PORTABLE RAMAN DIAGNOSTIC SYSTEM
    101.
    发明申请
    PORTABLE RAMAN DIAGNOSTIC SYSTEM 审中-公开
    便携式拉曼诊断系统

    公开(公告)号:WO2012019102A3

    公开(公告)日:2012-10-18

    申请号:PCT/US2011046750

    申请日:2011-08-05

    Abstract: The present invention relates to an integrated approach to measuring biological samples utilizing a process of eliminating the uninformative or spurious spectral regions which simultaneously removes the necessity for a full spectrograph-CCD system. This approach enables the use of a portable Raman diagnostic system, having significantly reduced size and weight while retaining the required sensitivity. The selection of only a limited number of spectral bands allows the construction of a miniaturized Raman instrument by replacing the spectrograph-CCD combination with an array of optical bandpass filters and light detector(s). One of the embodiments of such a design can incorporate a single photodiode as a light detector. A preferred embodiment of the present invention uses wavelength interval selection based on non-linear representation, such as support vector regression. The wavelength selection protocol is based on the minimization of cross-validation error in the training data. tral information. To acquire the full spectrum necessary for the analysis, a dispersive spectrograph and a CCD detector is typically employed.

    Abstract translation: 本发明涉及利用消除不信息或杂散光谱区域的过程来测量生物样品的综合方法,其同时消除了对全光谱仪-CDC系统的必要性。 这种方法使得能够使用便携式拉曼诊断系统,其具有显着减小的尺寸和重量,同时保持所需的灵敏度。 仅选择有限数量的光谱带允许通过用光学带通滤光器和光检测器阵列替换光谱仪-CDC组合来构建小型化的拉曼仪器。 这种设计的一个实施例可以结合单个光电二极管作为光检测器。 本发明的优选实施例使用基于非线性表示的波长间隔选择,例如支持向量回归。 波长选择协议基于训练数据中交叉验证错误的最小化。 tral信息。 为了获得分析所需的全部光谱,通常采用色散光谱仪和CCD检测器。

    HYPERSPECTRAL IMAGING SPECTROMETER FOR EARLY DETECTION OF SKIN CANCER
    103.
    发明申请
    HYPERSPECTRAL IMAGING SPECTROMETER FOR EARLY DETECTION OF SKIN CANCER 审中-公开
    用于早期检测皮肤癌的超检查成像光谱仪

    公开(公告)号:WO2008103918A1

    公开(公告)日:2008-08-28

    申请号:PCT/US2008/054743

    申请日:2008-02-22

    Abstract: An hyperspectral imaging system that may acquire high resolution spectral and image data in one step, avoiding image registration or image distortion problems, or the need for moving components. The invention employs an optical system that remaps light from normally contiguous elements of an object onto a planar detector in a way that provides interstitial space on the detector between the light from each object element. A dispersion element then generates a spectrum extending into the interstitial space so that the detector simultaneously captures imaging and spectral information. Eliminating the need for moving parts allows perfectly registered and skew-less image and spectral analysis of the skin and allows the practical construction of a rugged handheld device.

    Abstract translation: 可以在一个步骤中获得高分辨率光谱和图像数据的高光谱成像系统,避免图像配准或图像失真问题,或需要移动组件。 本发明采用一种光学系统,其将来自物体的正常连续元件的光重新映射到平面检测器上,其方法是在来自每个物体元件的光之间在检测器上提供间隙空间。 然后,色散元件产生延伸到间隙空间中的光谱,使得检测器同时捕获成像和光谱信息。 消除对移动部件的需要允许完美登记和无偏差的皮肤图像和光谱分析,并允许坚固的手持设备的实际构造。

    DOME GAS SENSOR
    104.
    发明申请
    DOME GAS SENSOR 审中-公开
    气球传感器

    公开(公告)号:WO2007091043A1

    公开(公告)日:2007-08-16

    申请号:PCT/GB2007/000401

    申请日:2007-02-06

    Abstract: An NDIR (Non-Dispersive InfraRed) gas sensor has the LED radiation source (2) and photodiode detector (3) side by side in a dome shaped gas chamber (5). The mirror coated inner surface (6) of the dome (5) reflects light from the LED (2) to the photodiode (3). The reflecting surface in one embodiment has a plurality of semi-toroidal sub surfaces (51-59), such that radiation originating from a point on the LED is unfocussed as it converges on the photodiode. The LED and photodiode (3) may be mounted on a bridge printed circuit board (4) extending along the diameter of the dome housing. The bridge height is adjustable during assembly to optimise the radiation's incidence onto the photodiode.

