公开(公告)号：AU3279378A

公开(公告)日：1979-08-02

申请号：AU3279378

申请日：1978-01-27

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  OHNSORGE ULRICH ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS DIETER

IPC: A61K31/428 ,  C07D275/04 ,  C07D401/12 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/45 ,  A61K31/55

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：NO780388L

公开(公告)日：1978-08-08

申请号：NO780388

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  OHNSORGE ULRICH ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS DIETER

IPC: A61K31/428 ,  C07D275/04 ,  C07D

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：CA1337991C

公开(公告)日：1996-01-23

申请号：CA554039

申请日：1987-12-10

Applicant: BASF AG

Inventor： SEITZ WERNER ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  RUEBSAMEN KLAUS ,  GRIES JOSEF

IPC: A61K31/275 ,  A61K31/335 ,  A61K31/357 ,  A61K31/36 ,  A61P1/04 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P43/00 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/33 ,  C07C255/35 ,  C07C255/37 ,  C07C255/42 ,  C07C255/53 ,  C07C255/58 ,  C07D317/50 ,  C07D317/60 ,  C07D319/08 ,  C07D319/18 ,  C07D321/00

Abstract: Disclosed are basically substituted phenylacetonitriles where R1, R2 and R3 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl, nitro or C1-C4-alkoxy, and two radicals in adjacent positions may furthermore together form a methylenedioxy, ethylenedioxy, 1,3-dioxatetramethylene, propylene or butylene group, R4 is a saturated or unsaturated alkyl or cycloalkyl group of not more than 8 carbon atoms or phenyl, R5 is hydrogen or C1-C4-alkyl, R6 is a saturated or unsaturated hydrocarbon radical of 6 to 15 carbon atoms which may contain a ring, and n is 2, 3 or 4. These compounds are useful for the treatment of disorders, such as cardiovascular disorders, in particular coronary heart disease, vasospasms, cerebral ischemia, hypertension and circulatory shock. They can also be used for the prophylaxis and therapy of gastric and duodenal ulcers and asthmatic disorders.

公开(公告)号：MX9203497A

公开(公告)日：1992-08-01

申请号：MX9203497

申请日：1992-06-26

Applicant: BASF AG

Inventor： SEITZ WARNER ,  UNGER LILIANE ,  RASCHACK MANFRED ,  BALDINGER VERENA ,  RUEBSMEN KLAUS ,  GRIES JOSEF

IPC: C07C255/25

公开(公告)号：CA1268471A

公开(公告)日：1990-05-01

申请号：CA524528

申请日：1986-12-04

Applicant: BASF AG

Inventor： SEITZ WERNER ,  BALDINGER VERENA ,  GRIES JOSEF ,  LENKE DIETER ,  RASCHACK MANFRED ,  RUEBSAMEN KLAUS

IPC: A61K31/135 ,  A61P1/04 ,  A61P9/00 ,  A61P9/12 ,  C07C223/02 ,  C07D317/58 ,  C07D319/18 ,  C07D325/00 ,  C07C95/08

Abstract: Phenylacetaldehydes which are substituted by basic groups, of the formula: where R1 to R8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the circulatory disorders, including cardiac diseases, high blood pressure, disturbances of blood flow and in the treatment of gastric and duodenal ulcers.

公开(公告)号：NO162557B

公开(公告)日：1989-10-09

申请号：NO852793

申请日：1985-07-11

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10

Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.

公开(公告)号：NO160258C

公开(公告)日：1989-03-29

申请号：NO823682

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22

公开(公告)号：CA1248947A

公开(公告)日：1989-01-17

申请号：CA486618

申请日：1985-07-10

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10 ,  C07D403/02

Abstract: Novel pyrrol-1-ylphenyldi-hydropyridazinones of the formula I. their preparation and their use in the treatment of disorders.

公开(公告)号：FI76550C

公开(公告)日：1988-11-10

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

公开(公告)号：FI76550B

公开(公告)日：1988-07-29

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78