公开(公告)号：HU199288B

公开(公告)日：1990-02-28

申请号：HU252587

申请日：1987-06-02

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04 ,  A61K31/43

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：DK258989A

公开(公告)日：1989-11-28

申请号：DK258989

申请日：1989-05-26

Applicant: HOECHST AG

Inventor： HAENEL HEINZ ,  SCHRINNER ELMAR

IPC: C07D473/10 ,  A61K31/35 ,  A61K31/52 ,  A61K31/522 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61K31/72

Abstract: Medicines which contain a substance which liberates tumour necrosis factor (TNF) are better tolerated and can be given in higher doses when they contain a TNF inhibitor, especially a xanthine derivative.

公开(公告)号：CA1259606A

公开(公告)日：1989-09-19

申请号：CA300245

申请日：1978-03-31

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  BORMANN DIETER ,  EHLERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: A61K31/397 ,  A61K31/435 ,  A61K31/505 ,  A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B25J15/08 ,  C07D205/08 ,  C07D277/20 ,  C07D277/40 ,  C07D277/42 ,  C07D277/50 ,  C07D463/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/36 ,  C07D505/00 ,  C07D519/06 ,  C07F9/6561 ,  C07D501/46

Abstract: CEPHEM DERIVATIVES AND PROCESSES FOR THEIR MANUFACTURE of the disclosure: Cephem derivatives of the general formula in which R1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl, or alkylsulfonyl group or an amino-protec-tive group, R2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R3 denotes hydrogen, an ester group or a cation, R4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes sulfur, oxygen or -CH2- and -NH- and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group -CH2Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R2O group is in th syn-position.

公开(公告)号：PT88150A

公开(公告)日：1989-06-30

申请号：PT8815088

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  MEICHSNER CHRISTOPH ,  WINKLER IRVIN ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：DK425288D0

公开(公告)日：1988-07-29

申请号：DK425288

申请日：1988-07-29

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/725

Abstract: The preparation contains or consists of… a) at least one sulphated polysaccharide and… b) at least one xanthine derivative. The preparation is suitable for the control and prophylaxis of viral diseases, especially those caused by retroviruses.

公开(公告)号：DD257015A5

公开(公告)日：1988-06-01

申请号：DD30343687

申请日：1987-06-02

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04 ,  A61K31/43

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：AU7661887A

公开(公告)日：1988-02-11

申请号：AU7661887

申请日：1987-08-06

Applicant: HOECHST AG

Inventor： SEIBERT GERHARD ,  SCHRINNER ELMAR

IPC: A61L15/46 ,  A61L15/58 ,  A61L31/16 ,  A61K31/47 ,  A61K31/495 ,  A61L15/03 ,  A61L15/06

公开(公告)号：NO872331A

公开(公告)日：1987-12-07

申请号：NO872331

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04 ,  A61K

CPC classification number: A61K31/545 ,  A61K31/43

公开(公告)号：DK284787A

公开(公告)日：1987-12-05

申请号：DK284787

申请日：1987-06-03

Applicant: HOECHST AG

Inventor： LIMBERT MICHAEL ,  SCHRINNER ELMAR ,  SEIBERT GERHARD

IPC: A61K31/545 ,  A61P31/04

Abstract: Pharmaceutical preparation having a synergistic, antibacterial activity and containing a) a cephalosporin derivative or physiologically acceptable salts or esters thereof, and b) a penem antibiotic of the basic structure (B) or physiologically acceptable salts or esters thereof, process for manufacturing such a preparation, and its use in the treatment of bacterial infections.

公开(公告)号：PH15919A

公开(公告)日：1983-04-22

申请号：PH20973

申请日：1978-04-03

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  BORMANN DIETER ,  EHEERS EBERHARD ,  SCHRINNER ELMAR ,  HEYMES RENE

IPC: C07D279/00 ,  C07D501/00