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    Amide compound and pharmaceutical comprising same
    113.
    发明授权
    Amide compound and pharmaceutical comprising same 有权

    公开(公告)号：US09796677B2

    公开(公告)日：2017-10-24

    申请号：US15100866

    申请日：2014-12-09

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Yohei Soma ,  Tadamasa Arai ,  Takushi Araya

    IPC: A61K31/44 ,  A61K31/505 ,  C07D213/81 ,  C07D239/28 ,  C07D239/30

    CPC classification number: C07D213/81 ,  C07D239/30

    Abstract: Provided is a novel compound which has an excellent Aβ aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

    PREDICTED VALUE SHAPING SYSTEM, CONTROL SYSTEM, PREDICTED VALUE SHAPING METHOD, CONTROL METHOD, AND PREDICTED VALUE SHAPING PROGRAM
    115.
    发明申请
    PREDICTED VALUE SHAPING SYSTEM, CONTROL SYSTEM, PREDICTED VALUE SHAPING METHOD, CONTROL METHOD, AND PREDICTED VALUE SHAPING PROGRAM 审中-公开

    公开(公告)号：US20170235285A1

    公开(公告)日：2017-08-17

    申请号：US15503245

    申请日：2015-09-14

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Shun-ichi Azuma ,  Yuki Minami

    IPC: G05B13/04

    CPC classification number: G05B13/048 ,  G05B11/36 ,  G05B13/04

    Abstract: A predicted value shaping system is provided for calculating a highly accurate control value by shaping of a predicted value. A prediction governor for calculating a control value (v) for controlling a controlled object includes: a result value acquisition unit (22) that acquires a previous target value of the controlled object, that is, a result value (r(t−1)); a predicted value acquisition unit (21) that acquires a predicted value (r (t)) obtained by predicting the target value of the controlled object (12); and a control value calculation unit (23) that calculates a control value (v(t)) for controlling the controlled object (12) by applying the result value (r(t−1)) and the predicted value (r (t)) to a predicted value shaping algorithm (G) to correct the predicted value (r̂(t). The predicted value shaping algorithm (G) uses parameters of a control model (P) of the controlled object (12).

    METHOD FOR DETECTING TARGET MOLECULE AND KIT FOR USE IN SAID METHOD
    117.
    发明申请
    METHOD FOR DETECTING TARGET MOLECULE AND KIT FOR USE IN SAID METHOD 审中-公开

    公开(公告)号：US20170227538A1

    公开(公告)日：2017-08-10

    申请号：US15502652

    申请日：2015-09-09

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Hiroyuki NOJI

    IPC: G01N33/543

    CPC classification number: G01N33/54393 ,  C12Q1/68 ,  G01N33/543

    Abstract: Provided is a method to detect a target molecule, including a complex formation step of reacting a target molecule, a carrier modified with a first antibody which specifically binds to the target molecule, and two or more second antibodies which specifically bind to the target molecule, and are labeled with enzymes having a substrate cleaving activity and mutually different substrate specificities, to form a complex consisting of the first antibody, the target molecule and the second antibodies, on the carrier; and a detection step of reacting two or more substrates having cleavage sites by the enzymes, a fluorescent substance bound to one terminal side of each of the cleavage sites and a quencher bound to another terminal side thereof, wherein the fluorescent substances are mutually different in fluorescence wavelength, and the complex, to detect fluorescence emitted from the fluorescent substances.

    BENZOTHIAZOLE COMPOUND AND MEDICINE CONTAINING SAME
    119.
    发明申请
    BENZOTHIAZOLE COMPOUND AND MEDICINE CONTAINING SAME 有权

    公开(公告)号：US20170197956A1

    公开(公告)日：2017-07-13

    申请号：US15326320

    申请日：2015-07-15

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu KANAI ,  Yohei SOMA ,  Atsuhiko TANIGUCHI ,  Yusuke SHIMIZU

    IPC: C07D455/04 ,  C07D417/04

    CPC classification number: C07D455/04 ,  A61K31/4725 ,  A61K31/4745 ,  A61K38/00 ,  C07D417/04 ,  C07K7/06 ,  C07K14/47

    Abstract: It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to Aβ peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R1 represents an optionally substituted hydrocarbon group; R2 represents a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R2 and R4 optionally together form an alkylene group; and R5 represents an anion.

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