公开(公告)号：KR101427781B1

公开(公告)日：2014-08-13

申请号：KR1020110091796

申请日：2011-09-09

Applicant: (주)씨앤팜

Inventor： 손연수 ,  전용주

IPC: C07D251/24 ,  C07D251/12 ,  C07D251/02 ,  A61K31/337

CPC classification number: A61K47/42 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/4833 ,  A61K31/337 ,  A61K47/24 ,  C07F9/65815

Abstract: 본 발명은 생체 적합성을 갖는 양친성 고리형 포스파젠 삼합체 및 그 제조 방법에 관한 것이다. 또한 본 발명은 상기 양친성 고리형 포스파젠 삼합체로 미셀(micelle)화한 소수성 약물제제 및 그 제조방법에 관한 것이다.

公开(公告)号：KR101088762B1

公开(公告)日：2011-12-01

申请号：KR1020090005980

申请日：2009-01-23

Applicant: (주)씨앤팜

Inventor： 최진호 ,  김병철 ,  박대환

IPC: A61K8/362 ,  A61Q11/00 ,  A61K8/96

Abstract: 본 발명은 에이코사펜타에노산(EPA)을 포함하는 탈모 방지 및 발모 촉진용 유무기 나노하이브리드 복합체 및 상기 복합체를 포함하는 발모 촉진용 조성물에 관한 것으로서, 더욱 상세하게는 층상 금속염의 층간에 에이코사펜타에노산이 삽입된 것을 특징으로 하며, 외부 환경 변화에 안정성이 뛰어나고, 약물전달력이 탁월한 탈모 방지 및 발모 촉진용 나노하이브리드 복합체 및 상기 나노하이브리드 복합체를 포함하는 발모 촉진용 조성물에 관한 것이다.

公开(公告)号：KR1020110028981A

公开(公告)日：2011-03-22

申请号：KR1020090086644

申请日：2009-09-14

Applicant: (주)씨앤팜

Inventor： 최진호 ,  박대환 ,  조재용

IPC: C12N15/11 ,  A61K47/48 ,  A61P35/00

CPC classification number: C12N15/1138 ,  A61K31/7105 ,  A61K47/66 ,  C12N2310/14 ,  C12N2310/351

Abstract: PURPOSE: An siRNA-inorganic layered double hydroxide nanohybrid is provided to improve tumor-specific transfer efficiency. CONSTITUTION: An siRNA-inorganic layered double hydroxide nanohybrid is denoted by chemical formula 1(M(II)_1-Xm(III)_x(OH)_2]^X+[S][T]). In chemical formula 1, M(II) is bivalent metal cation, and M(III) is trivalent metal cation. The siRNA is derived from surviving gene. The siRNA is denoted by a base sequence selected from sequence numbers 1-9. A pharmaceutical composition for treating tumor contains the nanohybrid and pharmaceutically acceptable carrier. The composition is manufacture in the form of tablet, capsule, liquid, injection, ointment, or syrup.

Abstract translation: 目的：提供siRNA-无机层状双氢氧化物纳米混合物，以改善肿瘤特异性转移效率。 构成：siRNA-无机层状双氢氧化物纳米混合物由化学式1（M（II）_1-Xm（III）_x（OH）_2] ^ X + [S] [T]表示。 在化学式1中，M（II）是二价金属阳离子，M（III）是三价金属阳离子。 siRNA衍生自存活基因。 siRNA由选自序列号1-9的碱基序列表示。 用于治疗肿瘤的药物组合物含有纳米杂交体和药学上可接受的载体。 组合物以片剂，胶囊，液体，注射剂，软膏或糖浆的形式制造。

公开(公告)号：KR1020100086647A

公开(公告)日：2010-08-02

申请号：KR1020090005980

申请日：2009-01-23

Applicant: (주)씨앤팜

Inventor： 최진호 ,  김병철 ,  박대환

IPC: A61K8/362 ,  A61Q11/00 ,  A61K8/96

CPC classification number: A61K8/18 ,  A61K8/19 ,  A61K8/362 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/00 ,  Y10S514/88

Abstract: PURPOSE: An organic/inorganic nanohybrid complex containing eicosapentaenoic acid(EPA) is provided to maximize hair growth effect with stability to heat, light, air, and oxygen. CONSTITUTION: A nanohybrid complex for promoting hair growth and preventing hair loss is inserted between metal salt layers. The metal salt is Layered double hydroxide(LDH) or Zinc Basic SaltF(ZBS). LDH is denoted by structural formula([M^2+_(1-x)N^3+_x(OH)^2]A_x yH^2O). A composition for preventing hair loss and promoting hair growth contains 0.01-20 weight% of nanohybrid complex as an active ingredient.

