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    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE
    11.
    发明申请
    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE 审中-公开
    用于激活装置的截止阀的装置和方法

    公开(公告)号：WO2014051427A1

    公开(公告)日：2014-04-03

    申请号：PCT/NL2013/050687

    申请日：2013-09-25

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： VROUWE, Elwin Xander ,  DHINDSA, Manjeet ,  OLDE RIEKERINK, Marinus Bernardus ,  VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0688 ,  F16K99/0017 ,  F16K99/0042 ,  F16K2099/0084

    Abstract: The invention relates to a device (20), comprising: • - a liquid container (21) for containing a liquid; • - a capillary-stop valve (22) that is in medium through flow connection with said liquid container (21) for stopping said liquid in said container from flowing out of said container via said capillary- stop valve (22); • - a first electrode (7) being arranged such that in use said first electrode is in contact with said liquid in said liquid container; • - a second electrode (2) that is spaced apart from said capillary- stop valve by an electrically insulating medium gap (24), and • - a voltage source (V) connected to said first and second electrode which is activatable for applying an electric potential difference at the first and second electrode such that the liquid in the liquid container is attracted in the direction of said second electrode so as to allow the liquid to overcome the stopping effect of the capillary- stop valve for discharging liquid from said liquid container via said capillary-stop valve. The invention also relates to a method for activating a capillary-stop valve of a device.

    Abstract translation: 本发明涉及一种装置（20），包括： - 用于容纳液体的液体容器（21）; • - 与所述液体容器（21）处于中等通过流动连接的用于阻止所述容器中的液体经由所述毛细管截止阀（22）从所述容器流出的毛细管截止阀（22）; ·第一电极（7）被布置为使得所述第一电极在所述液体容器中与所述液体接触; - 第二电极（2），其通过电绝缘介质间隙（24）与所述毛细管截止阀间隔开，和 - 连接到所述第一和第二电极的电压源（V），其可激活以施加 在第一和第二电极处的电位差使得液体容器中的液体沿着所述第二电极的方向被吸引，以便液体克服用于从液体容器排出液体的毛细管截止阀的停止效果 通过所述毛细管截止阀。 本发明还涉及用于激活装置的毛细管截止阀的方法。

    Method of bonding two substrates and device manufactured thereby
    14.
    发明授权
    Method of bonding two substrates and device manufactured thereby 有权
    接合两个基板的方法和由此制造的装置

    公开(公告)号：US09573804B2

    公开(公告)日：2017-02-21

    申请号：US14361683

    申请日：2012-12-21

    Applicant: Micronit Microfluidics B.V.

    Inventor： Ronny Van 'T Oever ,  Marko Theodoor Blom ,  Jeroen Haneveld ,  Johannes Oonk ,  Marinus Bernardus Olde Riekerink ,  Peter Tijssen ,  Hendrik Jan Hildebrand Tigelaar ,  Jean-Noël Fehr ,  Jean-Christophe Roulet ,  Amitava Gupta

    IPC: B81C1/00 ,  H01L23/10 ,  H01L21/50 ,  B81C3/00 ,  C23F1/02

    CPC classification number: B81C1/00269 ,  B81B2201/058 ,  B81C3/001 ,  B81C2201/0132 ,  B81C2203/0118 ,  B81C2203/019 ,  C23F1/02 ,  H01L21/50 ,  H01L23/10 ,  H01L2924/0002 ,  Y10T428/239 ,  H01L2924/00

    Abstract: The invention relates to method for bonding at least two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, by using an intermediate thin film metal layer for providing the bonding, said method comprising the following steps of: a) providing said two substrates; b) depositing said thin film metal layer on at least a part of a surface of a first substrate of the two substrates; c) bringing a surface of the second substrate into contact with said thin film metal layer on said surface of the first substrate such that a bonding between the second substrate and the thin film metal layer on the first substrate is provided; and d) at least locally strengthening the bonding between the second substrate and the thin film metal layer on the first substrate. The invention also relates to a device comprising two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, and an intermediate thin film metal layer.

