-
公开(公告)号：EP2411049A4
公开(公告)日：2013-12-04
申请号：EP10756977
申请日：2010-03-26
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , MA CHE , WANG CHENG-CHI , CHEN JUINE-RUEY
IPC: A61K39/12 , A61K39/145
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/55505 , C07K16/1018 , C07K2317/76 , C12N7/00 , C12N2740/11034 , C12N2740/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2770/24134
Abstract: Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.
-
172.发明公开
公开(公告)号：EP2144594A4
公开(公告)日：2012-12-05
申请号：EP08745801
申请日：2008-04-14
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , YU ALICE , CHANG YA-JEN
IPC: A61K8/42 , A61K8/00 , C07C235/80 , C07C237/10
CPC classification number: C07H15/26 , A61K8/68 , A61K2800/91 , A61Q17/005 , C07H15/06 , C07H15/18
-
173.发明公开REISHI-MEDIATED ENHANCEMENT OF HUMAN TISSUE PROGENITOR CELL ADHESION AND DIFFERENTIATION 审中-公开灵芝介导的增强分子中有同人体组织祖细胞
公开(公告)号：EP2099465A4
公开(公告)日：2011-09-14
申请号：EP07838767
申请日：2007-09-21
Applicant: ACADEMIA SINICA
Inventor： TZU-BI SHIN DANIEL , CHEN WAN-YU , WONG CHI-HUEY
IPC: A61K36/074
CPC classification number: A61K36/074
Abstract: The present disclosure provides medicinally active extracts and fractions, and methods for using the same to increase eukaryotic cell adhesion, to increase differentiation of eukaryotic cells to produce increased numbers of B cells dendritic cells and chodrocytes, and to maintain undifferentiated hematopoietic cells. These methods and useful for modulating immune response, modulating hematopoietic activity, and engineering certain types of eukaryotic tissues.
-
174.发明公开ALPHA-SELECTIVE SIALYL PHOSPHATE DONORS FOR PREPARATION OF SIALOSIDES AND SIALOSIDE ARRAYS FOR INFLUENZA VIRUS DETECTION 有权ALPHA选择性SIALYLPHOSPHATSPENDER准备和唾液酸糖苷SIALOSIDANORDNUNGEN为了证明流感病毒
公开(公告)号：EP2411528A4
公开(公告)日：2013-09-11
申请号：EP10756991
申请日：2010-03-29
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , WU CHUNG-YI , CHENG TING-JEN R , HSU CHE-HSIUNG
IPC: C12P19/00
-
175.发明公开CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS 有权从抗体的镜像到GLOBO H及其碎片的癌症诊断
公开(公告)号：EP2307887A4
公开(公告)日：2011-09-21
申请号：EP09798419
申请日：2009-06-16
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , WU CHUNG-YI , WANG CHENG-CHI , YU ALICE L
IPC: G01N33/574 , G01N33/53
CPC classification number: G01N33/57488 , G01N33/57415
-
Patent Agency Ranking176.发明公开COMPOSITIONS AND METHODS FOR IDENTIFYING RESPONSE TARGETS AND TREATING FLAVIVIRUS INFECTION RESPONSES 审中-公开成分和方法识别检测元件和处理黄病毒感染
公开(公告)号：EP2257806A4
公开(公告)日：2011-06-15
申请号：EP08873539
申请日：2008-05-29
Applicant: ACADEMIA SINICA
Inventor： HSIEH SHIE-LIANG , WONG CHI-HUEY , HSU TSUI-LING , CHEN SZU-TING
IPC: G01N33/53 , A61K39/395 , C12Q1/68
CPC classification number: C07K16/2851 , A61K2039/505 , C07K2317/56 , C07K2317/76 , C07K2319/30 , G01N2333/18 , G01N2333/185 , G01N2500/02
Abstract: Cellular receptors are identified that induce plasma leakage and other negative effects when infected with flaviviruses, such as dengue virus or Japanese encephamyelitis virus. Using fusion proteins disclosed herein, the receptors to which a pathogen, such as flavivirus, binds via glycan binding are determined. Once the receptors are determined, the effect of binding to a particular receptor may be determined, wherein targeting of the receptors causing a particular symptom may be targeted by agents that interrupt binding of the pathogen to the receptor. Accordingly, in the case of dengue virus and Japanese encephamyelitis virus, TNF-α is released when the pathogen binds to the DLVR1/CLEC5A receptor. Interrupting the DLVR1/CLEC5A receptor with monoclonal antibodies reduced TNF-α secretion without affecting secretion of cytokines responsible for viral clearance thereby increasing survival rates in infected mice from nil to around 50%.
