公开(公告)号：NZ320963A

公开(公告)日：1999-08-30

申请号：NZ32096396

申请日：1996-09-27

Applicant: LILLY CO ELI ,  COR THERAPEUTICS INC

Inventor： FISHER MATTHEW J ,  JAKUBOWSKI JOSEPH A ,  MASTERS JOHN J ,  MULLANEY JEFFREY T ,  PAAL MICHAEL ,  RUHTER GERD ,  RUTERBORIES KENNETH J ,  SCARBOROUGH ROBERT M ,  SCHOTTEN THEO ,  STENZEL WOLFGANG

IPC: A61K31/00 ,  A61K31/42 ,  A61K31/423 ,  A61K31/435 ,  A61K31/437 ,  A61K31/438 ,  A61K31/535 ,  A61K31/537 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61P7/00 ,  A61P7/02 ,  C07D221/20 ,  C07D263/52 ,  C07D471/10 ,  C07D498/10 ,  C07D401/06 ,  C07D221/00

Abstract: This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, as shown by formula (I):wherein Q, L, Ai, Bj, R0, R3, R10, m, n, p and q are as defined in the disclosure, which are useful in inhibiting of platelet aggregation.

公开(公告)号：DK0639202T3

公开(公告)日：1999-08-09

申请号：DK93910827

申请日：1993-04-27

Applicant: COR THERAPEUTICS INC

Inventor： SWIFT ROBERT L ,  DU MEE CHARLES P ,  RANDOLPH ANNE E

IPC: C12N15/00 ,  A61K9/00 ,  A61K9/08 ,  A61K38/00 ,  A61K38/07 ,  A61K38/08 ,  A61K38/17 ,  A61K38/36 ,  A61K38/39 ,  A61K47/12 ,  A61P7/02 ,  C07K1/00 ,  C07K5/062 ,  C07K5/083 ,  C07K5/103 ,  C07K7/06 ,  C07K14/75 ,  C07K14/78 ,  C12P21/02 ,  A61K37/02

公开(公告)号：CA2318199A1

公开(公告)日：1999-07-22

申请号：CA2318199

申请日：1999-01-08

Applicant: COR THERAPEUTICS INC

Inventor： LAIBELMAN ALAN M ,  JANTZEN HANS-MICHAEL ,  CONLEY PAMELA B ,  FRETTO LARRY J ,  SCARBOROUGH ROBERT M

IPC: A61K31/549 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P43/00 ,  C07D513/04 ,  C07D513/14 ,  C07D519/00 ,  A61K31/54 ,  C07D277/00 ,  C07D285/00

Abstract: The invention relates to novel compounds of formula (I) containing fused heterocyclic ring systems which are effective platelet ADP receptor inhibitors. Such compounds including pharmaceutically acceptable salts are useful in various pharmaceutical compositions for the prevention and/or treatment of cardiovascular disease particularly those related to thrombosis.

公开(公告)号：CA2300478A1

公开(公告)日：1999-02-18

申请号：CA2300478

申请日：1998-08-11

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  C07K5/062 ,  C07K5/078 ,  C07K5/06 ,  A61K38/05

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders and have formula (I).

公开(公告)号：CA2299612A1

公开(公告)日：1999-02-18

申请号：CA2299612

申请日：1998-08-11

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61P7/02 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07D417/12 ,  A61K31/5513 ,  A61K31/69 ,  A61P9/10 ,  C07D243/14 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07F5/02

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. They have structure (I), where the meanings of the substituents are as indicated in the text.

公开(公告)号：AU8274498A

公开(公告)日：1999-01-25

申请号：AU8274498

申请日：1998-07-01

Applicant: COR THERAPEUTICS INC

Inventor： TOMLINSON JAMES A

IPC: C12N15/09 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/88 ,  C12N15/60 ,  C12N15/85

公开(公告)号：CA2294381A1

公开(公告)日：1999-01-14

申请号：CA2294381

申请日：1998-07-01

Applicant: COR THERAPEUTICS INC

Inventor： TOMLINSON JAMES E

IPC: C12N15/09 ,  C12N5/10 ,  C12N9/88 ,  C12N15/60 ,  C12R1/91 ,  C12N15/85

Abstract: A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described.

公开(公告)号：AU700964B2

公开(公告)日：1999-01-14

申请号：AU4156196

申请日：1995-11-09

Applicant: COR THERAPEUTICS INC

Inventor： GIESE NEILL A ,  LOKKER NATHALIE ,  LAIBELMAN ALAN M ,  SCARBOROUGH ROBERT M

IPC: C07D231/38 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/455 ,  A61P43/00 ,  C07D231/40 ,  C07D401/06 ,  C07D405/04 ,  C07D409/06

Abstract: A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of the formula: wherein: R1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R3 is H or lower alkyl; R5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R6 is H or lower hydrocarboyl.

公开(公告)号：AU6896398A

公开(公告)日：1998-11-11

申请号：AU6896398

申请日：1998-04-13

Applicant: COR THERAPEUTICS INC

Inventor： SU TING ,  ZHU BING-YAN ,  SCARBOROUGH ROBERT M JR

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07K5/065 ,  C07K5/068 ,  C07K5/078 ,  C07K5/087 ,  C07K5/09 ,  C07K5/06 ,  A61K38/05

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：MX9709910A

公开(公告)日：1998-07-31

申请号：MX9709910

申请日：1997-12-08

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  LAIBELMAN ALAN M ,  SINHA UMA ,  ZHU BING-YAN

IPC: A61P7/02 ,  C07C279/24 ,  A61K38/00 ,  C07C281/06 ,  C07C309/30 ,  C07C335/38 ,  C07K5/06 ,  C07K5/068 ,  C07K5/072 ,  C07K5/08 ,  C07K05/06 ,  A61K38/55

Abstract: Se describen compuestos novedosos, sus sales y composiciones relacionadas con los mismos que tienen actividad contra el factor Xa de mamífero; los compuestos son utiles in vitro o in vivo para prevenir o tratar trastornos de coagulacion.