    Abstract translation: 本发明涉及通过使用用于提供接合的中间薄膜金属层将至少两个基板（例如由玻璃，硅，陶瓷，铝或硼制成）接合的方法，所述方法包括以下步骤：a） 提供所述两个基板; b）将所述薄膜金属层沉积在所述两个基板的第一基板的表面的至少一部分上; c）使所述第二基板的表面与所述第一基板的所述表面上的所述薄膜金属层接触，从而提供所述第二基板和所述第一基板上的所述薄膜金属层之间的接合; 以及d）至少局部加强第一基板上的第二基板和薄膜金属层之间的接合。 本发明还涉及包括例如由玻璃，硅，陶瓷，铝或硼制成的两个基底和中间薄膜金属层的器件。

    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE
    15.
    发明申请
    DEVICE AND METHOD FOR ACTIVATING A CAPILLARY-STOP VALVE OF A DEVICE 审中-公开
    用于激活装置的截止阀的装置和方法

    公开(公告)号：US20150238961A1

    公开(公告)日：2015-08-27

    申请号：US14431161

    申请日：2013-09-25

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： Elwin Xander Vrouwe ,  Manjeet Dhindsa ,  Marinus Bernardus Olde Riekerink ,  Ronny Van 'T Oever ,  Marko Theodoor Blom

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/502738 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0415 ,  B01L2400/0688 ,  F16K99/0017 ,  F16K99/0042 ,  F16K2099/0084

    Abstract: The invention relates to a device (20), comprising: a liquid container (21) for containing a liquid; a capillary-stop valve (22) that is in medium through flow connection with said liquid container (21) for stopping said liquid in said container from flowing out of said container via said capillary-stop valve (22); a first electrode (7) being arranged such that in use said first electrode is in contact with said liquid in said liquid container; a second electrode (2) that is spaced apart from said capillary-stop valve by an electrically insulating medium gap (24), and a voltage source (V) connected to said first and second electrode which is activatable for applying an electric potential difference at the first and second electrode such that the liquid in the liquid container is attracted in the direction of said second electrode so as to allow the liquid to overcome the stopping effect of the capillary-stop valve for discharging liquid from said liquid container via said capillary-stop valve. The invention also relates to a method for activating a capillary-stop valve of a device.

    Abstract translation: 本发明涉及一种装置（20），包括：用于容纳液体的液体容器（21）; 与所述液体容器（21）处于介质中流动连接的用于阻止所述容器中的液体经由所述毛细管截止阀（22）从所述容器流出的毛细管截止阀（22）; 第一电极（7）被布置成使得在使用中所述第一电极与所述液体容器中的所述液体接触; 通过电绝缘介质间隙（24）与所述毛细管截止阀间隔开的第二电极（2）和连接到所述第一和第二电极的电压源（V），所述电压源可激活以施加电位差 所述第一和第二电极使得所述液体容器中的液体沿所述第二电极的方向被吸引，从而允许所述液体克服所述毛细管截止阀的停止作用，所述停止效应通过所述毛细管 - 截止阀。 本发明还涉及用于激活装置的毛细管截止阀的方法。

    Method of Bonding Two Substrates and Device Manufactured Thereby
    16.
    发明申请
    Method of Bonding Two Substrates and Device Manufactured Thereby 有权
    粘合两个基板的方法和由此制造的装置

    公开(公告)号：US20140335301A1

    公开(公告)日：2014-11-13

    申请号：US14361683

    申请日：2012-12-21

    Applicant: Micronit Microfluidics B.V.

