公开(公告)号：BRPI0808555A2

公开(公告)日：2014-08-19

申请号：BRPI0808555

申请日：2008-02-27

Applicant: BASF SE

Inventor： ZIERKE THOMAS ,  RACK MICHAEL

IPC: C07C241/02

Abstract: This invention relates to a process for preparing substituted phenylhydrazines of the formula I wherein R has the meaning as indicated in the description, comprising reacting a dichlorofluorobenzene of the formula II with a hydrazine source selected from hydrazine, hydrazine hydrate and acid addition salts of hydrazine and optionally being carried out in the presence of at least one organic solvent.

公开(公告)号：AU2008263883B2

公开(公告)日：2014-03-13

申请号：AU2008263883

申请日：2008-06-13

Applicant: BASF SE

Inventor： LOHMANN JAN KLAAS ,  NETT MARKUS ,  SMIDT SEBASTIAN PEER ,  ZIERKE THOMAS ,  GROTE THOMAS ,  RACK MICHAEL ,  DIETZ JOCHEN

IPC: C07D231/12 ,  C07D231/14

Abstract: The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R

公开(公告)号：AU2008257515B2

公开(公告)日：2014-01-23

申请号：AU2008257515

申请日：2008-05-30

Applicant: BASF SE

Inventor： SMIDT SEBASTIAN PEER ,  RHEINHEIMER JOACHIM ,  CHALLAND NINA ,  RACK MICHAEL ,  SCHMIDT-LEITHOFF JOACHIM ,  ZIERKE THOMAS ,  ALTENHOFF ANSGAR GEREON

IPC: C07D231/14

Abstract: The present invention relates to a method for the production of n-substituted (3-dihalomethyl-1-methyl-pyrazole-4-YL) carboxamides of the formula (I), wherein R

公开(公告)号：MX317270B

公开(公告)日：2014-01-20

申请号：MX2010011276

申请日：2009-05-06

Applicant: BASF SE

Inventor： KEIL MICHAEL ,  WOLF BERND ,  ZIERKE THOMAS ,  RACK MICHAEL ,  MAYWALD VOLKER ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  REICHERT WOLFGANG

Abstract: A process for preparing arylcarboxamides of the formula (I) where Ar=a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C1-C4-alkyl and C1-C4-haloalkyl; M=thienyl or phenyl, which may bear a halogen substituent; Q=direct bond, cyclopropylene, fused bicyclo[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R1=hydrogen, halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in an approximately stoichiometric amount and d) the product of value is isolated.

公开(公告)号：ES2386940T3

公开(公告)日：2012-09-06

申请号：ES09738223

申请日：2009-04-30

Applicant: BASF SE

Inventor： ZIERKE THOMAS ,  MAYWALD VOLKER ,  RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  KEIL MICHAEL ,  WOLF BERND ,  KORADIN CHRISTOPHER

IPC: C07D231/14 ,  C07D295/145

Abstract: Método para la preparación de compuestos de la fórmula (I), **Fórmula**dondeR1 representa alquilo de C1-C6, haloalquilo de C1-C6, alquenilo de C2-C6, cicloalquilo de C3-C10 o bencilo, en cuyocaso ambos residuos mencionados de último están sin sustituir o tienen 1, 2 o 3 sustituyentes seleccionadosindependientemente entre sí de halógeno, CN, nitro, alquilo de C1-C4, haloalquilo de C1-C4, alcoxi de C1-C4 yhaloalcoxi de C1-C4;R2 y R3, independientemente entre sí, representan alquilo de C1-C6, haloalquilo de C1-C6, alquenilo de C2-C6,cicloalquilo de C3-C10 o bencilo, en cuyo caso los dos residuos mencionados de último están sin sustituir o tienen o1, 2 o 3 sustituyentes seleccionados independientemente entre sí de entre halógeno, CN, nitro, alquilo de C1-C4,haloalquilo de C1-C4, alcoxi de C1-C4 y haloalcoxi de C1-C4; oR2 conjuntamente con R3 y el átomo de nitrógeno al cual ambos residuos están enlazados representan un residuoheterocíclico de 5 a 10 miembros opcionalmente sustituidos, el cual puede comprender, además del átomo denitrógeno, 1, 2 o 3 heteroátomos más seleccionados entre O, N y S en calidad de miembros de anillo;R4 representa hidrógeno, flúor o cloro; yX1 y X2, independientemente entre sí, representan flúor o cloro;En el cual se hace reaccionar un compuesto de la fórmula (II),donde R1, R2 y R3 tienen uno de los significados dados previamente; con un compuesto de la fórmula X1X2R420 CC(>=O)-F en presencia de al menos un fluoruro de metal alcalino o de metal alcalino térreo.