Abstract translation: 目的：提供含有二十碳五烯酸（EPA）的有机/无机纳米杂交复合物，以最大化毛发生长效应，对热，光，空气和氧气具有稳定性。 构成：用于促进毛发生长和预防脱发的纳米杂交复合物插入金属盐层之间。 金属盐是层状双氢氧化物（LDH）或锌基盐（ZBS）。 LDH由结构式（[M ^ 2 + _（1-x）N ^ 3 + _x（OH）^ 2] A_x yH ^ 2O表示。 用于防止脱发和促进毛发生长的组合物含有0.01-20重量％的纳米杂交复合物作为活性成分。

公开(公告)号：KR1020080031763A

公开(公告)日：2008-04-11

申请号：KR1020060097719

申请日：2006-10-05

Applicant: (주)씨앤팜

Inventor： 박태운

IPC: A61K47/48 ,  A61P35/00

CPC classification number: A61K47/50 ,  A61K47/02

Abstract: A target delivery method of an anti-cancer drug is provided to increase in vivo retention time and selectivity to cancer cells by increasing molecular weight with LDH(layered double hydroxide), minimize side effects and maximize drug effects by controlling the size of LDH nanoparticles, selectively delivering the drug to cancer cells, and promoting cell entrance and delivery by endocytosis. A method for inhibiting growth of cancer cells selectively comprises the steps of: regulating the size of metal layered double hydroxide(LDH) to 50-450 nm and inserting an anti-cancer drug MTX(methotrexate) between layers of the LDH through ion exchange to prepare a MTX/LDH hybrid; and administering the MTX/LDH hybrid to a cancer patient through injection, wherein the cancer cell is MNNG/HOS(N-methyl-N'-nitro-N-nitroso-guanidine/human osteosarcoma).

Abstract translation: 提供抗癌药物的靶递送方法，以通过用LDH（层状双氢氧化物）增加分子量来增加体内保留时间和对癌细胞的选择性，通过控制LDH纳米颗粒的尺寸来最小化副作用并最大化药物作用， 选择性地将药物递送至癌细胞，并通过内吞促进细胞进入和递送。 选择性地抑制癌细胞生长的方法包括以下步骤：将金属层状双氢氧化物（LDH）的尺寸调节至50-450nm，并通过离子交换将LDH的层之间的抗癌药物MTX（甲氨蝶呤）插入到 制备MTX / LDH杂交体; 并通过注射给予癌症患者MTX / LDH杂交体，其中癌细胞是MNNG / HOS（N-甲基-N'-硝基-N-亚硝基胍/人骨肉瘤）。

公开(公告)号：KR100807358B1

公开(公告)日：2008-02-28

申请号：KR1020070038055

申请日：2007-04-18

Applicant: (주)씨앤팜

Inventor： 손연수 ,  유지영 ,  전용주

IPC: C07F17/02 ,  C07F9/06 ,  C07F9/02 ,  B82Y5/00

CPC classification number: C07F15/0093

Abstract: A cyclotriphosphazene-platinum(II) conjugate is provided to show high selectivity on a cancer tissue and excellent anticancer effect due to excellent permeation-retention property effect on the cancer tissue. A cyclotriphosphazene-platinum(II) conjugate is represented by the formula(1), where n is 7, 12 or 16; m is 0, 1 or 2; x is 1; each y and z is respectively 0 or 1; and each R, R' and R' is respectively selected from the group consisting of (CH3)2CH-, (CH3)2CHCH2-, (C2H5)(CH3)CH- and (C6H5)CH2-; and A and A' are independently an amine monodendate or A and A' may bound to each other to form a chelate type diamine didendate. An anticancer composition comprises the cyclotriphosphazene-platinum(II) conjugate as an effective ingredient. A method for preparing the conjugate comprises the steps of: (a) hydrolyzing a cyclotriphosphazene represented by the formula(3) to prepare an alkali metal salt or an alkali earth metal salt thereof represented by the formula(4); and (b) coupling the compound of the formula(4) to a (diamine) platinum(II) complex represented by the formula(5), where the n, m, x, y, z, R, R', R", A and A' are same as defined above; M is two alkali metal ions selected from the group consisting of potassium ion and sodium ion or Ba^2+; and L is one or two anion ligand(s) selected from the group consisting of sulfuric acid ion and nitric acid ion.