    Inventor： Ronny Van 'T Oever ,  Marko Theodoor Blom ,  Jeroen Haneveld ,  Johannes Oonk ,  Marinus Bernardus Olde Riekerink ,  Peter Tijssen ,  Hendrik Jan Hildebrand Tigelaar ,  Jean-Noël Fehr ,  Jean-Christophe Roulet ,  Amitava Gupta

    IPC: B81C1/00 ,  C23F1/02

    CPC classification number: B81C1/00269 ,  B81B2201/058 ,  B81C3/001 ,  B81C2201/0132 ,  B81C2203/0118 ,  B81C2203/019 ,  C23F1/02 ,  H01L21/50 ,  H01L23/10 ,  H01L2924/0002 ,  Y10T428/239 ,  H01L2924/00

    Abstract: The invention relates to method for bonding at least two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, by using an intermediate thin film metal layer for providing the bonding, said method comprising the following steps of: a) providing said two substrates; b) depositing said thin film metal layer on at least a part of a surface of a first substrate of the two substrates; c) bringing a surface of the second substrate into contact with said thin film metal layer on said surface of the first substrate such that a bonding between the second substrate and the thin film metal layer on the first substrate is provided; and d) at least locally strengthening the bonding between the second substrate and the thin film metal layer on the first substrate. The invention also relates to a device comprising two substrates, for example made from glass, silicon, ceramic, aluminum, or boron, and an intermediate thin film metal layer.

    Abstract translation: 本发明涉及通过使用用于提供接合的中间薄膜金属层将至少两个基板（例如由玻璃，硅，陶瓷，铝或硼制成）接合的方法，所述方法包括以下步骤：a） 提供所述两个基板; b）将所述薄膜金属层沉积在所述两个基板的第一基板的表面的至少一部分上; c）使所述第二基板的表面与所述第一基板的所述表面上的所述薄膜金属层接触，从而提供所述第二基板和所述第一基板上的所述薄膜金属层之间的接合; 以及d）至少局部加强第一基板上的第二基板和薄膜金属层之间的接合。 本发明还涉及包括例如由玻璃，硅，陶瓷，铝或硼制成的两个基底和中间薄膜金属层的器件。

    MICROMIXING CHAMBER, MICROMIXER COMPRISING A PLURALITY OF SUCH MICROMIXING CHAMBERS, METHODS FOR MANUFACTURING THEREOF, AND METHODS FOR MIXING
    18.
    发明申请
    MICROMIXING CHAMBER, MICROMIXER COMPRISING A PLURALITY OF SUCH MICROMIXING CHAMBERS, METHODS FOR MANUFACTURING THEREOF, AND METHODS FOR MIXING 审中-公开
    MICROMIXING CHAMBER，MICROMIXER包含这样的微型混合器的多样性，其制造方法和混合方法

    公开(公告)号：WO2008056975A1

    公开(公告)日：2008-05-15

    申请号：PCT/NL2007/000276

    申请日：2007-11-05

    Applicant: MICRONIT MICROFLUIDICS B.V. ,  BLOM, Marko, Theodoor ,  MULDER, Michaël, Christiaan ,  MACLEOD MACINNES, Jordan ,  ALLEN, Raymond, William, Kenneth

    Inventor： BLOM, Marko, Theodoor ,  MULDER, Michaël, Christiaan ,  MACLEOD MACINNES, Jordan ,  ALLEN, Raymond, William, Kenneth

    IPC: B01F5/00 ,  B01F13/00 ,  B01F5/06

    CPC classification number: B01F13/0064 ,  B01F5/0057 ,  B01F5/0646 ,  B01F5/0652 ,  Y10T29/49826

    Abstract: Micromixing chamber, roughly in the form of an hourglass which is provided at a first outer end with a tangential inflow opening (3a, 3c) and at a second outer end with a tangential outflow opening (5a, 5d), which mixing chamber in the overall flow direction first narrows more or less gradually and subsequently widens more or less abruptly. Also micromixer comprising a plurality of such micromixing chambers connected fluidically in series. Also methods for manufacturing such a micromixing chamber or such a micromixer. Also methods for mixing by means of such a micromixing chamber or by means of such a micromixer. A circulating flow in the form of a helix is formed in such a micromixing chamber. A circulating movement forming the beginning of the helix is created in a first part. The circulating movement is gradually accelerated by the more or less gradual narrowing. The gradualness is important in keeping the overall pressure drop over the micromixing chamber within limits. A more or less abrupt widening of the rapidly rotating helix then takes place which is found to provide an additionally good mixing. It is thus found possible to achieve a very efficient and rapid mixing. A micromixing chamber or micromixer according to the invention compatible with known microfluidic devices can be manufactured here from materials usual for the purpose, such as glass, preferably by means of techniques usual in the relevant field, such as powder blasting, etching and bonding.

