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    STANDOFF TRACE CHEMICAL DETECTION WITH ACTIVE INFRARED SPECTROSCOPY
    11.
    发明申请
    STANDOFF TRACE CHEMICAL DETECTION WITH ACTIVE INFRARED SPECTROSCOPY 审中-公开

    公开(公告)号：WO2018213212A1

    公开(公告)日：2018-11-22

    申请号：PCT/US2018/032623

    申请日：2018-05-15

    Applicant: LEIDOS, INC.

    Inventor： IFARRAGUERRI, Augie ,  GORIN, Brian ,  CAMACHO, J. Frank ,  CHRISTIAN, Noah ,  RICE, Robert

    IPC: G01J3/30 ,  G01J3/45 ,  G01J3/453 ,  G01J9/02 ,  G01N21/35 ,  H03G3/00

    Abstract: A system and process scans a target area at a distance of 3-30 m for one or more materials. Scanning is performed by a coherent transmit beam aimed with the help of a thermal camera. The active source of the beam is a supercontinuum (SC) laser. The transmitted source beam is modulated by a high-speed Fourier-transform spectrometer prior to interaction with the target. Target reflected source beam is detected by an infrared detector, along with a reference portion of the transmitted source beam, as a series of interferograms; passed through a digitizer for digitizing the interferograms; and processed to producing spectrograms, wherein the spectrograms are indicative of one or more materials on the target.

    SYSTEM AND METHOD FOR IMPLEMENTING ADAPTIVE PULSE POSITION MODULATION (APPM) FOR IMPROVED OPTICAL COMMUNICATIONS PERFORMANCE
    14.
    发明申请
    SYSTEM AND METHOD FOR IMPLEMENTING ADAPTIVE PULSE POSITION MODULATION (APPM) FOR IMPROVED OPTICAL COMMUNICATIONS PERFORMANCE 审中-公开
    用于实现改进的光通信性能的自适应脉冲位置调制（APPM）的系统和方法

    公开(公告)号：WO2017152173A1

    公开(公告)日：2017-09-08

    申请号：PCT/US2017/020932

    申请日：2017-03-06

    Applicant: LEIDOS, INC.

    Inventor： HARRIS, Susan ,  KREPEL, Mark ,  LUNDBERG, James ,  FISHER, Chris

    IPC: G02B26/08 ,  H04B10/00 ,  H04B10/10 ,  H04B10/22

    CPC classification number: H04B10/80 ,  H04B10/07953 ,  H04B10/112 ,  H04B10/40 ,  H04B10/524 ,  H04B10/564 ,  H04B13/02

    Abstract: The Adaptable Pulse Position Modulation (APPM) optical communication system and process facilitate wireless communications through turbid mediums including, but not limited to, smoke, airborne dust, mist, fog, clouds, water, seawater and water-to-air (air-to-water) interfaces by controlling the signal gain at the optical detector and controlling of the signal encoding to allow high data rate operation when the signal to noise ratio is high. The system also supports signal encoding redundancy to maintain good connectivity at the cost of the communication channel data rate as the signal to noise degrades.

    Abstract translation: 可适应脉冲位置调制（APPM）光通信系统和过程促进了通过混浊介质的无线通信，所述混浊介质包括但不限于烟雾，空气中的灰尘，雾，雾，云，水，海水和水 通过控制光学检测器处的​​信号增益和信号编码的控制以在信噪比高时允许高数据速率操作来实现对空（空对水）接口。 该系统还支持信号编码冗余，以保持良好的连接性，同时降低通信信道数据速率，降低噪声信号。

    AN IMPROVED LOW-POWER MASS INTERROGATION SYSTEM AND ASSAY FOR DETERMINING VITAMIN D LEVELS
    16.
    发明申请
    AN IMPROVED LOW-POWER MASS INTERROGATION SYSTEM AND ASSAY FOR DETERMINING VITAMIN D LEVELS 审中-公开

    公开(公告)号：WO2019213130A3

    公开(公告)日：2019-11-07

    申请号：PCT/US2019/029991

    申请日：2019-04-30

    Applicant: LEIDOS, INC.