公开(公告)号：AU2007316081B2

公开(公告)日：2012-04-26

申请号：AU2007316081

申请日：2007-11-02

Applicant: BASF SE

Inventor： ZIERKE THOMAS ,  RACK MICHAEL ,  GROTE THOMAS ,  LOHR SANDRA ,  DIETZ JOCHEN ,  RHEINHEIMER JOACHIM ,  SMIDT SEBASTIAN PEER ,  SUKOPP MARTIN ,  LOHMANN JAN KLAAS ,  KEIL MICHAEL

IPC: C07D237/04 ,  C07F7/04

Abstract: The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-yl carboxylates of the formula (I) in which R is C-C-alkyl, C-C-cycloalkyl, C-C-alkoxy-C-C-alkyl, etc.; and R is hydrogen, C-C-alkyl, benzyl or phenyl, wherein a) a compound of the general formula (II) in which X is fluorine, chlorine, or bromine, R has one of the definitions given above, and R is C-C-alkyl, C-C-cycloalkyl, C-C-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R SiClin which n is 1, 2 or 3 and the substituents R are each independently selected from C-C-alkyl and phenyl, and with a metal which is selected from the metals of groups 1, 2, 3, 4 and 12 of the periodic table and has a redox potential of less than -0.7 V, based on a standard hydrogen electrode (at 25°C and 101.325 kPa); and b) the reaction mixture from step a) is reacted with a compound of the general formula (III) in which R has one of the definitions given above.

公开(公告)号：ZA201100690B

公开(公告)日：2012-04-25

申请号：ZA201100690

申请日：2011-01-27

Applicant: BASF SE

Inventor： ZIERKE THOMAS ,  ENGEL STEFAN

IPC: C07B20060101 ,  C07C20060101

Abstract: The present invention relates to a process for the isomerization of the Z-isomer I-Z of a semicarbazone compound of the general formula (I) into its E-isomer I-E wherein the variables in formula (I) have the meanings as defined in the description.

公开(公告)号：UA97498C2

公开(公告)日：2012-02-27

申请号：UAA200904967

申请日：2007-11-02

Applicant: BASF SE

Inventor： RACK MICHAEL ,  SMIDT SEBASTIAN PEER ,  LOEHR SANDRA ,  KEIL MICHAEL ,  DIETZ JOCHEN ,  RHEINHEIMER JOACHIM ,  GROTE THOMAS ,  ZIERKE THOMAS ,  LOHMANN JAN KLAAS ,  SUKOPP MARTIN

IPC: C07D237/04 ,  C07F7/04

Abstract: Данноеизобретениекасаетсяспособаполучениядифторметилзамещенныхпиразол-4-илкарбоксилатовформулы I, (I)вкоторойRозначает C-C-алкил, С-С-циклоалкил, С-С-алкокси-С-С-алкили т.п.; иRозначаетводород, С-С-алкил, бензилилифенил,причема) соединениеобщейформулы II, (II)вкоторой X означаетфтор, хлорилибром, Rимеетодноизприведенныхпреждезначенийи RозначаетС-С-циклоалкил, С-С-алкенил, бензилилифенил,взаимодействуетс силановымсоединениемобщейформулы RSiCl, вкоторой n означает 1, 2 или 3 изаместители R, независимодруготдругавыбраныизС-С-алкилаилифенила, ис металлом, которыйвыбранизметаллов 1, 2, 3, 4 и 12 группыПериодическойсистемыэлементови имеетокислительно-восстановительныйпотенциалменьшечем-0,7 V, вперечислениинанормальныйводородныйэлектро

公开(公告)号：AT520667T

公开(公告)日：2011-09-15

申请号：AT08761025

申请日：2008-06-13

Applicant: BASF SE

Inventor： NETT MARKUS ,  GROTE THOMAS ,  LOHMANN JAN KLAAS ,  DIETZ JOCHEN ,  SMIDT SEBASTIAN PEER ,  RACK MICHAEL ,  ZIERKE THOMAS

IPC: C07D231/12 ,  C07D231/14

Abstract: The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

公开(公告)号：MX2010011276A

公开(公告)日：2010-11-09

申请号：MX2010011276

申请日：2009-05-06

Applicant: BASF SE

Inventor： KEIL MICHAEL ,  WOLF BERND ,  ZIERKE THOMAS ,  RACK MICHAEL ,  MAYWALD VOLKER ,  KORADIN CHRISTOPHER ,  SMIDT SEBASTIAN PEER ,  REICHERT WOLFGANG

IPC: C07D213/82 ,  C07C231/02 ,  C07C233/57 ,  C07C233/64 ,  C07D231/14 ,  C07D231/16

Abstract: Procedimiento para la obtención de arilcarboxamidas de la fórmula (I) (ver formula (I)) en la que Ar = es un anillo fenilo, piridilo o pirazolilo mono a trisustituido, seleccionando los sustituyentes de halógeno, C1-C4-alquilo y C1-C4-halógenoalquilo; M = es tienilo o fenilo, que puede llevar un sustituyente halógeno; Q = es un enlace directo, ciclopropileno, un anillo biciclo(2.2.1]heptano o biciclo[2.2.1]hepteno anelado; R1 = es hidrógeno, halógeno, C1-C6-alquilo, C1-C4-alcoxi, C1-C4-halógenoalcoxi, fenilo mono a trisustituido, seleccionando los sustituyentes de halógeno y trifluorometiltio, o ciclopropilo; transformando un cloruro de ácido de la fórmula (II) (ver fórmula (II) con una arilamina (III) (ver fórmulas (III)) en un solvente no soluble en agua apropiado, en cuyo procedimiento a) se presenta el cloruro de ácido (II) como carga inicial en presencia de una base auxiliar, b) se regula una presión de 0 hasta 700 mbar, c) se dosifica la arilamina (III) en cantidad aproximadamente estequiométrica y d) se aísla el producto de valor.