    Abstract translation: 微混合室大致呈沙漏形式，其设置在具有切向流入开口（3a，3c）的第一外端处，并且在第二外端处具有切向流出开口（5a，5d），所述混合室在 整个流动方向首先逐渐变窄或逐渐变窄，并随后或多或少突然变宽。 还包括微流体混合器，其包括串联连接的多个这样的微混合室。 也是用于制造这种微混合室或这种微混合器的方法。 也是通过这种微混合室或借助于这种微混合器进行混合的方法。 在这样的微混合室中形成螺旋形式的循环流。 在第一部分中产生形成螺旋形开始的循环运动。 循环运动逐渐加速，逐渐变窄。 在微量混合室内的整体压降保持在极限范围内，渐变性很重要。 然后发生快速旋转的螺旋的或多或少突然变宽，这被发现提供另外良好的混合。 因此发现可以实现非常有效和快速的混合。 根据本发明的与已知的微流体装置兼容的微混合室或微混合器可以由本文通常用于目的的材料制成，例如玻璃，优选地通过相关领域通常的技术，例如粉末喷射，蚀刻和粘合。

    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM
    19.
    发明申请
    DEVICE AND METHOD FOR MEASURING A VOLUME OF A LIQUID AND METHOD AND DEVICE FOR CALIBRATING A LIQUID DISPENSING SYSTEM 审中-公开
    用于测量液体体积的装置和方法以及用于校准液体分配系统的方法和装置

    公开(公告)号：WO2015099532A1

    公开(公告)日：2015-07-02

    申请号：PCT/NL2014/050905

    申请日：2014-12-24

    Applicant: MICRONIT MICROFLUIDICS B.V.

    Inventor： VAN 'T OEVER, Ronny ,  BLOM, Marko Theodoor ,  NUTMA, Adriaan Johannes ,  BLOK, Herman Jacobus

    IPC: G01F13/00 ,  G01B13/00 ,  G01B11/00 ,  G01N33/49

    CPC classification number: G01F25/0007 ,  G01B13/00 ,  G01F13/00 ,  G01F25/0092

    Abstract: The invention relates to a device for measuring a volume of a liquid, said device comprising: - a receptacle for receiving said liquid, said receptacle comprising an inlet opening and an outlet opening, and - a capillary channel having capillary action, which capillary channel has a predetermined internal transverse cross-section, wherein an inlet opening of the capillary channel at an first end thereof is in liquid through flow connection with the outlet opening of the receptacle and wherein the other, second end of the capillary channel comprises an opening; wherein: - the inlet opening of the receptacle has a larger transverse cross-section than the inlet opening of said capillary channel, and - a length of a liquid slug in the capillary channel is a measure for said volume. The invention further relates to a method for measuring a volume of a liquid using such a device, a method for calibrating a liquid dispensing system using such a device, a calibrating system for calibrating a liquid dispensing system using such a device and a support for supporting a plurality of such devices.

    Abstract translation: 本发明涉及一种用于测量液体体积的装置，所述装置包括： - 容纳所述液体的容器，所述容器包括入口和出口，以及具有毛细管作用的毛细通道，所述毛细通道具有 预定的内部横截面，其中在其第一端处的毛细通道的入口通过与所述容器的出口开口的流动连接处于液体中，并且其中所述毛细通道的另一个第二端包括开口; 其中： - 所述容器的入口开口具有比所述毛细通道的入口更大的横截面，以及 - 所述毛细通道中的液体段的长度是所述体积的量度。 本发明还涉及使用这种装置测量液体体积的方法，使用这种装置校准液体分配系统的方法，使用这种装置校准液体分配系统的校准系统和用于支撑 多个这样的设备。

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