Abstract translation: 提供了一种环三磷腈 - 铂（II）缀合物，以显示对癌组织的高选择性，并且由于对癌组织的优异的渗透保留性效应而具有优异的抗癌作用。 环三磷腈 - 铂（II）缀合物由式（1）表示，其中n为7,12或16; m为0,1或2; x为1; 每个y和z分别为0或1; 并且每个R，R'和R'分别选自（CH 3）2 CH-，（CH 3）2 CHCH 2 - ，（C 2 H 5）（CH 3）CH-和（C 6 H 5）CH 2 - ; 并且A和A'独立地是单一单胺或A和A'可以彼此结合以形成螯合型二胺胺二酸酯。 抗癌组合物包含环三磷腈 - 铂（II）缀合物作为有效成分。 制备共轭物的方法包括以下步骤：（a）水解由式（3）表示的环三磷腈以制备由式（4）表示的碱金属盐或碱土金属盐; 和（b）将式（4）的化合物与由式（5）表示的（二胺）铂（II）络合物偶合，其中n，m，x，y，z，R，R'，R“ ，A和A'与上述相同; M是选自钾离子和钠离子或Ba 2+的两种碱金属离子; L是选自以下的一种或两种阴离子配体： 的硫酸离子和硝酸离子。

公开(公告)号：KR1020040063878A

公开(公告)日：2004-07-14

申请号：KR1020040048061

申请日：2004-06-25

Applicant: (주)씨앤팜

Inventor： 최진호 ,  한양수 ,  황성호 ,  이지원 ,  양재훈 ,  이선영

IPC: A61K8/67 ,  A61K8/19 ,  A61Q1/00

CPC classification number: A61K8/492 ,  A61K8/02 ,  A61K8/25 ,  A61K8/26 ,  A61K8/27 ,  A61K8/365 ,  A61K8/368 ,  A61K8/498 ,  A61K8/671 ,  A61K8/678 ,  A61K2800/56 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/08 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2998

Abstract: PURPOSE: Provided is a material for cosmetics which involves excellent stability, low toxicity, low stimulation, sustained release and high diffusion, and is made in economic and effective manners. CONSTITUTION: The cosmetic material is a hybrid material of vitamin C and lamellar metallic hydroxides. A method of manufacturing the hybrid material comprises the steps of: reacting the starting material in a basic solution to make lamellar metallic hydroxide salts; and diffusing the lamellar metallic hydroxide salts in a solvent of water, or a mixed solvent, and dissolving the vitamin C, followed by ion exchange reacting it.

Abstract translation: 目的：提供化妆品的优异稳定性，低毒性，低刺激性，持续释放和高扩散性，并以经济有效的方式制备。 构成：化妆品是维生素C和层状金属氢氧化物的混合材料。 制造混合材料的方法包括以下步骤：使起始材料在碱性溶液中反应制成片状金属氢氧化物盐; 并将层状金属氢氧化物盐扩散到水或混合溶剂的溶剂中，并溶解维生素C，然后进行离子交换反应。

公开(公告)号：KR100359716B1

公开(公告)日：2003-04-21

申请号：KR1019980037497

申请日：1998-09-11

Applicant: (주)씨앤팜

Inventor： 최진호 ,  곽서영 ,  박종상

IPC: C07H19/00

CPC classification number: C12N15/1003

Abstract: Disclosed is a bio-inorganic hybrid composite for retaining and carrying bio-materials with stability and reversible dissociativity, represented by the following chemical Formula I and a method for preparing the same. The bio-inorganic hybrid composite is prepared by (a) coprecipitating with an alkaline material an aqueous solution comprising a bivalent metal (M(II)) and a trivalent metal (N(III)) at a molar ratio satisfying the condition of 1/5 ≤b/(a+b)≤ 1/2 wherein a and b represent a mole number of M and N, respectively, to form a stable layered double hydroxide in which anions are intercalated and (b) subjecting the intercalated anions to ion exchange reaction with a bio-material to compensate for layer charges of the layered double hydroxide. This composite is harmless to the body and artificially controls the appropriate expression of the bio-material retained therein. ÄM  1-xN  x(OH)2Ü ÄABIO  Üx/n.yH2O wherein, M is a bivalent metal cation; N is a trivalent metal cation; ABIO is an anionic bio-material with n charges; x is a rational number between 0 to 1; and y is a positive number.