    Inventor： CHRISTIAN, Noah, Peter

    IPC: H01J49/04

    Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

    PD-1 PEPTIDE INHIBITORS
    17.
    发明申请
    PD-1 PEPTIDE INHIBITORS 审中-公开
    PD-1肽抑制剂

    公开(公告)号：WO2018053218A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/051697

    申请日：2017-09-15

    Applicant: LEIDOS, INC.

    Inventor： GUTIERREZ, Gabriel M. ,  VINAYAKA, Kotraiah ,  PANNUCCI, James ,  AYALA, Ramses

    IPC: A61K38/10 ,  C07K7/08 ,  A61P35/00 ,  A61P31/00

    Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

    Abstract translation: 本公开提供了对检查点受体“程序性死亡1”具有强亲和力的肽。 （PD-1）。 这些肽阻断PD-1与其配体PDL1的相互作用，因此可以用于各种治疗目的，例如抑制包括癌症在内的过度增殖性病症的进展，治疗感染性疾病，增强对疫苗接种的反应和治疗败血症。

    VIRAL CONSTRUCTS FOR USE IN ENHANCING T-CELL PRIMING DURING VACCINATION
    18.
    发明申请
    VIRAL CONSTRUCTS FOR USE IN ENHANCING T-CELL PRIMING DURING VACCINATION 审中-公开

    公开(公告)号：WO2022169895A1

    公开(公告)日：2022-08-11

    申请号：PCT/US2022/014970

    申请日：2022-02-02

    Applicant: GEOVAX, INC. ,  LEIDOS, INC.

    Inventor： HAUSER, Mary Jo ,  DOMI, Arban ,  GUTIERREZ, Gabriel ,  PANNUCCI, James ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy ,  BUONTEMPO, Peter ,  BROWNE, Cecille

    IPC: A61K35/768 ,  C12N15/86 ,  C12N15/87 ,  C12N15/90

    Abstract: The invention provides virus-based expression vectors comprising immune-checkpoint inhibitor inserts for use as effective adjuvants in enhancing T-cell priming to an antigen in a host during a vaccination regimen. In particular, the compositions described herein are novel recombinant modified vaccinia Ankara (MVA) viral constructs encoding one or more peptides which, upon administration, are expressed in a multimer conformation and subsequently cleaved and secreted from the cell. Such peptides are capable of downregulating an immune checkpoint pathway, for example, by inhibiting the activation of programmed-cell death protein 1 (PD-1), programed cell death ligand 1 (PD-L1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), or another immune checkpoint regulator, or a combination thereof. When used in concert with the administration of an antigen during a vaccination strategy, the immune checkpoint expressing MV A viral construct provides significantly improved antigen-specific CD8+ T cell expansion, increased antigenic responses, and improved vaccination efficacy.

    LAG3 BINDING PEPTIDES
    19.
    发明申请
    LAG3 BINDING PEPTIDES 审中-公开

    公开(公告)号：WO2020237050A1

    公开(公告)日：2020-11-26

    申请号：PCT/US2020/033996

    申请日：2020-05-21

    Applicant: LEIDOS, INC.

    Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  PANNUCCI, James ,  MANSOUR, Marc

    IPC: A61P35/00 ,  C07K7/00 ,  A61P25/28

    Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

    SENSOR ARRAY MULTIPLEXER
    20.
    发明申请
    SENSOR ARRAY MULTIPLEXER 审中-公开

    公开(公告)号：WO2020061045A1

    公开(公告)日：2020-03-26

    申请号：PCT/US2019/051513

    申请日：2019-09-17

    Applicant: LEIDOS, INC.

    Inventor： BOLER, Mitchell, Eric ,  JOHNSON, Steven, Michael

    IPC: G01S7/52 ,  G01S7/539 ,  G01S15/00 ,  G01S15/04 ,  G01S15/87 ,  G01S15/88

    Abstract: A system for collecting data from multiple sensors at a central node is described. The system includes multiple pairs of sensor array multiplexers (SAMs) and sensors connected in series along the length of two cables each having a twisted wire pair. A first end of the length of the two cables is connected to the central node for receiving data from each of the multiple pairs. The multiple pairs include sensors of at least two different types, which may have different sampling rates. The first cable carries timing data between the multiple pairs and the central node and the second cable carries sensor data between the multiple pairs and the central node.

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