    Abstract translation: NDIR(非分散红外)气体传感器在圆顶形气体室(5)中并排配置有LED辐射源(2)和光电二极管检测器(3)。 圆顶(5)的镜面涂覆的内表面(6)将来自LED(2)的光反射到光电二极管(3)。 一个实施例中的反射表面具有多个半环形子表面(51-59),使得源自LED上的点的辐射在会聚在光电二极管上时不被聚焦。 LED和光电二极管(3)可以安装在沿着圆顶壳体的直径延伸的桥式印刷电路板(4)上。 桥梁高度在组装期间是可调节的,以优化辐射对光电二极管的入射。

    METHOD AND APPARATUS FOR MONITORING OUTPUT SIGNAL INSTABILITY IN A LIGHT SOURCE
    106.
    发明申请
    METHOD AND APPARATUS FOR MONITORING OUTPUT SIGNAL INSTABILITY IN A LIGHT SOURCE 审中-公开
    用于监测光源中输出信号不稳定性的方法和装置

    公开(公告)号:WO2006059226A1

    公开(公告)日:2006-06-08

    申请号:PCT/IB2005/003718

    申请日:2005-10-29

    Abstract: A spectrophotometric instrument is comprised of a processor, a probe (402) having a tissue engaging surface (404) with an aperture (422) therethrough and a light source producing measurement light signals and optically coupled to the probe via a first optical path (420). A partially reflective first reflecting member (430) is located in the probe and has a generally elliptical profile positioned to reflect a first portion of the measurement light signals to the tissue aperture and to transmit a second portion of the measurement light signals through the first reflecting member. A second reflecting member (456) is located in the probe and has a generally elliptical profile positioned to reflect the measurement light signals transmitted through the first reflecting member. A second optical path (428) has a distal end positioned in the probe to receive to receive light signals transmitted through the tissue sample and a proximal end coupled to the processor.

    Abstract translation: 分光光度仪器包括处理器,探针(402),其具有穿过其中的孔(422)的组织接合表面(404)和产生测量光信号的光源并经由第一光路(420)光学耦合到探针 )。 部分反射的第一反射构件(430)位于探针中并且具有大致椭圆形轮廓,其定位成将测量光信号的第一部分反射到组织孔径,并且通过第一反射透射测量光信号的第二部分 会员。 第二反射构件(456)位于探针中并且具有大致椭圆形轮廓,其被定位成反射通过第一反射构件传输的测量光信号。 第二光路(428)具有定位在探针中的远端以接收以接收透过组织样本的光信号和耦合到处理器的近端。

    マルチスペクトル撮像装置、マルチスペクトル照明装置
    107.
    发明申请
    マルチスペクトル撮像装置、マルチスペクトル照明装置 审中-公开
    多光谱成像系统,多光谱照明系统

    公开(公告)号:WO2005047833A1

    公开(公告)日:2005-05-26

    申请号:PCT/JP2004/016662

    申请日:2004-11-10

    Inventor: 小林 裕昌

    Abstract:  異なる波長の光を発光するLED(23a~23h)と、これらのLED(23a~23h)からの光をリレーする複数の光学ロッド(25)と、これらの光学ロッド(25)からの光を白色拡散面(26a)およびアルミコート反射面(26b)により拡散反射して撮像光軸に対して略60度の角度をなすように照射する光拡散素子(26)と、この光拡散素子(26)からの光をさらに拡散する光学シート(27)と、を有するマルチスペクトル照明装置と、このマルチスペクトル照明装置により照明された被照射面からの反射光を結像し撮像する撮像光学系(21)およびCCD(13)と、を有し、CCD(13)の撮像出力を解析して被照射面の色成分を測定するマルチスペクトル撮像装置。

