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公开(公告)号：KR1020030088749A
公开(公告)日：2003-11-20
申请号：KR1020020026615
申请日：2002-05-15
Applicant: (주)케비젠
IPC: C12P19/02
Abstract: PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.
Abstract translation: 目的：提供通过阿拉伯糖异构酶固定生产塔格糖的方法。 通过长时间维持酶活性，塔提糖便宜而有效地批量生产。 构成：通过阿拉伯糖异构酶的固定制备塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，用戊二醛桥接阿拉伯糖异构酶以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 树脂是藻酸钠，氧化铝或二氧化硅; 通过将1.5〜4.0％的藻酸钠溶于水中使用藻酸钠; 通过将60〜70％的氧化铝溶解在50mM tris缓冲溶液中来使用氧化铝; 通过将60〜70％的二氧化硅溶解在50mM tris缓冲溶液中来使用二氧化硅; 底物是半乳糖; 通过将45至55％的半乳糖溶解在pH7至8 tris缓冲溶液中来使用半乳糖; 反应温度为55〜65℃。 C。
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公开(公告)号：KR1020030075213A
公开(公告)日：2003-09-26
申请号：KR1020020014263
申请日：2002-03-16
Applicant: (주)케비젠
IPC: A61K9/50
CPC classification number: A61K9/7007 , A61K9/5021
Abstract: PURPOSE: A process of preparing a water-soluble film having a high solid content, a low viscosity at wide pH range and excellent dispersion stability without causing solidification is provided. Therefore, the film has excellent dispersion stability and prevents the anticancer substances from being released fast after the destruction of the resin film and is thus effectively used in controlled released drug delivery systems, skin absorbing agents, patch agents or the like. CONSTITUTION: A water-soluble film(1) is prepared by: forming a microcapsule by coating anticancer substances(3) with aminoaldehyde polycondensated resin; and then coating the microcapsule with a water-soluble polymer.
Abstract translation: 目的：提供固体成分高，在宽pH范围内的低粘度，优异的分散稳定性而不引起凝固的水溶性薄膜的制造方法。 因此，该膜具有优异的分散稳定性，并且防止了抗癌物质在树脂膜破坏之后快速释放，因此有效地用于受控释放的药物递送系统，皮肤吸收剂，贴剂等中。 构成：通过以下方法制备水溶性薄膜（1）：通过用氨基醛缩聚树脂涂覆抗癌物质（3）形成微胶囊; 然后用水溶性聚合物涂布微胶囊。
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公开(公告)号：KR1020020060598A
公开(公告)日：2002-07-18
申请号：KR1020020001178
申请日：2002-01-09
Applicant: (주)케비젠
IPC: C07K5/00
CPC classification number: C07C403/08 , A23L33/155 , A61K8/671 , A61K31/07 , A61Q5/02 , A61Q19/005 , A61Q19/008 , A61Q19/10 , C07K5/04 , C07K19/00
Abstract: PURPOSE: Provided are a novel retinol derivative, its preparation method in higher yield, and its use. The novel retinol has excellent light-stability, and shows high reactivity to retinoic acid receptor α, while showing low reactivity to retinoic receptor β and γ. It can applied to medical products, cosmetics, soap, shampoo, functional foods, etc., for the prevention and improvement of skin aging. CONSTITUTION: The novel retinol derivative is characterized by carboester bond of a peptide material having COOH group, wherein the peptide material having COOH group is selected from -di, -tri, -poly peptide including N-L- α-aspartyl-L-phenylalanine 1-methylester(AMP;aspartame), N-protection group-aspartame, neotame and the like. Its manufacturing method comprises the steps of: reacting retinylacetate with methanolic solvent and inorganic slat at 25-40 deg.C in a dark room then extracting the reaction product with ether solvent; removing the solvent then followed by mixing a compound having OH group, natural or separated and purified retinol, diethylazodicarboxylate and triphenylphosphate with methylenechloride solvent, and reacting them at room temperature to obtain the ester derivative of retinol; and performing chromatography with reverse-phase, Merck Silicagel 60 RP 18(40-63) micro meter to separate pure ester derivative of retinol.
