Abstract:
The present invention relates to an integrated approach to measuring biological samples utilizing a process of eliminating the uninformative or spurious spectral regions which simultaneously removes the necessity for a full spectrograph-CCD system. This approach enables the use of a portable Raman diagnostic system, having significantly reduced size and weight while retaining the required sensitivity. The selection of only a limited number of spectral bands allows the construction of a miniaturized Raman instrument by replacing the spectrograph-CCD combination with an array of optical bandpass filters and light detector(s). One of the embodiments of such a design can incorporate a single photodiode as a light detector. A preferred embodiment of the present invention uses wavelength interval selection based on non-linear representation, such as support vector regression. The wavelength selection protocol is based on the minimization of cross-validation error in the training data. tral information. To acquire the full spectrum necessary for the analysis, a dispersive spectrograph and a CCD detector is typically employed.
Abstract:
The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.
Abstract:
An hyperspectral imaging system that may acquire high resolution spectral and image data in one step, avoiding image registration or image distortion problems, or the need for moving components. The invention employs an optical system that remaps light from normally contiguous elements of an object onto a planar detector in a way that provides interstitial space on the detector between the light from each object element. A dispersion element then generates a spectrum extending into the interstitial space so that the detector simultaneously captures imaging and spectral information. Eliminating the need for moving parts allows perfectly registered and skew-less image and spectral analysis of the skin and allows the practical construction of a rugged handheld device.
Abstract:
An NDIR (Non-Dispersive InfraRed) gas sensor has the LED radiation source (2) and photodiode detector (3) side by side in a dome shaped gas chamber (5). The mirror coated inner surface (6) of the dome (5) reflects light from the LED (2) to the photodiode (3). The reflecting surface in one embodiment has a plurality of semi-toroidal sub surfaces (51-59), such that radiation originating from a point on the LED is unfocussed as it converges on the photodiode. The LED and photodiode (3) may be mounted on a bridge printed circuit board (4) extending along the diameter of the dome housing. The bridge height is adjustable during assembly to optimise the radiation's incidence onto the photodiode.
Abstract:
A compact conical diffraction Littrow spectrometer is disclosed. The distortion of the conically diffracted spectral component beams is compensated and as a result, the diffracted spectral beams can still be focused into a substantially straight line to shine onto a detector array. A spectral domain optical coherence tomography (SD-OCT) system incorporating a Littrow spectrometer or a spectrometer having one or more shared focusing element(s) and an SD-OCT system incorporating a spectrometer that is substantially polarization independent are also disclosed.
Abstract:
A spectrophotometric instrument is comprised of a processor, a probe (402) having a tissue engaging surface (404) with an aperture (422) therethrough and a light source producing measurement light signals and optically coupled to the probe via a first optical path (420). A partially reflective first reflecting member (430) is located in the probe and has a generally elliptical profile positioned to reflect a first portion of the measurement light signals to the tissue aperture and to transmit a second portion of the measurement light signals through the first reflecting member. A second reflecting member (456) is located in the probe and has a generally elliptical profile positioned to reflect the measurement light signals transmitted through the first reflecting member. A second optical path (428) has a distal end positioned in the probe to receive to receive light signals transmitted through the tissue sample and a proximal end coupled to the processor.
Abstract:
The apparatus and methods herein provide light sources and endoscopy systems that can improve the quality of images and the ability of users to distinguish desired features when viewing tissues by providing methods and apparatus that improve the dynamic range of images from endoscopes, in particular endoscopes that have dynamic range limited because of small image sensors and small pixel electron well capacity, and other optical systems.
Abstract:
An apparatus (300') and method capable of providing spatially multiplexed IR spectral information simultaneously in real-time for multiple samples or multiple spatial areas of one sample using IR absorption phenomena requires no moving parts or Fourier Transform during operation, and self-compensates for background spectra and degradation of component performance over time. IR spectral information and chemical analysis of the samples is determined by using one or more IR sources (310, 311), one or more sampling accessories (330, 331) for positioning the sample volumes, one or more optically dispersive elements (350), a focal plane array (FPA) (370) arranged to detect the dispersed light beams, and a processor (380) and display (390) to control the FPA (370), and display(390) to control the FPA (370) and display IR spectrograph.
Abstract:
An electron microscope (10) is adapted to enable spectroscopic analysis of a sample (16). A parabolic mirror (18) has a central aperture (20) through which the electron beam can pass. The mirror (18) focuses laser illumination from a transverse optical path (24) onto the sample, and collects Raman and/or other scattered light, passing it back to an optical system (30). The mirror (18) is retractable (within the vacuum of the electron microscope) by a sliding arm assembly (22). An adjustable kinematic mount (44) defines the inserted position of the parabolic mirror (18). A second parabolic mirror (104) is provided to direct the scattered or generated light towards an optical analyser. The parabolic mirrors are positioned in an aberration cancelling orientation and such that they compensate for inaccuracies in the position of the sliding arm assembly (22).