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111.发明专利
公开(公告)号：DK3027602T3
公开(公告)日：2018-09-24
申请号：DK14758604
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： HENLIN JEAN-MICHEL , LETIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , WALMSLEY CLAIRE , CASARA PATRICK , CHEN I-JEN , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON , LE DIGUARHER THIERRY , STARCK JÉRÔME-BENOÎT
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
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112.发明专利
公开(公告)号：MD4490C1
公开(公告)日：2018-01-31
申请号：MD20140084
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Invenţia se referă la noi compuşi indolizinici care pot fi utilizaţi în tratamentul bolilor oncologice şi celor legate de apoptoză.Se revendică compuşi cu formula (I) şi un procedeu de obţinere a lor:unde Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5,, X, Y şi Het sunt definiţi în descriere.De asemenea se revendică compoziţii farmaceutice care conţin un compus cu formula (I) sau o sare de adiţie a acestuia cu un acid sau o bază acceptabilă farmaceutic; şi utilizarea compoziţiilor farmaceutice respective în fabricarea medicamentelor.Revendicări: 24
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113.发明专利
公开(公告)号：ME02601B
公开(公告)日：2017-06-20
申请号：MEP201728
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: A61K31/4353 , A61K31/407 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
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114.发明专利
公开(公告)号：AU2013213474B2
公开(公告)日：2017-06-08
申请号：AU2013213474
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JEROME-BENOIT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STEPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Compounds of formula (I) wherein R
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公开(公告)号：SI2807159T1
公开(公告)日：2017-03-31
申请号：SI201330535
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JEROME-BENOIT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STEPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/00 , A61K31/00 , A61P35/00 , A61P37/00 , C07D487/00 , C07D491/00
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Patent Agency Ranking116.发明专利
公开(公告)号：HRP20170153T1
公开(公告)日：2017-03-24
申请号：HRP20170153
申请日：2017-01-31
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STÉPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D471/04 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D487/04 , C07D491/052
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117.发明专利
公开(公告)号：NZ626942A
公开(公告)日：2016-07-29
申请号：NZ62694213
申请日：2013-01-23
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DEPIL STÉPHANE , CASARA PATRICK , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME , LE DIGUARHER THIERRY
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Disclosed herein are substituted indolizine compounds of formula (I) that are useful as pro-apoptotic agents, wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5; X, Y and Het are as defined in the specification. These compounds are suitable for the treatment of cancers of the bladder, brain, breast and uterus, chronic lymphoid leukaemias, cancer of the colon, oesophagus and liver, lymphoblastic leukaemias, follicular lymphomas, melanomas, malignant haemopathies, myelomas, ovarian cancer, non-small-cell lung cancer, prostate cancer and small-cell lung cancer.
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公开(公告)号：MX2016000900A
公开(公告)日：2016-05-05
申请号：MX2016000900
申请日：2014-07-22
Applicant: SERVIER LAB
Inventor： NANTEUIL GUILLAUME DE , CASARA PATRICK , DIGUARHER THIERRY LE , GENESTE OLIVIER , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , CHEN I-JEN , GRAHAM CHRISTOPHER JOHN , TIRAN ARNAUD LE , WALMSLEY CLAIRE , RAY STUART , MADDOX DANIEL , BEDFORD SIMON , MURRAY JAMES BROOKE
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
Abstract: Compuestos de fórmula (I): (ver Fórmula) en la que Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T y W son tales como se han definido en la descripción.
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119.发明专利
公开(公告)号：HK1201527A1
公开(公告)日：2015-09-04
申请号：HK15102089
申请日：2015-03-02
Applicant: SERVIER LAB
Inventor： LE DIGUARHER THIERRY , CASARA PATRICK , STARCK JRME-BENOT , HENLIN JEAN-MICHEL , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , CHEN I-JEN , GENESTE OLIVIER , HICKMAN JOHN , DEPIL STPHANE , LE TIRAN ARNAUD , NYERGES MIKLOS , DE NANTEUIL GUILLAUME
IPC: C07D20060101 , A61K20060101 , A61P20060101
Abstract: wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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120.发明专利
公开(公告)号：MX2014008913A
公开(公告)日：2015-01-19
申请号：MX2014008913
申请日：2013-01-23
Applicant: SERVIER LAB
Inventor： HICKMAN JOHN , CASARA PATRICK , DIGUARHER THIERRY LE , GENESTE OLIVIER , STARCK JÉRÔME-BENOÎT , NANTEUIL GUILLAUME DE , HENLIN JEAN-MICHEL , DEPIL STÉPHANE , DAVIDSON JAMES EDWARD PAUL , CHEN I-JEN , NYERGES MIKLOS , MURRAY JAMES BROOKE , GRAHAM CHRISTOPHER JOHN , TIRAN ARNAUD LE
IPC: C07D471/00 , A61K31/407 , A61K31/4353 , A61K31/436 , A61P35/00 , A61P37/00 , C07D471/04 , C07D487/04 , C07D491/052
Abstract: Compuestos de fórmula (I): (ver Fórmula) en la que Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y y Het son tales como se han definido en la descripción.
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