的位置（24）处连接到管（12），其中环元件（10）能够从该位置移除而不从管（12）移除 （24）。 环形元件（10）特别适用于可连接到腹腔的转移组件，并可插入到例如腹膜透析的部位（24）处。

公开(公告)号：WO1996025279A1

公开(公告)日：1996-08-22

申请号：PCT/US1996001816

申请日：1996-02-09

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PLAMTHOTTAM, Sebastian, S.

IPC: B29C41/00

CPC classification number: B29C41/003 ,  B29C41/14 ,  B29C41/22 ,  B29K2033/04 ,  B29K2105/0064

Abstract: The present invention involves a process of making a powder-free rubber article using a multiple dip process. The process comprises the steps of: a) dipping a former of the desired shape of the article into a composition consisting essentially of an aqueous acrylic ester latex and water soluble salts capable of coagulating a rubber latex; b) dipping the former in step (a) into a rubber latex to produce a second layer; c) leaching the second layer in water; d) curing the first and second layers; and e) stripping the resultant article from the former. The acrylic ester latex is a water insoluble polymer emulsion in water. The polymer is composed predominantly of acrylic ester groups which make up at least 50 % by weight of the polymer.

Abstract translation: 本发明涉及使用多次浸渍法制造无粉末橡胶制品的方法。 该方法包括以下步骤：a）将所述制品所需形状的前者浸入基本上由含水丙烯酸酯胶乳和能够凝固橡胶胶乳的水溶性盐组成的组合物中; b）将步骤（a）中的前者浸入橡胶胶乳中以产生第二层; c）将第二层浸入水中; d）固化第一层和第二层; 和e）从前者剥离所得物品。 丙烯酸酯胶乳是水中不溶于水的聚合物乳液。 聚合物主要由构成聚合物的至少50重量％的丙烯酸酯基组成。

公开(公告)号：WO1996023643A1

公开(公告)日：1996-08-08

申请号：PCT/US1996001388

申请日：1996-01-26

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PLAMTHOTTAM, Sebastian, S.

IPC: B29C41/14

CPC classification number: B29C41/22 ,  A61B42/00 ,  B29C41/14 ,  B29K2021/00 ,  B29K2075/00 ,  B29K2105/0064 ,  B29L2031/4864 ,  B32B25/08

Abstract: The present invention relates to a multiple-dip process for producing a powder-free glove having a polyurethane coating. The method of this invention involves dipping a former into a powder-free aqueous dispersion or emulsion of a polyurethane polymer or copolymer to form a first layer; dipping the first layer while still on the former into a powder-free coagulant; dipping the first layer into a latex compound to produce a second layer; leaching the second layer in water; curing the first and second layers; and stripping the resulting glove from the former. Gloves produced according to this process can be made in a continuous fashion without interruption and are more economical than conventional processes used to make powder free gloves. The method of this invention does not include a halogenation step but rather employs environmentally friendly materials which do not pose toxicity of environmental issues.

Abstract translation: 本发明涉及用于生产具有聚氨酯涂层的无粉手套的多浸渍方法。 本发明的方法包括将前者浸入聚氨酯聚合物或共聚物的无粉末水性分散体或乳液中以形成第一层; 将第一层浸在前者的同时浸入无粉凝结剂中; 将第一层浸入胶乳化合物中以产生第二层; 将第二层浸入水中; 固化第一层和第二层; 并从前者剥离所得到的手套。 根据该方法生产的手套可以连续制造而不中断，并且比用于制造无粉末手套的常规方法更经济。 本发明的方法不包括卤化步骤，而是使用不会引起环境问题的毒性的环境友好的材料。

公开(公告)号：WO1996020637A1

公开(公告)日：1996-07-11

申请号：PCT/US1995015063

申请日：1995-11-16

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DUDAR, Thomas, E. ,  GRAHAM, Peter

IPC: A61B05/00

CPC classification number: A61M25/0643 ,  A61B5/15003 ,  A61B5/150656 ,  A61B5/150732 ,  A61B5/154 ,  A61M5/3271 ,  A61M25/0631

