公开(公告)号：AU2006208414A1

公开(公告)日：2006-09-28

申请号：AU2006208414

申请日：2006-09-08

Applicant: HARVARD COLLEGE

Inventor： CHERNIAVSKAYA OKSANA ,  ANDERSON JANELLE R ,  MCDONALD COOPER ,  JACKMAN REBECCA J ,  CHIU DANIEL T ,  WHITESIDES GEORGE M

IPC: B01L3/00 ,  B01F13/00 ,  B29C31/04 ,  B29C33/40 ,  B29C33/42 ,  B29C39/02 ,  B29C39/24 ,  B29C65/00 ,  B81B1/00 ,  B81C1/00

公开(公告)号：AU2005209321A1

公开(公告)日：2005-08-11

申请号：AU2005209321

申请日：2005-01-26

Applicant: HARVARD COLLEGE

Inventor： LINDER VINCENT ,  SIEGEL ADAM ,  SIA SAMUEL K ,  PARVIZ BABAK AMIR ,  WHITESIDES GEORGE M

IPC: B01J4/02 ,  B01L3/00

公开(公告)号：AU2002319668A1

公开(公告)日：2003-02-17

申请号：AU2002319668

申请日：2002-07-24

Applicant: HARVARD COLLEGE

Inventor： DERTINGER STEPHAN K W ,  MEZIC IGOR ,  STROOCK ABRAHAM D ,  WHITESIDES GEORGE M ,  AJDARI ARMAND ,  STONE HOWARD A

IPC: B01F5/00 ,  B01F5/06 ,  B01F13/00 ,  G01N27/447 ,  B81C1/00 ,  B81B1/00 ,  B01L3/00 ,  B01J19/00

Abstract: A mixing apparatus is used to effect mixing between one or more fluid streams. The mixing apparatus generally functions by creating a transverse flow component in the fluid flowing within a channel without the use of moving mixing elements. The transverse or helical flow component of the flowing fluid or fluids can be created by weak modulations of the shape of the walls of the channel. Transverse or helical flow component can be created by grooves features defined on the channel wall. Specifically, the present invention can be used in laminarly flowing fluids. The mixing apparatus and methods thereof can effect mixing of a fluid or fluids flowing with a Reynolds number of less than about 100. Thus, the present invention can be used to mix a fluid flowing in the micro-regime. The mixing apparatus can be used to mix a fluid in a microfluidic system to significantly reduce the Taylor dispersion along the principal direction. The mixing apparatus can be used to increase the effective exposed area to promote diffusion of components between or within the fluid or fluids.

公开(公告)号：CA2415294A1

公开(公告)日：2002-01-24

申请号：CA2415294

申请日：2001-07-17

Applicant: HARVARD COLLEGE

Inventor： LIANG MICHAEL N ,  OSTUNI EMANUELE ,  WHITESIDES GEORGE M ,  YAN LIN ,  CHAPMAN ROBERT G

IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  C09D5/14

Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free o f a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non- specific binding of biomolecules.

公开(公告)号：CA2410062A1

公开(公告)日：2001-11-29

申请号：CA2410062

申请日：2001-05-25

Applicant: HARVARD COLLEGE

Inventor： CHIU DANIEL T ,  ANDERSON JANELLE R ,  WHITESIDES GEORGE M ,  MCDONALD COOPER ,  JACKMAN REBECCA J ,  CHERNIAVSKAYA OKSANA

IPC: G01N37/00 ,  B01F13/00 ,  B01L3/00 ,  B01L3/02 ,  B29C31/04 ,  B29C33/40 ,  B29C33/42 ,  B29C39/02 ,  B29C39/24 ,  B29C65/00 ,  B81B1/00 ,  B81C1/00 ,  B82B3/00 ,  C12M1/34 ,  B01J4/00

Abstract: The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.

公开(公告)号：AU2324797A

公开(公告)日：1997-10-01

申请号：AU2324797

申请日：1997-03-14

Applicant: HARVARD COLLEGE

Inventor： KIM ENOCH ,  XIA YOUNAN ,  MRKSICH MILAN ,  JACKMAN REBECCA JANE ,  WHITESIDES GEORGE M

IPC: A61K9/51 ,  A61K47/48 ,  B01J19/00 ,  B29C31/04 ,  B29C33/42 ,  B29C37/00 ,  B29C39/24 ,  B29C67/24 ,  B81C1/00 ,  C40B60/14 ,  H05K3/00 ,  H05K3/06

