公开(公告)号：CZ371396A3

公开(公告)日：1997-10-15

申请号：CZ371396

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078

Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.

公开(公告)号：ZA961276B

公开(公告)日：1997-08-19

申请号：ZA961276

申请日：1996-02-19

Applicant: BASF AG

Inventor： BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K20060101 ,  C07K20060101 ,  C12N20060101 ,  C07K ,  A61K ,  C12N

公开(公告)号：FI973282A0

公开(公告)日：1997-08-08

申请号：FI973282

申请日：1997-08-08

Applicant: BASF AG

Inventor： SEITZ WERNER ,  MACK HELMUT ,  ZIERKE THOMAS ,  BOEHM HANS-JOACHIM ,  HOEFFKEN HANS WOLFGANG ,  KOSER STEFAN ,  PFEIFFER THOMAS ,  HORNBERGER WILFRIED

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/087 ,  C07K

Abstract: PCT No. PCT/EP96/00472 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24609 PCT Pub. Date Aug. 15, 1996Thrombin inhibitors of the formula where R1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described. The compounds I are suitable for controlling diseases.

公开(公告)号：AU679811B2

公开(公告)日：1997-07-10

申请号：AU1067095

申请日：1994-11-25

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：MX9606521A

公开(公告)日：1997-05-31

申请号：MX9606521

申请日：1995-06-06

Applicant: BASF AG

Inventor： BOHM HANS-JOACHIM ,  KOSER STEFAN ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  WOLFGANG HANS ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K38/00 ,  A61K38/05 ,  A61K38/55 ,  A61K47/48 ,  A61P7/02 ,  C07C279/00 ,  C07D205/04 ,  C07D207/06 ,  C07D207/16 ,  C07D207/48 ,  C07D211/60 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K05/06

Abstract: Se describen compuestos de la formula (Ver Formula) y las sales de los mismos con ácidos fisiologicamente tolerados y los estereoisomeros de los mismos, en donde los sustituyentes tienen los significados indicados en la descripcion. Se presentan también productos intermedios para su preparacion. Los compuestos son adecuados para controlar enfermedades.

公开(公告)号：CA2211109A1

公开(公告)日：1996-08-22

申请号：CA2211109

申请日：1996-02-12

Applicant: BASF AG

Inventor： PFEIFFER THOMAS ,  ZIERKE THOMAS ,  B HM HANS-JOACHIM ,  SEITZ WERNER ,  KOSER STEFAN ,  HORNBERGER WILFRIED ,  H FFKEN HANS WOLFGANG ,  MACK HELMUT

IPC: A61K31/00 ,  A61K38/55 ,  A61P7/02 ,  C07D205/04 ,  C07D207/16 ,  C07D213/53 ,  C07D213/63 ,  C07D213/72 ,  C07D213/78 ,  C07D213/79 ,  C07D239/28 ,  C07D241/14 ,  C07D241/24 ,  C07D401/12 ,  C07K5/06 ,  C07K5/062 ,  C07K5/078 ,  C07J43/00 ,  A61K38/05 ,  C07F7/10 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D405/14 ,  C07D217/26 ,  A61K31/40 ,  A61K31/435 ,  C07F9/547 ,  C07C255/58 ,  A61K31/58 ,  C07D211/60 ,  A61K31/675 ,  A61K31/695 ,  C07D213/81 ,  C07D213/84

Abstract: The description relates to compounds of formula (I) in which A, B, D, R1 and R2 have the meanings given in the specification. The compounds are suitable for the treatment of diseases. The novel compounds are produced via compounds of the formula H2N-CH2-G-M in which G and M have the meanings given in claim 4.

公开(公告)号：NO962261A

公开(公告)日：1996-05-31

申请号：NO962261

申请日：1996-05-31

Applicant: BASF AG

Inventor： SCHWEDEN JURGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

CPC classification number: A61K47/545 ,  A61K38/00 ,  A61K47/54

公开(公告)号：FI962299A0

公开(公告)日：1996-05-31

申请号：FI962299

申请日：1996-05-31

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02 ,  C07K

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：ES2071343T3

公开(公告)日：1995-06-16

申请号：ES91920137

申请日：1991-11-21

Applicant: BASF AG

Inventor： SCHMIED BERNHARD ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  BERNARD HARALD

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K7/06 ,  C07K14/815

Abstract: PCT No. PCT/EP91/02191 Sec. 371 Date Jul. 29, 1993 Sec. 102(e) Date Jul. 29, 1993 PCT Filed Nov. 21, 1991 PCT Pub. No. WO92/13879 PCT Pub. Date Aug. 20, 1992.Peptides of the formula where X, A1-A7 Y and W have the meanings stated in the description, and the preparation thereof are described. The peptides are suitable for controlling diseases.

公开(公告)号：AT121422T

公开(公告)日：1995-05-15

申请号：AT91920137

申请日：1991-11-21

Applicant: BASF AG

Inventor： SCHMIED BERNHARD ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED ,  BERNARD HARALD

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  C07K7/06 ,  C07K14/815

Abstract: PCT No. PCT/EP91/02191 Sec. 371 Date Jul. 29, 1993 Sec. 102(e) Date Jul. 29, 1993 PCT Filed Nov. 21, 1991 PCT Pub. No. WO92/13879 PCT Pub. Date Aug. 20, 1992.Peptides of the formula where X, A1-A7 Y and W have the meanings stated in the description, and the preparation thereof are described. The peptides are suitable for controlling diseases.