Abstract: This invention is a protective shield (18) for a blood sampling unit that is movably engaged to an adapter (10) having a needle (12) attached. The shield attaches to a tube holder when the needle is covered by the shield. Longitudinal grooves (56) on the adapter (52) guide the shield between a first position, covering the needle, and a second position, exposing the needle. The shield can be locked in either the first position or the second position. The blood sampling unit is safely disassembled or re-assembled when the needle is covered by the shield. In an embodiment of the invention, a tip protector (42), removably attached to the adapter, extends through the length of the tube holder (44) to prevent needlesticks. The blood sampling unit and the tube holder can be assembled and disassembled when the tip protector is attached to the adapter, covering the needle. The tip protector is removed during a clinical procedure and then replaced after the clinical procedure is finished.

Abstract translation: 本发明是一种用于采血单元的保护罩（18），其可移动地接合到具有附接的针（12）的适配器（10）。 当针被护罩覆盖时，护罩连接到管座。 适配器（52）上的纵向槽（56）引导屏蔽在覆盖针的第一位置和第二位置之间，使针露出。 屏蔽可以锁定在第一位置或第二位置。 当针被护罩覆盖时，采血单元可以安全地拆卸或重新组装。 在本发明的一个实施例中，可移除地附接到适配器的尖端保护器（42）延伸穿过管保持器（44）的长度以防止针刺。 当尖端保护器附接到适配器上时，采血单元和管座可以组装和拆卸，覆盖针头。 在临床过程中将尖端保护器移除，然后在临床手术完成后更换。

公开(公告)号：WO1996011033A1

公开(公告)日：1996-04-18

申请号：PCT/US1995012121

申请日：1995-09-22

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  LO, Ying-Cheng ,  ODAK, Sanjay, V. ,  CASTELLANOS, Rafael, A.

IPC: A61M39/28

CPC classification number: F16L11/121 ,  A61M39/08 ,  A61M39/28

Abstract: A tubing (10) having members (12, 14) located on the inside surface (16) of a tubing. The flow through the tubing (10) is easily and completely occluded when the tubing is clamped, due to the members (12, 14) filling channels (18, 20) around the clamped site. Reduced clamping pressure is required to fully occlude the flow through the tubing (10). The tubing (10) undergoes less deformation upon clamping and returns to its pre-clamped form easily upon recovery.

Abstract translation: 具有位于管道的内表面（16）上的构件（12,14）的管道（10）。 由于构件（12,14）填充夹紧位置周围的通道（18,20），当管道被夹紧时，通过管道（10）的流动容易且完全闭塞。 需要降低夹紧压力以完全堵塞通过管道（10）的流动。 管道（10）在夹紧时经历较少的变形，并且在恢复时容易恢复到预夹紧形式。

公开(公告)号：WO1996010966A1

公开(公告)日：1996-04-18

申请号：PCT/US1995013070

申请日：1995-10-04

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  BRAUKER, James, H. ,  MARTINSON, Laura, A. ,  STERNBERG, Shmuel ,  BELLAMY, David

IPC: A61F02/00

CPC classification number: B01D69/02 ,  A61F2/00 ,  A61F2/0077 ,  A61F2/062 ,  A61F2/30767 ,  A61F2002/30911 ,  A61L27/18 ,  A61L27/50 ,  B01D67/003 ,  B01D67/0034 ,  B01D69/12 ,  B01D71/64 ,  B01D2325/08 ,  B01D2325/24 ,  C08L79/08

Abstract: Polymer membrane structures are microfabricated from polyimide film by lithography or etching. The microfabricated structures have systematically varied dimensions and geometries conducive to implanting in host tissue and the promotion, when implanted, of new vascular structures.

Abstract translation: 聚合物膜结构通过光刻或蚀刻由聚酰亚胺膜微制成。 微制造结构具有系统地变化的尺寸和几何形状，有助于植入宿主组织，并且在植入时促进新的血管结构。