公开(公告)号：AU6774996A

公开(公告)日：1997-03-12

申请号：AU6774996

申请日：1996-08-16

Applicant: HARVARD COLLEGE

Inventor： CLEM PAUL G ,  JEON NOO-LI ,  MRKSICH MILAN ,  NUZZO RALPH G ,  PAYNE DAVID A ,  WHITESIDES GEORGE M ,  XIA YOUNAN

IPC: B05D1/28 ,  B41M3/00 ,  C23C16/01 ,  C23C16/04 ,  C40B60/14 ,  G03F7/00 ,  H01L21/285 ,  H01L21/768 ,  B05D1/18

Abstract: A technique for creating patterns of material deposited on a surface involves forming a self-assembled monolayer in a pattern on the surface and depositing, via chemical vapor deposition or via sol-gel processing, a material on the surface in a pattern complementary to the self-assembled monolayer pattern. The material can be a metal, metal oxide, or the like. The surface can be contoured, including trenches or holes, the trenches or holes remaining free of self-assembled monolayer while the remainder of the surface is coated. When exposed to deposition conditions, metal or metal oxide is deposited in the trenches or holes, and remaining portions of the article surface remain free of deposition. The technique finds particular use in creation of conductive metal pathways selectively within holes passing from one side of a substrate to another.

公开(公告)号：EP3183099A4

公开(公告)日：2018-06-13

申请号：EP15834529

申请日：2015-08-21

Applicant: HARVARD COLLEGE

Inventor： LESSING JOSHUA AARON ,  WHITESIDES GEORGE M ,  MARTINEZ RAMSES V ,  YANG DIAN ,  MOSADEGH BOBAK ,  GALLOWAY KEVIN C ,  GUDER FIRAT ,  TAYI ALOK SURYAVAMSEE

IPC: B25J9/00 ,  B25J9/14 ,  B25J15/00 ,  B25J15/12 ,  G06F19/00

CPC classification number: B25J18/06 ,  B25J9/142 ,  B25J13/085 ,  B25J13/087 ,  B25J13/088 ,  B25J15/0009 ,  B25J15/12

Abstract: A soft robotic device with one or more sensors is described. The sensor may be embedded in the soft body of the soft robotic device, attached to the soft body of the soft robotic device, or otherwise linked to the soft body of the soft robotic device.

公开(公告)号：EP3129194A4

公开(公告)日：2018-03-28

申请号：EP15776043

申请日：2015-04-13

Applicant: HARVARD COLLEGE

Inventor： MOSADEGH BOBAK ,  GERBERICH BRANDON GRANT ,  WHITESIDES GEORGE M

IPC: B25J9/00

CPC classification number: A61F2/586 ,  A61F2/5044 ,  A61F2/583 ,  A61F2/68 ,  A61F2/72 ,  A61F2002/5012 ,  A61F2002/74 ,  A61F2002/747 ,  A61F2002/748 ,  B25J15/0023 ,  B25J15/12 ,  B29C70/541 ,  B29C70/70 ,  B29C70/88 ,  B29L2031/7532

Abstract: A finger actuator, includes a plurality of fluidically interconnected inflatable chambers, wherein each chamber comprises outer walls having an embedded extensible layer selected to constrain radial expansion and freestanding inner walls; and an inextensible layer connected to the chambers at a base of the chambers, the inextensible layer comprising a flexible polymer and having an embedded inextensible layer that extends along the length of the finger actuator.

公开(公告)号：EP2764255A4

公开(公告)日：2016-07-06

申请号：EP12864130

申请日：2012-10-08

Applicant: HARVARD COLLEGE

Inventor： SHEPHERD ROBERT F ,  NUNES RUI ,  WHITESIDES GEORGE M ,  STOKES ADAM ,  FREAKE JACOB ,  MORIN STEPHEN A ,  CADEMARTIRI LUDOVICO ,  CHEN XIN

IPC: B25J9/10 ,  B25J9/14

CPC classification number: F15B13/04 ,  B25J9/1075 ,  B25J9/142

Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.

Abstract translation: 提供了一种用于提供软机器人的系统和方法。 在一个系统中，机器人装置包括具有流体室的柔性体，其中柔性体的一部分包括弹性可伸长的材料，并且柔性体的一部分相对于弹性可伸长的材料是应变限制的。 机器人装置还可以包括与流体室流体连通的加压入口，以及与加压入口流体连通的加压装置，该加压装置包括反应室，该反应室被配置成容纳产生气体的化学反应以提供加压气体 加压入口。