Abstract translation: 公开了一种用于保持和携带具有稳定性和可逆解离性的生物材料的生物 - 无机混合复合材料，由以下化学式I表示，及其制备方法。 该生物 - 无机杂化复合材料通过（a）以满足条件1/2的摩尔比与碱性材料共沉淀包含二价金属（M（II））和三价金属（N（III））的水溶液来制备。 5＆amp; le; b /（a + b）＆amp; le; 1/2，其中a和b分别代表M和N的摩尔数，以分别形成其中插入有阴离子的稳定的层状双氢氧化物，和（b）使插入的阴离子与生物材料发生离子交换反应以补偿 层状双氢氧化物的层电荷。 这种复合材料对身体无害并且人为控制其中保留的生物材料的适当表现。 ＆AUML; M＆LT; 2+;＆安培; hairsp; 1-XN＆LT; 3+;＆安培; hairsp; X（OH）2＆Uuml; ＆Auml; ABIO＆amp; hairsp;＆lt; n＆gt; x / n.yH 2 O其中，M是二价金属阳离子; N是三价金属阳离子; ABIO是一种具有n电荷的阴离子生物材料; x是0到1之间的有理数; y是一个正数。

公开(公告)号：KR101118691B1

公开(公告)日：2012-03-12

申请号：KR1020090086644

申请日：2009-09-14

Applicant: (주)씨앤팜

Inventor： 최진호 ,  박대환 ,  조재용

IPC: C12N15/11 ,  A61K47/48 ,  A61P35/00

Abstract: 본 발명은 강력한 유전자 치료제인 siRNA (small interfering RNA)와 표적지향성 층상형 무기 수산화물과의 나노혼성체, 그 제조방법, 및 표적지향성 siRNA-층상형 무기 수산화물 나노혼성체를 함유하는 종양 치료용 약학 조성물에 관한 것이다.
본 발명에 따른 나노혼성체는, 종양 마커와 특이적으로 결합할 수 있는 표적지향성 다작용기 리간드가 결합된 층상형 무기 수산화물과 나노혼성체를 이루고 있는 siRNA의 생체 내 안정성이 종양특이적 전달 효율을 향상시켜 비교적 낮은 농도의 투여량에서 siRNA의 종양치료 활성을 나타내므로 범용적인 표적지향성 종양치료에 널리 활용될 수 있을 것이다.
siRNA, 층상형 무기 수산화물, 표적지향성, 나노하이브리드, 유전자 치료제

公开(公告)号：KR1020110127496A

公开(公告)日：2011-11-25

申请号：KR1020100047013

申请日：2010-05-19

Applicant: (주)씨앤팜

Inventor： 최진호 ,  박명철

IPC: F24F6/12 ,  F24F3/16 ,  F24F11/02

CPC classification number: Y02A50/22 ,  Y02B30/80 ,  F24F6/12 ,  A01M29/18 ,  F24F3/16 ,  F24F2003/1675 ,  F24F2003/1692 ,  F24F2006/008

Abstract: PURPOSE: A multi function humidifier is provided that the various additional function of an air cleaning function, antibiotic/disinfection function, a mite removing function, and an oxygen generation function etc, are embodied in one product. CONSTITUTION: A multi function humidifier comprises an ultrasonic generator(120) for the exterminating acarid, a humidification part(110), a phytoncide humidification part(130), an oxygen generator(140), an air purification part(150). The ultrasonic generator for the exterminating acarid generates the ultrasonic wave of 25-65kHz frequency band. It is created the humidification particle from the water provided from the water pail and the humidification part discharges. It dilutes the phytoncide extract with the water of the humidification part and the phytoncide humidification part volatilizes among the air. It occurs the oxygen and it directly discharges among the air or the oxygen generator mixes in the water of the humidification part. After inhaling the external air and eliminating the dust or contaminant, the air purification part discharges.

Abstract translation: 目的：提供一种多功能加湿器，其具有空气清洁功能，抗生素/消毒功能，除尘功能和氧气产生功能等的各种附加功能。 构成：多功能加湿器包括用于消灭螨虫的超声波发生器（120），加湿部分（110），植酸剂加湿部分（130），氧气发生器（140），空气净化部分（150）。 用于消除螨虫的超声波发生器产生25-65kHz频带的超声波。 从水桶提供的水中形成加湿颗粒，加湿部分排出。 用加湿部分的水稀释植物提取物，并且空气中的植酸苷加湿部分挥发。 发生氧气，并直接在加湿部分的水中排出空气或氧气发生器混合物。 吸入外部空气并除去灰尘或污染物后，空气净化部件排出。