公开(公告)号：EP1511991A4

公开(公告)日：2011-04-20

申请号：EP03753106

申请日：2003-05-19

Applicant: LIFE TECHNOLOGIES CORP

Inventor： BOEGE STEVEN J ,  OLDMAN MARK ,  YOUNG EUGENE F

IPC: C12M1/00 ,  G01N21/25 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6463 ,  G01N2021/6478 ,  G01N2201/0627 ,  G01N2201/0628

公开(公告)号：EP1506390A4

公开(公告)日：2009-12-02

申请号：EP03738941

申请日：2003-05-19

Applicant: APPLERA CORP

Inventor： KING HOWARD G ,  BOEGE STEVEN J ,  YOUNG EUGENE F ,  OLDMAN MARK

IPC: G01N21/25 ,  G01N21/64

CPC classification number: G01N21/6428 ,  B01L7/52 ,  B01L2300/1805 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0628 ,  Y10S435/808

公开(公告)号：EP1459099A4

公开(公告)日：2006-08-23

申请号：EP02795414

申请日：2002-12-26

Applicant: INVERNESS MEDICAL SWITZERLAND

Inventor： FISH FALK ,  GREENBERG ZVI ,  FAKTOR OURIEL

IPC: G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N21/86 ,  G01N33/543

CPC classification number: G01N21/645 ,  G01N21/64 ,  G01N21/8483 ,  G01N33/549 ,  G01N2021/6439 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2201/0245 ,  G01N2201/062 ,  G01N2201/0628

Abstract: A system and method for detecting fluorescence in a sample (140). Where an efficient light source (120) projects light onto said sample, and where fluorescence in said sample is detected by a photodetector (180).

公开(公告)号：EP1459099A2

公开(公告)日：2004-09-22

申请号：EP02795414.8

申请日：2002-12-26

Applicant: Inverness Medical Switzerland GmbH

Inventor： FISH, Falk ,  GREENBERG, Zvi ,  FAKTOR, Ouriel

IPC: G01T1/00

CPC classification number: G01N21/645 ,  G01N21/64 ,  G01N21/8483 ,  G01N33/549 ,  G01N2021/6439 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2201/0245 ,  G01N2201/062 ,  G01N2201/0628

Abstract: A system and method for detecting fluorescence in a sample (140). Where an efficient light source (120) projects light onto said sample, and where fluorescence in said sample is detected by a photodetector (180).

公开(公告)号：EP1078245A1

公开(公告)日：2001-02-28

申请号：EP99924365.2

申请日：1999-05-17

Applicant: PE Corporation (NY)

Inventor： GAMBINI, Michael, R. ,  ATWOOD, John, G. ,  YOUNG, Eugene, F. ,  LAKATOS, Edward, J. ,  CERRONE, Anthony, L.

IPC: G01N21/25 ,  C12Q1/68

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

公开(公告)号：WO2017055437A1

公开(公告)日：2017-04-06

申请号：PCT/EP2016/073241

申请日：2016-09-29

Applicant: CAMBRIDGE DISPLAY TECHNOLOGY LIMITED

Inventor： BURROUGHES, Jeremy ,  WILSON, Richard ,  LEE, Andrew

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N2201/0628

Abstract: Fluorescence-based sensors having favourably low detection limits and high sensitivity are disclosed. The sensors comprise one or more solution processable colour filters that are used together with organic LEDs and photodiodes. The colour filters are used to narrow the wavelength range of the OLED emission and/or to reject any light from reaching the photodiode which is not from analyte fluorescence, thereby enhancing the device sensitivity.

Abstract translation: 公开了具有良好的检测极限和高灵敏度的基于荧光的传感器。 这些传感器包括与有机LED和光电二极管一起使用的一个或多个可解决处理的滤色器。 滤色器用于缩小OLED发射的波长范围和/或抑制任何光到达不是来自分析物荧光的光电二极管，从而提高器件灵敏度。

公开(公告)号：WO2015126373A1

公开(公告)日：2015-08-27

申请号：PCT/US2014/017028

申请日：2014-02-19

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Inventor： CASASANTA, Vincenzo

IPC: G01N21/55

CPC classification number: C12Q1/02 ,  G01N21/553 ,  G01N21/554 ,  G01N2201/0628 ,  G01N2201/0636 ,  G01N2201/0683

Abstract: A biosensing device, as well as methods of forming a biosensing device and detecting presence of a biofilm are disclosed. The biosensing device may include a substrate, at least one radiation source on the substrate, at least one radiation detector on the substrate, and at least one reflector arranged on the substrate such that radiation emitted from the at least one radiation source is reflected toward the at least one radiation detector. The at least one radiation detector may be configured to detect an intensity of the radiation reflected from the at least one reflector. A biofilm growth on a portion of the at least one reflector may cause a change in the intensity of the radiation reflected from the at least one reflector relative to radiation reflected from the reflector in the absence of the biofilm growth.

