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    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION
    141.
    发明专利
    MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 未知

    公开(公告)号：SG169918A1

    公开(公告)日：2011-04-29

    申请号：SG2009066242

    申请日：2009-10-02

    Applicant: FLUIDIGM CORP

    Inventor： COHEN DAVID ,  MAY ANDREW ,  PIEPRZYK MARTIN ,  FOWLER BRIAN ,  LEE KIM HUAT ,  YAN JUN ,  ZHOU MING FANG ,  NG SENG BENG

    Abstract: The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader. Fig. 1B

    MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS
    143.
    发明专利
    MULTI-PRIMER AMPLIFICATION METHOD FOR BARCODING OF TARGET NUCLEIC ACIDS 未知

    公开(公告)号：CA2757560A1

    公开(公告)日：2010-10-07

    申请号：CA2757560

    申请日：2010-04-02

    Applicant: FLUIDIGM CORP

    Inventor： MAY ANDREW ,  CHEN PEILIN ,  WANG JUN ,  KAPER FIONA ,  ANDERSON MEGAN

    IPC: C12Q1/68 ,  B81B7/04 ,  C12M1/36 ,  C12P19/34 ,  C40B20/04 ,  C40B30/04 ,  C40B70/00 ,  G01N33/50

    Abstract: In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences. In other embodiments, the present invention provides a microfluidic device that includes a plurality of first input lines and a plurality of second input lines. The microfluidic device also includes a plurality of sets of first chambers and a plurality of sets of second chambers. Each set of first chambers is in fluid communication with one of the plurality of first input lines. Each set of second chambers is in fluid communication with one of the plurality of second input lines. The microfluidic device further includes a plurality of first pump elements in fluid communication with a first portion of the plurality of second input lines and a plurality of second pump elements in fluid communication with a second portion of the plurality of second input lines.

    DISPOSITIVOS FORMADORES DE CRISTAL Y SISTEMAS Y METODOS PARA HACER Y UTILIZAR LOS MISMOS.
    144.
    发明专利
    DISPOSITIVOS FORMADORES DE CRISTAL Y SISTEMAS Y METODOS PARA HACER Y UTILIZAR LOS MISMOS. 未知

    公开(公告)号：MXPA06008399A

    公开(公告)日：2008-03-07

    申请号：MXPA06008399

    申请日：2005-01-25

    Applicant: FLUIDIGM CORP

    Inventor： GROSSMAN ROBERT ,  UNGER MARC ,  LAM PHILLIP ,  CHOU HOU-PU ,  KIMBALL JAKE ,  PIERPRZYK MARTIN

    IPC: G01N33/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    Abstract: La presente invencion proporciona dispositivos de microfluido y metodos para su uso. La invencion ademas proporciona aparatos y sistemas para usar los dispositivos de microfluido, analizar reacciones realizadas en los dispositivos de microfluido, y sistemas para generar, almacenar, organizar, y analizar datos generados del uso de los dispositivos de microfluido. La invencion ademas proporciona metodos para usar y hacer sistemas y dispositivos de microfluido que, en algunas modalidades, son utiles para la formacion de cristal. En una modalidad, un aparato incluye una platina que tiene una cara de platina con uno o mas puertos de fluido en la misma. Los puertos de fluido espacialmente corresponden a uno o mas pozos sobre una superficie del dispositivo de microfluido. Se incluye una plataforma para sostener el dispositivo de microfluido con relacion a la platina, y un accionador de platina para empujar la platina contra el dispositivo de microfluido de manera que por lo menos uno de los puertos de fluido de la platina es empujado contra uno de los pozos para formar una camara de presion que comprende el pozo y el puerto, de manera que ciando se introduce o remueve fluido presurizado hacia o desde la camara de presion a traves de uno de los puertos, la presion de fluido es cambiada ahi.

    Microfluidic devices and methods of using same
    148.
    发明专利
    Microfluidic devices and methods of using same 未知

    公开(公告)号：AU2004228678A1

    公开(公告)日：2004-10-21

    申请号：AU2004228678

    申请日：2004-04-05

    Applicant: FLUIDIGM CORP

    Inventor： UNGER MARC ,  MCBRIDE LINCOLN ,  FACER GEOFFREY ,  LUCERO MICHAEL ,  NASSEF HANY RAMEZ

    IPC: B01L3/00 ,  B01L3/02 ,  B01L7/00 ,  B01L99/00 ,  B81B20060101 ,  C12Q1/68 ,  G01N1/10

    Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

    A microfluidic design automation method and system
    149.
    发明专利
    A microfluidic design automation method and system 未知

    公开(公告)号：AU7305701A

    公开(公告)日：2002-01-08

    申请号：AU7305701

    申请日：2001-06-27

    Applicant: FLUIDIGM CORP

    Inventor： LEE MICHAEL ,  WORTHINGTON GAJUS ,  HARRIS GREGORY ,  MONTGOMERY JAMES

    IPC: B01F13/00 ,  B01F15/00 ,  B01L3/00 ,  B81B1/00 ,  B81C99/00 ,  G06F17/50

    Abstract: The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is provided. The method includes developing synthesizable computer code for a design. Next, a microfluidic circuit schematic, including a plurality of symbols for microfluidic components, is generated either interactively or using the synthesizable computer code. The microfluidic circuit schematic is then functionally simulated. The microfluidic components are placed and routed on a template to form a physical layout. Then the physical layout is physically simulated using dynamic simulation models of the microfluidic components; and the physical layout is written to a layout file.

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