Abstract translation: 目的：提供一种新型视黄醇衍生物，其制备方法较高产率及其用途。 该新型视黄醇具有优异的光稳定性，对视黄酸受体α具有高反应性，而对视黄酸受体β和γ的反应性低。 适用于医疗用品，化妆品，肥皂，洗发水，功能性食品等，用于预防和改善皮肤老化。 构成：新型视黄醇衍生物的特征在于具有COOH基团的肽材料的碳键，其中具有COOH基团的肽材料选自-di，-tri， - 多肽，包括NL-α-天冬氨酰-L-苯丙氨酸1- 甲基酯（AMP;阿斯巴甜），N-保护基 - 阿斯巴甜，neotame等。 其制造方法包括以下步骤：将黑醋酸乙烯酯与甲醇溶剂和无机条板在25-40℃下在暗室中反应，然后用乙醚溶剂萃取反应产物; 除去溶剂，然后将具有OH基团的化合物，天然或分离的纯化的视黄醇，偶氮二甲酸二乙酯和磷酸三苯酯与二氯甲烷溶剂混合，并在室温下使其反应，得到视黄醇的酯衍生物; 并用反相色谱法，Merck Silicagel 60 RP 18（40-63）微米分离纯化的视黄醇酯衍生物。
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公开(公告)号：KR100548058B1
公开(公告)日：2006-01-31
申请号：KR1020020066071
申请日：2002-10-29
Applicant: (주)케비젠
IPC: A61K36/488 , A61P35/00
Abstract: 본 발명은 퓨에라리아 속 식물 뿌리의 알콜 추출물을 함유하는 항암용 조성물에 관한 것으로, 항암 효과가 뛰어나며 부작용이 적어 각종 암의 예방과 치료에 유용하게 사용될 수 있다.
또한, 본 발명의 퓨에라리아 속 식물 뿌리의 알콜 추출물은 피부에 안정할 뿐 아니라, 보습효과, 피부 탄력 효과, 잔주름, 기미, 잡티 등의 예방에 효과적이므로, 화장료 조성물로 유용하게 사용될 수 있다.Abstract translation: 本发明涉及含有pyuerariah的在植物根部的醇提取物的抗癌组合物，以及优良的抗肿瘤活性具有副作用少，可以是各种癌症的预防和治疗是有用的。
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Patent Agency Ranking
公开(公告)号：KR100516378B1
公开(公告)日：2005-09-26
申请号：KR1020050014553
申请日：2005-02-22
Applicant: (주)케비젠
Abstract: 본 발명은 퓨에라리아 속 식물 뿌리의 알콜 추출물을 함유하는 항암용 조성물에 관한 것으로, 항암 효과가 뛰어나며 부작용이 적어 각종 암의 예방과 치료에 유용하게 사용될 수 있다.
또한, 본 발명의 퓨에라리아 속 식물 뿌리의 알콜 추출물은 피부에 안정할 뿐 아니라, 보습효과, 피부 탄력 효과, 잔주름, 기미, 잡티 등의 예방에 효과적이므로, 화장료 조성물로 유용하게 사용될 수 있다.-
16.发明授权
公开(公告)号：KR100514592B1
公开(公告)日：2005-09-13
申请号：KR1020050004127
申请日：2005-01-17
Applicant: (주)케비젠
IPC: C12N1/20
CPC classification number: C12P7/6427 , A23C9/1234 , A23C11/106 , A23L33/12 , A23L33/135 , A23P10/30 , A23Y2300/59 , A61K35/744 , A61K35/745 , C12R1/13
Abstract: 본 발명은 공역화 리놀레인산(CLA)을 생산할 수 있는 신규한 균주에 관한 것이다.
본 발명의 균주에는 비피도박테리움 브레베(
Bifidobacterium breve ) CBG-C2 균주, 비피도박테리움 슈도카르테눌라툼(
Bifidobacterium pseudocartenulatum ) CBG-C4 균주 및 엔테로코커스 패시움(
Enterococcus faecium ) CBG-C5 균주가 포함된다.
본 발명의 균주는 CLA 생산 능력이 우수하며, CLA를 생성하여 배지로 분비하는 한편 균체 내에 축적할 수 있다. 또한 본 발명의 균주는 위산이나 담즙 등의 산과 항생물질에 대해 강한 내성을 지닌다.
본 발명의 균주를 포함하는 조성물은 수용성 다당류로 이루어진 피복물질 내에 본 발명의 균주와 CLA를 포함하는 캡슐제 형태로 제조되어, 기능성 식품 및 의약품으로 사용될 수 있다.-
17.发明公开공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품 有权生产微生物的共轭亚油酸（CLA），其将CLA分解成生物质中的中和和累积物，包含其的包封组合物和使用其的功能性食品
公开(公告)号：KR1020050023364A
公开(公告)日：2005-03-09
申请号：KR1020050004128
申请日：2005-01-17
Applicant: (주)케비젠
IPC: C12N1/20
CPC classification number: C12P7/6427 , A23C9/1234 , A23C11/106 , A23L33/12 , A23L33/135 , A23P10/30 , A23Y2300/59 , A61K35/744 , A61K35/745 , C12R1/13
Abstract: PURPOSE: Provided are a conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Enterococcus faecium CBG-C5(KACC 91002). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism Enterococcus faecium CBG-C5(KACC 91002), wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).