Abstract translation: 公开了一种生物传感装置，以及形成生物传感装置和检测生物膜存在的方法。 生物传感装置可以包括衬底，衬底上的至少一个辐射源，衬底上的至少一个辐射检测器和布置在衬底上的至少一个反射器，使得从至少一个辐射源发射的辐射朝向 至少一个辐射检测器。 所述至少一个辐射检测器可以被配置为检测从所述至少一个反射器反射的辐射的强度。 在不存在生物膜生长的情况下，至少一个反射器的一部分上的生物膜生长可导致从至少一个反射器反射的辐射的强度相对于从反射器反射的辐射的变化。

公开(公告)号：WO2014173772A1

公开(公告)日：2014-10-30

申请号：PCT/EP2014/057785

申请日：2014-04-16

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： BLEI, Gertrud ,  BOCK, Mario

IPC: A61M5/315 ,  G01D5/39 ,  G06F19/00 ,  A61M5/31

CPC classification number: G01N21/4738 ,  A61M5/31 ,  A61M5/3155 ,  A61M5/31568 ,  A61M2005/3126 ,  A61M2205/3306 ,  A61M2205/3379 ,  A61M2205/3553 ,  A61M2205/3592 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/6081 ,  A61M2205/8206 ,  A61M2209/04 ,  G01N2201/021 ,  G01N2201/0628 ,  G01N2201/0634 ,  G06F19/00 ,  G06F19/3468

Abstract: A sensor device configured to be attached to a drug delivery device and configured to illuminate the drug delivery device when attached, the sensor device comprising: an OLED (29) having a transparent first electrode, a transparent second electrode and a central layer disposed between the first and second electrodes, the central layer comprising at least one organic layer, the at least one organic layer configured to emit light through the transparent first electrode; and an optical sensor (25) arranged to receive light reflected from a surface of the drug delivery device, wherein the central layer of the OLED has a region without the at least one organic layer and wherein the optical sensor is arranged, when the sensor device is attached to the drug delivery device, to view a predetermined area of the surface of the drug delivery device through the region without the at least one organic layer.

Abstract translation: 传感器装置，其被配置为附接到药物递送装置并且被配置为在附着时照射所述药物递送装置，所述传感器装置包括：OLED（29），其具有透明的第一电极，透明的第二电极和中心层， 第一和第二电极，所述中心层包括至少一个有机层，所述至少一个有机层被配置为通过所述透明第一电极发光; 以及光学传感器（25），布置成接收从所述药物递送装置的表面反射的光，其中所述OLED的中心层具有不具有所述至少一个有机层的区域，并且其中所述光学传感器被布置在所述传感器装置 附接到药物递送装置，以通过该区域观察药物递送装置的表面的预定区域，而没有至少一个有机层。

公开(公告)号：WO2013181433A3

公开(公告)日：2014-01-30

申请号：PCT/US2013043426

申请日：2013-05-30

Applicant: UNIV MICHIGAN STATE

Inventor： KRAMER DAVID ,  CRUZ JEFFREY ,  HALL CHRISTOPHER ,  KOVAC WILLIAM KENT ,  ZEGARAC ROBERT

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6408 ,  G01N21/6456 ,  G01N33/0098 ,  G01N33/025 ,  G01N2021/635 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0627 ,  G01N2201/0628

Abstract: Chlorophyll fluorescence may be studied in response to a variety of environmental cues or conditions by growing phototrophic organisms under actinic illumination. Such illumination may be punctuated or disrupted to gain information about the photosynthetic properties or performance of the phototrophic organism. Instruments or devices for carrying out the method are also described.

Abstract translation: 可以通过在光化照射下生长光养生物来响应各种环境线索或条件来研究叶绿素荧光。 这种照明可能被打断或破坏以获得关于光合生物的光合性质或性能的信息。 还描述了用于执行该方法的仪器或装置。

公开(公告)号：WO2013159189A1

公开(公告)日：2013-10-31

申请号：PCT/CA2013/000383

申请日：2013-04-18

Applicant: TRANSFERT PLUS, S.E.C.

Inventor： LEFÈVRE, Florent ,  IZQUIERDO, Ricardo ,  JUNEAU, Philippe

IPC: G01N21/76 ,  C12M1/12 ,  C12M1/34 ,  C12M1/42 ,  C12Q1/02 ,  G01N1/00 ,  G01N21/00 ,  G01N21/01 ,  G01N27/00

CPC classification number: G01N33/1866 ,  C12M21/02 ,  C12M23/16 ,  C12Q1/02 ,  G01N21/64 ,  G01N21/6486 ,  G01N27/30 ,  G01N33/1893 ,  G01N2033/184 ,  G01N2201/0628 ,  G01N2201/068 ,  G01N2520/00

Abstract: There are provided methods and apparatuses for evaluating water pollution. The apparatus comprises at least one light source for exciting or causing activity of at least one type of microorganism or biological material; at least one photodetector for detecting a level of fluorescent light; and a chip disposed between the at least one light source and the detector, the chip comprising at least one microfluidic channel disposed for being exposed to light from the at least one light source and dimensioned for receiving a composition comprising the at least one type of microorganism or biological material and a water sample to be evaluated.

Abstract translation: 提供了评估水污染的方法和设备。 该装置包括用于激发或引起至少一种类型的微生物或生物材料的活性的至少一个光源; 用于检测荧光水平的至少一个光电检测器; 以及设置在所述至少一个光源和所述检测器之间的芯片，所述芯片包括至少一个微流体通道，所述至少一个微流体通道被设置用于暴露于来自所述至少一个光源的光并被设计成用于接收包含所述至少一种类型的微生物 或生物材料和要评估的水样。