Flat-Plate Focusing Ultrasonic Transducer and Acoustic Lens Which are Composed of Annular Array Piezoelectric Element, and Methods of Manufacturing and Designing Thereof

    公开(公告)号:US20220241818A1

    公开(公告)日:2022-08-04

    申请号:US17325669

    申请日:2021-05-20

    Abstract: The present invention relates to a flat-plate focusing ultrasonic transducer and an acoustic lens composed of an annular array piezoelectric element and methods of manufacturing and designing thereof, more particularly to a flat-plate focusing ultrasonic transducer composed of an annular array piezoelectric element, wherein the annular array piezoelectric element has a plurality of concentric regions which is concentrically arranged in a concentric circle shape with respect to a center point, the concentric region has ring shaped sound insulation regions and piezoelectric regions which are alternatively formed in a direction from the center point to a radius direction, so as to focus a sound wave near a focal point, wherein the piezoelectric regions are composed of a piezoelectric ring that is composed of a piezoelectric material and thus excites a sound wave, the concentric region is in a shape of a flat-plate of which both sides are flat and which has a constant thickness, and each radius of the plurality of the sound insulation regions and the piezoelectric regions in the concentric region are calculated based on a set focal length of the ultrasonic transducer and a frequency of a set sound wave.

    METHOD FOR MEASURING ORGANIC MATTER IN BLOOD BY USING LDI-MS, AND DEVICE THEREFOR

    公开(公告)号:US20220084804A1

    公开(公告)日:2022-03-17

    申请号:US17426573

    申请日:2019-12-30

    Abstract: A method for detecting organic matter in the blood by using LDI-MS, and a device therefor, according to the present invention, are not complicated when performing measurement and do not require the passage of many steps, and facilitate, in real time, measurement and result collection through rapid analysis. In addition, the present invention enables precise analysis even at a lower sample concentration so as to have excellent sensitivity and accuracy, enables the detection of various types of organic matter at the same time and has high throughput, and enables the structure analysis of organic matter, having undergone metabolic processes in the blood, and quantitative analysis thereof to be accurately performed without interference from a matrix.

    Method for High-Sensitivity and High-Specificity Detection of Biomolecules by Using Mass Spectrometry

    公开(公告)号:US20210318304A1

    公开(公告)日:2021-10-14

    申请号:US17271699

    申请日:2018-09-03

    Abstract: The present invention relates to a method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry and, more specifically, to a method for high-sensitivity and high-specificity detection of proteins such as miRNA or antigens by using time-of-flight secondary ion mass spectrometry (ToF-SIMS), matrix-assisted laser desorption/ionization (MALDI), or laser desorption/ionization (LDI) mass spectrometry. The method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry, according to the present invention, enables high-sensitivity and high-specificity detection of biomolecules by using surface mass spectrometry, and the method is expected to be used for the diagnosis and prediction of diseases by quantifying, from a biosample, a target probe such as miRNA which is known as a disease marker.

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