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公开(公告)号：KR100374482B1
公开(公告)日：2003-03-03
申请号：KR1020020005448
申请日：2002-01-30
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/5123 , A61K9/1075 , A61K9/1272 , A61K48/00 , C12N15/88
Abstract: The present invention relates to oil-in-water lipid emulsions composed of non-triglyceride oils and solid lipid nanoparticles (SLN) composed of triglyceride or ethyl stearate used as gene transfection agents and drug delivery systems and method for preparing thereof. The present invention also concerns the method of transferring genes or drugs efficiently into cells by using the lipid emulsions and solid lipid nanoparticles. Also the present invention relates to the method of preparing lipid emulsions containing lipophilic or amphiphilic drugs by using squalene or squalane as the core-oil. The present invention also concerns the method of preparing the solid lipid nanoparticles containing lipophilic or amphiphilic drugs by using ethyl stearate as the core-fat.
Abstract translation: 本发明涉及由非甘油三酯油和由甘油三酯或硬脂酸乙酯组成的固体脂质纳米粒（SLN）组成的水包油脂质乳剂，其用作基因转染剂和药物递送系统及其制备方法。 本发明还涉及通过使用脂质乳剂和固体脂质纳米粒子将基因或药物有效地转移到细胞中的方法。 本发明还涉及通过使用角鲨烯或角鲨烷作为核心油来制备含有亲脂性或两亲性药物的脂质乳剂的方法。 本发明还涉及通过使用硬脂酸乙酯作为核心脂肪来制备含有亲脂性或两亲性药物的固体脂质纳米粒子的方法。
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公开(公告)号：KR1020020066778A
公开(公告)日：2002-08-21
申请号：KR1020010007125
申请日：2001-02-13
Applicant: 한국과학기술연구원
IPC: A61K47/44
CPC classification number: A61K9/0014 , A61K9/0019 , A61K47/44
Abstract: PURPOSE: A process of preparing the subject liquid or powder formulation is provided by adding an aqueous solution of poorly absorbable material in the body such as peptide, protein or water-soluble polymer to a mixture of monoglyceride, emulsifiers and organic solvents. Whereby, the formulation can be easily dispersed without addition of mechanical force and does not generate phase separation, hydrolysis and oxidation even when stored for long period time. CONSTITUTION: A composition to promote absorption of a poorly absorbable material in body comprises 9 to 90% by weight of one or more monoglycerides, 0.01 to 90% by weight of one or more emulsifiers, 0.01 to 10% by weight of an aqueous solution having solubility to a poorly absorbable material in body, 0 to 90.9% by weight of an organic solvent and 0 to 5% by weight of an additive. Also it is prepared by dissolving the monoglycerides and emulsifiers in the organic solvent containing the aqueous solution having solubility to a poorly absorbable material in body and removing a volatile organic solvent from the obtained viscose composition. The formulation contains 1 to 99% by weight of the composition and 1 to 99% by weight of an organic solvent.
Abstract translation: 目的：制备本发明液体或粉末制剂的方法是通过将不良吸收材料的水溶液（例如肽，蛋白质或水溶性聚合物）加入到单酸甘油酯，乳化剂和有机溶剂的混合物中来提供的。 因此，即使长期储存，配方也可以容易地分散而不增加机械力，并且不会产生相分离，水解和氧化。 构成：促进吸收体内吸收不良物质的组合物包含9至90重量％的一种或多种甘油单酯，0.01至90重量％的一种或多种乳化剂，0.01至10重量％的含有 对体内难以吸收的材料的溶解度，0-90.9重量％的有机溶剂和0-5重量％的添加剂。 另外，通过将单酸甘油酯和乳化剂溶解在含有对体内吸收不良的材料具有溶解性的水溶液的有机溶剂中，并从得到的粘胶组合物中除去挥发性有机溶剂。 该制剂含有1至99重量％的组合物和1至99重量％的有机溶剂。
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公开(公告)号：KR1020020033665A
公开(公告)日：2002-05-07
申请号：KR1020020005448
申请日：2002-01-30
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/5123 , A61K9/1075 , A61K9/1272 , A61K48/00 , C12N15/88
Abstract: PURPOSE: Provided are a solid lipid nanoparticle as a gene or drug carrier, a formulation, and a method for preparing the same, thereby effectively transferring DNAs, bioprobes and drugs to the target cells. CONSTITUTION: The solid lipid nanoparticle comprises: a) at least one solid lipid nanoparticle material selected from C12-18 triglyceride or ethyl stearate, 2-30%; b) at least one kind of emulsifier including cationic surfactants, 0.01-20%; and c) the balance of water.
