公开(公告)号：AU4235697A

公开(公告)日：1998-04-02

申请号：AU4235697

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：AU686047B2

公开(公告)日：1998-01-29

申请号：AU4819596

申请日：1996-03-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61K49/22

公开(公告)号：DK0531421T3

公开(公告)日：1998-01-12

申请号：DK91910712

申请日：1991-05-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K49/00 ,  A61K49/22 ,  A61K31/70 ,  A61K31/695 ,  A61K31/715 ,  A61K31/73

公开(公告)号：CA2256592A1

公开(公告)日：1997-12-24

申请号：CA2256592

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  RAMASWAMI VARADA RAJAN ,  FRITZ THOMAS A ,  MATSUNAGA TERRY O

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61K9/127 ,  A61B8/13 ,  A61M5/14

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：AU684088B2

公开(公告)日：1997-12-04

申请号：AU7094894

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K31/70 ,  A61K39/395 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00

公开(公告)号：AR001496A1

公开(公告)日：1997-10-22

申请号：AR33601096

申请日：1996-04-02

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K9/14

Abstract: Composición que comprenden, en un vehículo acuoso, un lípido y un material que es capaz de estabilizar la composición. El material estabilizante estáasociado en forma no covalente con dicho lípido y está presente en una cantidad suficientepara recubrir el lípido pero insuficiente para aumentar laviscosidad de la composición. Las composiciones son particularmente adecuadas para el uso en aplicaciones de diagnóstico, incluyendo ultrasonido. Lascomposiciones pueden tomar la forma deco mposiciones vesiculares, tales como micelas y liposomas.

公开(公告)号：AU6270396A

公开(公告)日：1996-12-30

申请号：AU6270396

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  SHEN DEKANG ,  WU GUANLI

IPC: A61K47/48 ,  A61K45/00 ,  A61K49/00 ,  A61K49/22 ,  C08F220/44 ,  C08G65/32 ,  A61B5/055 ,  A61K49/04

公开(公告)号：AU5936096A

公开(公告)日：1996-12-24

申请号：AU5936096

申请日：1996-05-28

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K47/24 ,  A61K9/127 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61B8/13 ,  C07D265/30

Abstract: Stabilized compositions comprising, in combination with a gas, a fluorinated amphiphilic compound. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

公开(公告)号：CA2217494A1

公开(公告)日：1996-10-10

申请号：CA2217494

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61B8/13 ,  A61K9/10 ,  A61K47/44

Abstract: Compositions comprising, in an aqueous carrier, a lipid and a material which is capable of stabilizing the composition. The stabilizing material is associated non-covalently with said lipid and is present in an amount sufficient to coat the lipid but insufficient to raise the viscosity of the composition. The compositions are particularly suitable for use in diagnostic applications, including ultrasound. The compositions can take the form of vesicular compositions, such as micelles and liposomes.

公开(公告)号：AU2645495A

公开(公告)日：1995-12-18

申请号：AU2645495

申请日：1995-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/107 ,  A61K9/50 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  B01J13/00

Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.