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    PROCESS FOR OBTAINING ANTIBODIES
    155.
    发明专利
    PROCESS FOR OBTAINING ANTIBODIES 未知

    公开(公告)号：SG10201408639RA

    公开(公告)日：2015-02-27

    申请号：SG10201408639R

    申请日：2011-02-02

    Applicant: UCB PHARMA SA

    Inventor： BILGISCHER JEAN-PASCAL PIERRE ,  BASSETT PHILIP JONATHAN ,  PEARCE-HIGGINS MARK ROBERT ,  KENNY ANDREW JOHN

    Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.

    FORMULACION FARMACEUTICA
    157.
    发明专利
    FORMULACION FARMACEUTICA 未知

    公开(公告)号：PE20150190A1

    公开(公告)日：2015-02-13

    申请号：PE2014002385

    申请日：2013-06-20

    Applicant: UCB PHARMA SA

    Inventor： YATES ANDREW JEFFREY ,  CLIPSTONE JAMES GREGORY

    IPC: C07K16/28

    Abstract: LA PRESENTE INVENCION SE REFIERE A METODOS Y MEDIOS PARA REDUCIR LA VISCOSIDAD DE UNA FORMULACION FARMACEUTICA QUE COMPRENDE UN ANTICUERPO U OTRA PROTEINA TERAPEUTICA A UNA ELEVADA CONCENTRACION. LA PRESENTE INVENCION PROPORCIONA UNA FORMULACION FARMACEUTICA LIQUIDA QUE COMPRENDE UN ANTICUERPO A CONCENTRACION ELEVADA CON UNA VISCOSIDAD REDUCIDA QUE NO IMPIDE SU PROCESAMIENTO NI LA INYECCION DE LA FORMULACION FARMACEUTICA. EL ANTICUERPO ES EPRATUZUMAB A UNA CONCENTRACION DE 200 A 400 MG/ML

    Recombinant bacterial host cell for protein expression
    160.
    发明专利
    Recombinant bacterial host cell for protein expression 未知

    公开(公告)号：IL235041D0

    公开(公告)日：2014-12-31

    申请号：IL23504114

    申请日：2014-10-07

    Applicant: UCB PHARMA SA

    IPC: C07K20060101

    Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti FcRn antibodies and proteins made by the methods described herein.

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