    Abstract translation: 一种多光谱照明系统,包括发射具有不同波长的光的发光二极管(23a-23h),从这些LED(23a-23h)中继光的多个光棒(25),从所述光扩散元件 通过白色扩散面(26a)和铝涂层反射面(26b)的光学棒(25)和相对成像光轴以大约60°照射的光学棒(25),以及进一步从光线扩散光的光学片 扩散元件(26); 以及具有成像光学系统(21)和CCD(13)的多光谱成像系统,其对从该多光谱照明系统照射的表面成像和拾取反射光,以分析来自CCD的拾取输出 (13)并测量被照射表面的颜色分量。

    SIMULTANEOUS MULTI-BEAM PLANAR ARRAY IR (PAIR) SEPCTROSCOPY
    109.
    发明申请
    SIMULTANEOUS MULTI-BEAM PLANAR ARRAY IR (PAIR) SEPCTROSCOPY 审中-公开
    同时多波束平面阵列IR(对)SEPCTROSCOPY

    公开(公告)号:WO2003031923A1

    公开(公告)日:2003-04-17

    申请号:PCT/US2002/008346

    申请日:2002-03-19

    Abstract: An apparatus (300') and method capable of providing spatially multiplexed IR spectral information simultaneously in real-time for multiple samples or multiple spatial areas of one sample using IR absorption phenomena requires no moving parts or Fourier Transform during operation, and self-compensates for background spectra and degradation of component performance over time. IR spectral information and chemical analysis of the samples is determined by using one or more IR sources (310, 311), one or more sampling accessories (330, 331) for positioning the sample volumes, one or more optically dispersive elements (350), a focal plane array (FPA) (370) arranged to detect the dispersed light beams, and a processor (380) and display (390) to control the FPA (370), and display(390) to control the FPA (370) and display IR spectrograph.

    Abstract translation: 使用IR吸收现象能够对一个样本的多个样本或多个空间区域实时同时提供空间多路复用的红外光谱信息的装置(300')和方法在操作期间不需要移动部件或傅里叶变换,并且自动补偿 背景光谱和组件性能随时间的退化。 通过使用一个或多个IR源(310,311),用于定位样品体积的一个或多个采样附件(330,331),一个或多个光学色散元件(350), 布置成检测分散的光束的焦平面阵列(FPA)(370)以及用于控制FPA(370)的处理器(380)和显示器(390),以及显示器(390)以控制FPA(370)和 显示红外光谱仪。

    ELECTRON MICROSCOPE AND SPECTROSCOPY SYSTEM
    110.
    发明申请
    ELECTRON MICROSCOPE AND SPECTROSCOPY SYSTEM 审中-公开
    电子显微镜和光谱系统

    公开(公告)号:WO2003014794A1

    公开(公告)日:2003-02-20

    申请号:PCT/GB2002/003599

    申请日:2002-08-05

    Applicant: RENISHAW PLC

    Abstract: An electron microscope (10) is adapted to enable spectroscopic analysis of a sample (16). A parabolic mirror (18) has a central aperture (20) through which the electron beam can pass. The mirror (18) focuses laser illumination from a transverse optical path (24) onto the sample, and collects Raman and/or other scattered light, passing it back to an optical system (30). The mirror (18) is retractable (within the vacuum of the electron microscope) by a sliding arm assembly (22). An adjustable kinematic mount (44) defines the inserted position of the parabolic mirror (18). A second parabolic mirror (104) is provided to direct the scattered or generated light towards an optical analyser. The parabolic mirrors are positioned in an aberration cancelling orientation and such that they compensate for inaccuracies in the position of the sliding arm assembly (22).

    Abstract translation: 电子显微镜(10)适于使得能够对样品(16)进行光谱分析。 抛物面镜(18)具有中心孔(20),电子束可以通过该中心孔(20)。 反射镜(18)将来自横向光路(24)的激光照射聚焦到样品上,并收集拉曼和/或其他散射光,将其传回光​​学系统(30)。 镜子(18)通过滑动臂组件(22)可缩回(在电子显微镜的真空内)。 可调节运动学支架(44)限定抛物面镜(18)的插入位置。 提供第二抛物面镜(104)以将散射或产生的光引向光学分析器。 抛物面镜被定位在像差消除取向中,并且使得它们补偿滑动臂组件(22)的位置的不准确性。

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