Abstract translation: 目的：提供作为基因或药物载体的固体脂质纳米颗粒，制剂及其制备方法，从而有效地将DNA，生物探针和药物转移至靶细胞。 构成：固体脂质纳米颗粒包含：a）至少一种选自C12-18甘油三酸酯或硬脂酸乙酯的固体脂质纳米颗粒材料，2-30％; b）至少一种乳化剂，包括阳离子表面活性剂，0.01-20％; 和c）水的平衡。
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公开(公告)号：KR1020010003853A
公开(公告)日：2001-01-15
申请号：KR1019990024336
申请日：1999-06-25
Applicant: 한국과학기술연구원
CPC classification number: A61K47/36 , A61K9/1652 , A61K39/092
Abstract: PURPOSE: An arginate-microsphere used for oral vaccine is provided, which delivers antigens effectively through a pathway by Peyer's patch and a by-pathway of lymphatic gland with its small size; shows higher immunity property; improves level of serum and mucous membrane when administrated with cholera toxin or cholera toxin B unit; so can be used as an effective oral vaccine. CONSTITUTION: A process for the preparation of arginate-microsphere used for oral vaccine comprises: adding a solution containing antigen protein(or antigen protein and immuno-adjuvant) to arginate solution; adding n-octanol solution containing an emulsifier to the antigen protein(or antigen protein and immuno-adjuvant)-arginate mixed solution, and homogenizing; adding calcium chloride-contained n-octanol using a sprayer while stirring the emulsion slowly; adding calcium chloride solution to saturate the emulsion, and gelating microspheres; dehydrating the microspheres by adding dehydration solvent; filtering the microspheres, washing with alcohol, and drying in vacuum state.
Abstract translation: 目的：提供用于口服疫苗的精氨酸 - 微球，通过派耶氏贴片和小尺寸的淋巴管旁路有效传递抗原; 显示较高的免疫力; 当施用霍乱毒素或霍乱毒素B单位时，提高血清和粘膜水平; 所以可以用作有效的口服疫苗。 构成：用于制备用于口服疫苗的精氨酸 - 微球的方法包括：向精氨酸溶液中加入含有抗原蛋白（或抗原蛋白和免疫佐剂）的溶液; 向抗原蛋白（或抗原蛋白和免疫佐剂）中加入含有乳化剂的正辛醇溶液 - 调节混合溶液，均化; 使用喷雾器在缓慢搅拌乳状液的同时加入含氯化钙的正辛醇; 加入氯化钙溶液使乳液饱和，凝胶化微球; 加入脱水溶剂使微球脱水; 过滤微球，用乙醇洗涤，并在真空状态下干燥。
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公开(公告)号：KR1019980067138A
公开(公告)日：1998-10-15
申请号：KR1019970003022
申请日：1997-01-31
Applicant: 한국과학기술연구원
IPC: A61K9/107
Abstract: 본 발명은 세포내로 유전자 DNA 및 생물학적 활성 약물을 전달할 수 있는 지방 유제 및 그것의 제조방법에 관한 것이다. 또한 본 발명은 지방 유제를 사용하여 세포내로 DNA와 같은 생물학적 활성 약물을 효과적으로 전달하는 방법에 관한 것이다. 본 발명의 지방 유제는 세포내로 유전자를 효과적으로 전달할 수 있고, 특히 혈청 중에서 높은 안정성 및 유전자 전달 효율을 나타냄으로써 임상에서 유전자 치료에 적합한 약물 전달 체계가 될 수 있다.
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Patent Agency Ranking
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公开(公告)号：KR1019970032848A
公开(公告)日：1997-07-22
申请号：KR1019950050632
申请日：1995-12-15
Applicant: 한국과학기술연구원
Abstract: 본 발명은 알긴산염으로 이루어진, 입자 직경이 나노미터 내지 수 마이크로미터인 알긴산염 초미세구립자 및 그의 제조방법을 제공한다. 본 발명의 알긴산염 초미세구립자의 제조방법은 알긴산염 수용액을 계면활성제가 첨가된 유기용매에 분산, 교반시켜 에멀젼을 만든 다음, 칼슘 용액을 이 에멀젼에 첨가하여 겔화하고, 탈수 용매를 가해 탈수시키고 경화시키는 것으로 이루어진다. 본 발명의 알긴산염 초미세구립자는 비경구 투여에 의한 약물의 표적 지향, 펩타이드 약물의 경구 흡수, 또는 경구용 백신 개발등 폭넓게 응용될 수 있다.
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公开(公告)号：KR101930399B1
公开(公告)日：2018-12-18
申请号：KR1020170121169
申请日：2017-09-20
Applicant: 한국과학기술연구원
IPC: A61K47/66 , A61K47/69 , A61K47/64 , A61K31/704
Abstract: 본 발명에 따른 약물복합체는 종양조직에서 특이적으로 발현하는 카텝신 B 효소에 의해 분해되어, 독소루비신을 방출하는 프로드러그(prodrug)로, 자가조립형 나노입자 생성이 가능하며, 종양세포에 특이적으로 반응하여 활성화되기 때문에, 암 예방 또는 치료과정에서 유도되는 심각한 세포 손상 및 사망 등의 부작용을 해결할 수 있다는 장점을 갖는다.
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