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公开(公告)号：HRP20000650A2
公开(公告)日：2001-06-30
申请号：HRP20000650
申请日：2000-10-03
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/22 , A61K31/192 , A61K31/216 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07C59/66 , C07C59/68 , C07C69/734 , C07D213/63 , C07D239/34 , C07D239/52 , C07D239/60 , C07D405/12 , C07D491/048 , C07D403/12 , C07D213/64
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein R -R , Q, W, X, Y and Z have the meanings given in the description. The novel compounds are suitable for combating diseases.
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公开(公告)号：HU0002714A2
公开(公告)日：2001-05-28
申请号：HU0002714
申请日：1998-06-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , HERGENROEDER STEFAN , KLING ANDREAS , KLINGE DAGMAR , RASCHACK MANFRED , RIECHERS HARTMUT , UNGER LILIANE
IPC: C07D251/16 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61P7/02 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P25/06 , A61P35/00 , A61P35/04 , A61P43/00 , C07C247/12 , C07D213/68 , C07D237/14 , C07D237/16 , C07D239/34 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/95 , C07D241/18 , C07D251/22 , C07D251/34 , C07D251/52 , C07D253/06 , C07D403/12 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.
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公开(公告)号：HU0001758A2
公开(公告)日：2001-05-28
申请号：HU0001758
申请日：1998-03-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , HAUPT ANDREAS , JANSSEN BERND , KLING ANDREAS DR , RITTER KURT
Abstract: The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,A-B-D-E-F-G(I)A, B, D, and E are alpha -amino acid residues. In one embodiment, F is an azacycloalkanecarboxylic acid residue. In this embodiment, G is a monovalent radical, for example, a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group. In another embodiment, F is an azacycloalkyl group and G is a heteroaryl group connected to F by a carbon-carbon bond. In another embodiment, the invention includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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公开(公告)号：SK11752000A3
公开(公告)日：2001-05-10
申请号：SK11752000
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/22 , A61K31/192 , A61K31/216 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07C59/66 , C07C59/68 , C07C69/734 , C07D213/63 , C07D239/34 , C07D239/52 , C07D239/60 , C07D405/12 , C07D491/048 , C07D403/12 , C07D213/64
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein R -R , Q, W, X, Y and Z have the meanings given in the description. The novel compounds are suitable for combating diseases.
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公开(公告)号：AU731579B2
公开(公告)日：2001-04-05
申请号：AU2636597
申请日：1997-04-04
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , BAUMANN ERNST , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENRODER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044
Abstract: The present invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs.
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Patent Agency Ranking116.发明专利
公开(公告)号：BG104396A
公开(公告)日：2001-02-28
申请号：BG10439600
申请日：2000-05-02
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61P9/02 , A61P9/10 , A61P9/12 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/60 , C07D239/70 , C07D401/12 , C07D403/12 , C07D491/048
Abstract: The invention relates to derivatives of carboxylic acids with the formula wherein R6 is the group or R13 and R14 are the same or different meaning hydrogen provided that R13 and R14 are not simultaneously hydrogen, C1-C8-alkyl, C3-C8-cycloalkyl, C3-C8-alkenyl, C3-C8-alkynyl, benzyl, phenyl, naphthyl, optionally substituted, or R13 and R14 together form a closed in a ring C3-C7-alkylene chain, optionally substituted, and in which an alkylene group can be substituted with oxygen, sulphur, nitrogen, or R13 and R14 together form a closed in a ring C3-C7-alkylene chain, or C4-C7-alkenyl chain, optionally substituted, which can be with a phenyl ring, optionally substituted. The remaining substituents have the meanings given in the description. The invention also relates to new derivatives of carboxylic acids and to their use as endothelin-receptor antagonists. 14 claims
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公开(公告)号：AU6561500A
公开(公告)日：2001-02-05
申请号：AU6561500
申请日：2000-07-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , KETTSCHAU GEORG
IPC: A61K31/505 , A61K31/506 , A61K31/517 , A61P1/18 , A61P5/16 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/47 , C07D239/52 , C07D239/56 , C07D239/70 , C07D239/80 , C07D401/12 , C07D405/12 , C07D409/12 , C07D473/28 , C07D403/12
Abstract: The invention relates to compounds of formula (I), whereby the substituents have the meaning cited in the description. The invention also relates to the utilization of said derivatives.
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公开(公告)号：AU729333B2
公开(公告)日：2001-02-01
申请号：AU7495796
申请日：1996-10-30
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MULLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：SK12012000A3
公开(公告)日：2001-01-18
申请号：SK12012000
申请日：1999-02-25
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLINGE DAGMAR
IPC: A61K31/19 , A61K31/215 , C07D239/38 , A61K31/357 , A61K31/36 , A61K31/505 , A61P43/00 , C07C319/14 , C07C323/56 , C07D239/56 , C07D239/60 , C07D317/62 , C07C323/00
Abstract: A process for preparing endothelin receptor antagonists of the sulfanyl type of the general formula Iby nucleophilic reaction of a carboxylic acid derivative of the formula II with a sulfide of the formula IIIto give endothelin receptor antagonists of the formula I.
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公开(公告)号：TR200002376T2
公开(公告)日：2000-12-21
申请号：TR200002376
申请日：1999-02-05
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61P5/14 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the following meanings; R = tetrazole or a group (1); R = a radical OR (2), (3), a 5-membe red heteroaromatic bonded by a nitrogen atom such a pyrrolyl, pyrazolyl, imidazolyl and trizolyl; R , R = hydrogen, hydroxy, NH2, NH(C1-C4-alkyl), N(C1-C4-alkyl)2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkinyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy, C1-C4-halogen alkyl, C1-C4-alkoxy, C1-C4-halogen alkoxy or C1-C4-alkythio; X = halogen, C1-C4-halogen alkyl, hydroxy; R and R = phenyl or naphthyl, C3-C7-cycloalkyl, phenyl or naphthyl which are bonded in ortho position by a direct bond, a methylene, ethylene or ethenylene group, an oxygen or sulfur atom or an SO2-NH or an N-alkyl group or a 5-membered or 6-membered heteroaromatic; R = hydrogen, phenyl or naphthyl, a five or six-membered heteroaromatic, C1-C8-alkyl, C3-C6-alkenyl, C3-C6-alkinyl or C3-C8-cycloalkyl, whereby said radicals can be substituted once or many times, with the proviso that R can only stand for hydrogen if Z does not represent a single bond; Z = sulfur, oxygen or a single bond, in addition to the physiologically compatible salts and the enantiomeric-pure and diastereomeric-pure forms. The novel compounds are suitable for combating diseases, especially as endothelin antagonists.
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