Abstract translation: 目的：提供共轭亚油酸（CLA）生产微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）产生活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是屎肠球菌CBG-C5（KACC91002）。 用于预防和治疗癌症，动脉硬化，糖尿病和软绵绵的包封组合物包括CLA产生微生物屎肠球菌CBG-C5（KACC91002），其中涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。
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公开(公告)号：KR1020020090850A
公开(公告)日：2002-12-05
申请号：KR1020020015016
申请日：2002-03-20
Applicant: (주)케비젠
IPC: C07C235/78
Abstract: PURPOSE: A novel retinoid derivative, its preparation method, a compound used for preparing the derivative, and an anticancer medicine composition containing the derivative are provided, which retinoid derivative shows the excellent anticancer activity and no toxic side effect. CONSTITUTION: The retinoid derivative is represented by the formula I, wherein R¬1 and R¬2 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, -RCO(CH2)mCHCH3CH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬3 is H; R¬1 and R¬3 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬2 is H; R¬1 is OH, SH, NH2, COOH, -R(CH2)mCH3, R¬2 is H, and R¬3 is H, OH or Cl; R¬3 is OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, R¬2 is H, and R¬1 is H, OH or Cl; or R¬1, R¬2 and R¬3 are independent each another and are OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2; and R is CH2, O, NH or S, R¬4 is H or an alkyl group of C1-C6, and m is an integer of 0-5.
Abstract translation: 目的：提供一种新型类视黄醇衍生物及其制备方法，用于制备衍生物的化合物和含有该衍生物的抗癌药物组合物，其视黄酸衍生物显示出优异的抗癌活性，无毒副作用。 构型：类视黄醇衍生物由式I表示，其中R 1和R 2彼此独立，为OH，SH，NH 2，COOH，-R（CH 2）m CH 3，-RCOCO（CH 2）m CH 3，-RCO （CH 2）m CHCH 3 CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 3 3是H; R 1和R 3彼此独立地是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，-OCOO（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 12是H; R 1是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，R 2是H，R 3是H，OH或Cl; R 3是OH，SH，NH 2，COOH，-R（CH 2）m CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 2是H，R 1是H，OH或Cl; 或R 1，R 2和R 3彼此独立，并且是OH，SH，NH 2，COOH，-R（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2; 且R为CH 2，O，NH或S，R 4为H或C 1 -C 6烷基，m为0-5的整数。
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公开(公告)号：KR1020020085491A
公开(公告)日：2002-11-16
申请号：KR1020010025012
申请日：2001-05-08
IPC: C07C227/18
Abstract: PURPOSE: A novel method for preparing α-L-aspartyl-L-phenylalanine methyl ester·HCl salt is provided, to reduce the amount of by-products, to allow the by-products to be reused after hydrolysis and to increase the production yield by 20% or more. CONSTITUTION: The method comprises the steps of reacting L-aspartic acid with trimethyl silyl chloride in the presence of an alcohol solvent to esterify the β-COOH selectively to obtain α-L-aspartyl-L-phenylalanine methyl ester·HCl. Preferably the alcohol solvent is selected from the group consisting of methyl alcohol, ethyl alcohol, allyl alcohol and benzyl alcohol. Preferably the method comprises further the steps of protecting an amine group with -CHO, Boc, benzyloxycarbonyl group, or -C(O)OR¬2 (R2 is methyl. ethyl or isobutyl group) by using acetic anhydride and formic acid.
Abstract translation: 目的：提供一种制备α-L-天冬氨酰-L-苯丙氨酸甲酯·HCl盐的新方法，以减少副产物的含量，使副产物在水解后再次使用，并提高产量 减少20％以上。 方法：该方法包括在醇溶剂存在下使L-天冬氨酸与三甲基甲硅烷基氯反应，选择性地酯化β-COOH，得到α-L-天冬氨酰-L-苯丙氨酸甲酯·HCl。 醇溶剂优选选自甲醇，乙醇，烯丙醇和苄醇。 优选地，所述方法还包括通过使用乙酸酐和甲酸保护具有-CHO，Boc，苄氧基羰基或-C（O）OR 2（R2为甲基，乙基或异丁基）的胺基的步骤。
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