-
177.发明公开METHODS FOR PRODUCING VIRUS PARTICLES WITH SIMPLIFIED GLYCOSYLATION OF SURFACE PROTEINS 审中-公开VERFAHREN ZUR HERSTELLUNG VON VIRUSPARTIKELN MIT VEREINFACHTER GLYCOSYLIERUNG VONOBERFLÄCHENPROTEINEN
公开(公告)号：EP2635693A4
公开(公告)日：2014-05-07
申请号：EP11838917
申请日：2011-11-04
Applicant: ACADEMIA SINICA
Inventor： WONG CHI-HUEY , MA CHE , TSENG YUNG-CHIEH
CPC classification number: C12P21/005 , A61K39/12 , A61K39/145 , C07K14/005 , C12N7/00 , C12N2760/16111 , C12N2760/16121 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12Y302/01096 , G01N2333/00 , G01N2333/11 , Y02P20/52
Abstract: Methods for producing virus particles with simplified glycosylation on structural or surface proteins, such as mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1). When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles.
Abstract translation: 用于在结构或表面蛋白上产生简单糖基化的病毒颗粒的方法，例如甲型流感病毒的单糖基化形式，NIBRG-14（H5N1）。 当用作疫苗生产的目标时，这些位点的保守性质产生对病毒突变较不敏感的疫苗。 这样的方法可以包括使用糖基化抑制剂来生产具有简化的糖基化谱的病毒。
-
178.发明公开SYNTHESIS OF OSELTAMIVIR CONTAINING PHOSPHONATE CONGENERS WITH ANTI-INFLUENZA ACTIVITY 有权奥司他韦与膦酸酯同系有效对抗流感合成
公开(公告)号：EP2190439A4
公开(公告)日：2013-02-20
申请号：EP08828468
申请日：2008-08-29
Applicant: ACADEMIA SINICA
Inventor： FANG JIM-MIN , SHIE JIUN-JIE , WONG CHI-HUEY , CHENG YIH-SHYUN EDMOND , JAN JIA-TSRONG
IPC: A61K31/7076 , A61K9/16 , A61K31/7052 , C07C233/52 , C07C247/14 , C07H19/04
CPC classification number: A61K31/70 , A61K31/7076
-
179.发明公开COMPOSITIONS FOR INDUCING IMMUNE RESPONSES SPECIFIC TO GLOBO H AND SSEA3 AND USES THEREOF IN CANCER TREATMENT 审中-公开产生特异于GLOBO H和SSEA3的免疫反应的组合物及其在癌症治疗中的用途
公开(公告)号：EP2303286A4
公开(公告)日：2011-12-28
申请号：EP09794927
申请日：2009-06-16
Applicant: ACADEMIA SINICA
Inventor： YU ALICE L , YU JOHN , WONG CHI-HUEY
IPC: A61K31/716 , A61K31/164 , A61K31/7008 , A61P35/00
CPC classification number: A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
-
180.发明公开
公开(公告)号：EP2841066A4
公开(公告)日：2015-11-25
申请号：EP13775664
申请日：2013-04-12
Applicant: ACADEMIA SINICA , WONG CHI HEUY , FANG JIM-MIN , LIU KUNG-CHENG , JAN JIA-TSRONG , CHENG YIH SHYUN E , CHENG TING JEN R
Inventor： WONG CHI-HUEY , FANG JIM-MIN , LIU KUNG-CHENG , JAN JIA-TSRONG , CHENG YIH-SHYUN E , CHENG TING-JEN R
CPC classification number: A61K47/481 , A61K47/55
Abstract: Novel dual-targeted, bifunctional anti-influenza drugs formed by conjugation with anti-inflammatory agents are disclosed. Exemplary drugs according to the invention include caffeic acid (CA)-bearing zanamivir (ZA) conjugates ZA-7-CA (1), ZA-7-CA-amide (7) and ZA-7-Nap (43) for simultaneous inhibition of influenza virus neuraminidase and suppression of proinflammatory cytokines. Synthetic methods for preparation of these enhanced anti-influenza conjugate drugs are provided. The synthetic bifunctional ZA conjugates act synergistically towards protection of mice lethally infected by H1N1 or H5N1 influenza viruses. The efficacy of ZA-7-CA, ZA-7-CA-amide and ZA-7-Nap conjugates is much greater than the combination therapy of ZA with anti-inflammatory agents.
-
-
-
-
-
-
-
-
-
Search Results
184
records
(took 0.068 seconds)
