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公开(公告)号：CO4700526A1
公开(公告)日：1998-12-29
申请号：CO96029749
申请日：1996-06-07
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Péptidos novedosos de la fórmula I:R1 R2 N-CHX-CO-A-B-D-E-(F)t-K en donde R1 es metilo, etilo o isopropilo; R2 es hidrógeno, metilo o etileno; R1 -N-R2 juntos pueden ser un anillo de pirrolidina; A es un residuo de valil, isoleucil, leucil, 2-tert-butilglicil, 2-etilglicil-norleucil o norvalil; B es un residuo de N-metil-valil, -leucil, -isoleucil, norvalil, norleucil, 2-tert-butilglicil, -3-tert-butilalamil, o 2-etilglicil; D es un residuo 3,4-de hidroprolil, 4-fluoroprolil, 4,4-difluoroprolil,azetidina-2-carbonil, 3-metilprolil, 4-metilprolil, o 5-metilpropil; E es un residuo propil, homopropil, hidroxipropil o tiazolidina-4-carbonil;F es un residuo de valil, 2-tert-butilglicil-isoleucil, leucil 2-ciclohexilglicil, norleucil, norvalil, neopentilglicil, alanil, ß-alanil o aminoisobutiroil;X es alkilo (preferiblemente C2-5 ), ciclopropil, o ciclopentilo; t es 0 ó 1; yK es alkoxi (Preferiblemente C1-4 ), benxiloxi o una traza amino substituida o no substituida;y las sales de los mismos con ácido tolerados fisiológicamente.
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公开(公告)号：TR9801102T2
公开(公告)日：1998-12-21
申请号：TR9801102
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
CPC classification number: A61K38/08
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公开(公告)号：TR199801102T2
公开(公告)日：1998-12-21
申请号：TR9801102
申请日：1996-12-11
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：DK0642530T3
公开(公告)日：1998-10-26
申请号：DK93909931
申请日：1993-05-10
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA
IPC: A61K38/00 , A61K38/08 , A61P35/00 , A61P35/02 , C07K5/062 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , C07K7/06 , A61K37/02 , A61K38/04
Abstract: Novel derivates of dolastatin of formula (I) in which R , R , A, B, D, E, F, G, K, X, t, u, v, and w have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：MX9803662A
公开(公告)日：1998-09-30
申请号：MX9803662
申请日：1998-05-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MULLER STEFAN , ZIERKE THOMAS
Abstract: La presente invencion se refiere a los péptidos novedosos de la formula: A-B-D-E-F-L, en donde A, B, D, E, F y L tienen los significados mencionados en la especificacion, y su preparacion. Los compuestos novedosos son adecuados para controlar enfermedades.
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Patent Agency Ranking156.发明专利
公开(公告)号：AU6448298A
公开(公告)日：1998-09-29
申请号：AU6448298
申请日：1998-03-05
Applicant: BASF AG , BASF BIORESEARCH CORP
Inventor： RITTER KURT , AMBERG WILHELM , BARLOZZARI TERESA , HAUPT ANDREAS , JANSSEN BERND , KLING ANDREAS
Abstract: The present invention relates to novel peptides useful as anti-cancer agents. The compounds of the invention are of Formula I,A-B-D-E-F-G(I)A, B, D, and E are alpha -amino acid residues. In one embodiment, F is an azacycloalkanecarboxylic acid residue. In this embodiment, G is a monovalent radical, for example, a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group. In another embodiment, F is an azacycloalkyl group and G is a heteroaryl group connected to F by a carbon-carbon bond. In another embodiment, the invention includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.
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公开(公告)号：CZ9801391A3
公开(公告)日：1998-09-16
申请号：CZ139198
申请日：1996-10-30
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MULLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , DE ARRUDA MONIKA , ROBINSON SIMON
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公开(公告)号：ZA9610510B
公开(公告)日：1998-06-15
申请号：ZA9610510
申请日：1996-12-13
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：NO982711L
公开(公告)日：1998-06-12
申请号：NO982711
申请日：1998-06-12
Applicant: BASF AG
Inventor： AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN J RGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：ZA9609402B
公开(公告)日：1998-05-08
申请号：ZA9609402
申请日：1996-11-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
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