公开(公告)号：MX2009011210A

公开(公告)日：2009-10-30

申请号：MX2009011210

申请日：2008-04-16

Applicant: ABBOTT LAB

Inventor： BRUNCKO MILAN ,  DING HONG ,  KUNZER AARON R ,  ELMORE STEVEN W ,  WANG XILU ,  TAO ZHI-FU ,  SOUERS ANDREW J ,  SONG XIAOHONG ,  MADAR DAVID ,  PARK CHEOL-MIN

IPC: C07D209/42 ,  A61K31/404 ,  A61K31/405 ,  A61P35/00 ,  C07D403/04

Abstract: Se describen compuestos de la fórmula (I), los cuales inhiben la actividad de la proteína Mcl-1 anti-apoptótica, composiciones que contienen los compuestos, y métodos para tratar enfermedades que involucran la proteina Mcl-1 sobre-expresada o desregulada.

公开(公告)号：HK1115055A1

公开(公告)日：2008-11-21

申请号：HK08104997

申请日：2008-05-05

Applicant: ABBOTT LAB

Inventor： WENDT MICHAEL D ,  SHEN WANG ,  DICKMAN DANIEL A ,  DING HONG ,  THOMAS SHEELA A ,  AUGERI DAVID ,  ELMORE STEVEN W

IPC: A61K20060101 ,  A61P20060101 ,  C07C20060101

Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.

公开(公告)号：AU2008242983A1

公开(公告)日：2008-10-30

申请号：AU2008242983

申请日：2008-04-16

Applicant: ABBOTT LAB

Inventor： HASVOLD LISA A ,  SOUERS ANDREW J ,  BRUNCKO MILAN ,  MADAR DAVID ,  ELMORE STEVEN W ,  KUNZER AARON R ,  PARK CHEOL-MIN ,  SONG XIAOHONG ,  WANG LE ,  TAO ZHI-FU ,  WANG XILU ,  WENDT MICHAEL D

IPC: A61K31/404 ,  A61P35/00 ,  C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04

Abstract: 7-substituted indole derivatives which inhibit the activity of anti-apoptotic Mcl-1 protein and compositions containing the compounds are disclosed.

公开(公告)号：SK284689B6

公开(公告)日：2005-09-08

申请号：SK11972000

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COUGHLAN MICHAEL J ,  ELMORE STEVEN W ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K ,  WANG ALAN X ,  EDWARDS JAMES P ,  JONES TODD K

IPC: C07D491/052 ,  A61K31/4738 ,  A61K31/519 ,  A61P29/00 ,  C07D491/04 ,  A61K31/44 ,  A61K31/505

Abstract: Benzopyrano[3,4-f]quinoline compounds of general formula (I), which are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal, and use these compounds for the manufacture of medicaments. Pharmaceutical compositions comprising compounds of general formula (I) are further described.

公开(公告)号：AU766441B2

公开(公告)日：2003-10-16

申请号：AU2677399

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COUGHLAN MICHAEL J ,  ELMORE STEVEN W ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K ,  WANG ALAN X ,  EDWARDS JAMES P ,  JONES TODD K

IPC: C07D491/052 ,  A61K31/4738 ,  A61K31/519 ,  A61P29/00 ,  C07D491/04 ,  A61K31/44 ,  A61K31/505

公开(公告)号：CA2479362A1

公开(公告)日：2003-10-02

申请号：CA2479362

申请日：2003-03-14

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  WANG XILU ,  PARK CHEOL-MIN

IPC: C07D295/20 ,  A61K31/4418 ,  A61K31/4422 ,  A61K31/495 ,  A61K31/5377 ,  A61P25/18 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D211/16 ,  C07D211/18 ,  C07D211/26 ,  C07D211/58 ,  C07D211/82 ,  C07D211/90 ,  C07D295/215

Abstract: Compounds having the formula (I) are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：ES2192035T3

公开(公告)日：2003-09-16

申请号：ES99906996

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COUGHLAN MICHAEL J ,  ELMORE STEVEN W ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K

IPC: C07D491/052 ,  A61K31/4738 ,  A61K31/519 ,  A61P29/00 ,  C07D491/04 ,  A61K31/44 ,  A61K31/505

公开(公告)号：DK1053239T3

公开(公告)日：2003-04-22

申请号：DK99906996

申请日：1999-02-12

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： COUGHLAN MICHAEL J ,  KORT MICHAEL E ,  KYM PHILIP R ,  MOORE JIMMIE L ,  PRATT JOHN K ,  WANG ALAN X ,  EDWARDS JAMES P ,  JONES TODD K ,  ELMORE STEVEN W

IPC: C07D491/052 ,  A61K31/4738 ,  A61K31/519 ,  A61P29/00 ,  C07D491/04 ,  A61K31/44 ,  A61K31/505

公开(公告)号：BG106679A

公开(公告)日：2003-01-31

申请号：BG10667902

申请日：2002-05-09

Applicant: ABBOTT LAB

Inventor： ELMORE STEVEN W ,  COOPER CURT S ,  SCHULTZ COLLEEN C ,  HUTCHINSON DOUGLAS K ,  DONNER PAMELA L ,  GREEN BRIAN E ,  ANDERSON DAVID D ,  XIE QINGHUA ,  DINGES JURGEN ,  LYNCH LINDA M

IPC: A61K31/4375 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/542 ,  A61P31/04 ,  A61P43/00 ,  C07B61/00 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  A61K31/4709 ,  C07D417/04

Abstract: Compounds having the formula are pharmaceutically acceptable salts or prodrugs thereof, are useful as antibacterial agents. 21 claims

公开(公告)号：CA2415037A1

公开(公告)日：2002-01-10

申请号：CA2415037

申请日：2001-06-27

Applicant: ABBOTT LAB ,  LIGAND PHARM INC

Inventor： KORT MICHAEL E ,  COGHLAN MICHAEL J ,  EDWARDS JAMES P ,  JONES TODD K ,  KYM PHILIP R ,  MOORE JIMMIE L ,  ELMORE STEVEN W ,  WANG ALAN X ,  PRATT JOHN K

IPC: C07D491/052 ,  A61K31/4741 ,  A61K31/519 ,  A61K31/5377 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D491/04 ,  A61K31/435 ,  A61K31/505

Abstract: Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.