公开(公告)号：AU2009269127A1

公开(公告)日：2010-01-14

申请号：AU2009269127

申请日：2009-08-06

Applicant: ACADEMIA SINICA

Inventor： YU ALICE ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.

公开(公告)号：AU2025201644A1

公开(公告)日：2025-03-27

申请号：AU2025201644

申请日：2025-03-06

Applicant: ACADEMIA SINICA

Inventor： LIAO HSIN-YU ,  WANG SHIH-CHI ,  KO YI-AN ,  LIN KUO-I ,  MA CHE ,  CHENG TING-JEN ,  WONG CHI-HUEY

IPC: A61K39/145 ,  A61P31/16 ,  C12N7/04

Abstract: Abstract The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of HI subtype HA (HI HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequences, each having at least 60% homology with a globular head domain consensus sequence of HI subtype HA (HI HA) or H5 subtype HA (H5 HA).

公开(公告)号：CA2870335C

公开(公告)日：2022-05-03

申请号：CA2870335

申请日：2013-04-12

Applicant: ACADEMIA SINICA ,  WONG CHI HUEY ,  FANG JIM MIN ,  LIU KUNG CHENG ,  JAN JIA TSRONG ,  CHENG YIH SHYUN E ,  CHENG TING JEN R

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  LIU KUNG-CHENG ,  JAN JIA-TSRONG ,  CHENG YIH-SHYUN E ,  CHENG TING-JEN R

IPC: C07D309/28 ,  A61K31/195 ,  A61K31/215 ,  A61K31/351 ,  A61K31/662 ,  A61P29/00 ,  A61P31/16 ,  C07C229/64 ,  C07C279/16 ,  C07D407/12 ,  C07F9/655

Abstract: Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti- influenza conjugate drugs are provided. The synthetic bifunctional ZA conjugates act synergistically towards protection of mice lethally infected by H1N1 or H5N1 influenza viruses. The efficacy of ZA-7-CA, ZA-7-CA-amide and ZA-7-Nap conjugates is much greater than the combination therapy of ZA with anti-inflammatory agents.

公开(公告)号：AU2015267051B2

公开(公告)日：2022-03-17

申请号：AU2015267051

申请日：2015-05-27

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  TSAI TSUNG-I

IPC: C12N9/24

Abstract: The present disclosure relates to an a-fucosidase having a-(1,2), a-(1,3), a-(1,4), and a-(1,6) fucosidase activity. The present disclosure also relates to the compositions comprising the α-fucosidase, and the methods of producing and using the α-fucosidase in cleaving a-(1,2), a-(1,3), a-(1,4), and/or a-(1,6)-linked fucoses in the glycoconjugates. Accordingly, the present invention provides the compositions and methods for the improved enzymatic hydrolysis of fucose in vitro. In particular, the present invention is useful for the efficient cleavage of core fucose in native glycoproteins without denaturation or functional deterioration of glycoproteins. The compositions and methods of the invention can facilitate the Fc glycoengineering of Fc fusion proteins or antibodies, such as therapeutic antibodies.

公开(公告)号：CA2854619C

公开(公告)日：2022-02-01

申请号：CA2854619

申请日：2011-11-04

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  TSENG YUNG-CHIEH

IPC: C12N7/00 ,  C07K14/11 ,  C12N7/02 ,  C12N15/09 ,  C12P21/02

Abstract: Methods for production of virus particles with simplified glycosylation on structural or surface proteins are provided. When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles are disclosed. An exemplary disclosure of influenza viruses and methods for production of mono-glycosylated influenza virus particles is provided. Methods for production of mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1) are provided.

公开(公告)号：DK3250590T3

公开(公告)日：2021-10-18

申请号：DK16744256

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  MA CHE ,  WU HAN-CHUNG ,  WU CHUNG-YI

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12P19/14

公开(公告)号：AU2016211176B2

公开(公告)日：2021-01-28

申请号：AU2016211176

申请日：2016-01-30

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  MA CHE ,  WU HAN-CHUNG

IPC: C07K16/00 ,  A61K39/42 ,  C07K16/10 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

Abstract: The present disclosure relates to compositions and methods of use comprising antibodies or binding fragments thereof further comprising universal Fc glycoforms.

公开(公告)号：CA3131096A1

公开(公告)日：2020-10-08

申请号：CA3131096

申请日：2020-03-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  LO HONG-JAY

IPC: C07H3/02 ,  C07K16/30

Abstract: Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to ?2,6-linked 3-fluoro-sialoside terminated N-glycans, and treatment of cancer with such monoclonal antibodies.

公开(公告)号：AU2019203313B2

公开(公告)日：2020-04-30

申请号：AU2019203313

申请日：2019-05-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：AU2018200094B2

公开(公告)日：2019-02-14

申请号：AU2018200094

申请日：2018-01-05

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/04 ,  C12N9/10

Abstract: Abstract A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.