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    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물
    1.
    发明公开
    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물 有权
    含有衍生物的新型复方衍生物，制剂方法和抗癌药物组合物

    公开(公告)号：KR1020020090850A

    公开(公告)日：2002-12-05

    申请号：KR1020020015016

    申请日：2002-03-20

    Applicant: (주)케비젠

    Inventor： 신홍식 ,  엄수종 ,  노영쇠 ,  박시호 ,  권윤자 ,  박명순 ,  한혜숙 ,  김소미 ,  김동명 ,  오덕근 ,  박종섭 ,  배태성

    IPC: C07C235/78

    Abstract: PURPOSE: A novel retinoid derivative, its preparation method, a compound used for preparing the derivative, and an anticancer medicine composition containing the derivative are provided, which retinoid derivative shows the excellent anticancer activity and no toxic side effect. CONSTITUTION: The retinoid derivative is represented by the formula I, wherein R¬1 and R¬2 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, -RCO(CH2)mCHCH3CH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬3 is H; R¬1 and R¬3 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬2 is H; R¬1 is OH, SH, NH2, COOH, -R(CH2)mCH3, R¬2 is H, and R¬3 is H, OH or Cl; R¬3 is OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, R¬2 is H, and R¬1 is H, OH or Cl; or R¬1, R¬2 and R¬3 are independent each another and are OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2; and R is CH2, O, NH or S, R¬4 is H or an alkyl group of C1-C6, and m is an integer of 0-5.

    Abstract translation: 目的：提供一种新型类视黄醇衍生物及其制备方法，用于制备衍生物的化合物和含有该衍生物的抗癌药物组合物，其视黄酸衍生物显示出优异的抗癌活性，无毒副作用。 构型：类视黄醇衍生物由式I表示，其中R 1和R 2彼此独立，为OH，SH，NH 2，COOH，-R（CH 2）m CH 3，-RCOCO（CH 2）m CH 3，-RCO （CH 2）m CHCH 3 CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 3 3是H; R 1和R 3彼此独立地是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，-OCOO（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 12是H; R 1是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，R 2是H，R 3是H，OH或Cl; R 3是OH，SH，NH 2，COOH，-R（CH 2）m CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 2是H，R 1是H，OH或Cl; 或R 1，R 2和R 3彼此独立，并且是OH，SH，NH 2，COOH，-R（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2; 且R为CH 2，O，NH或S，R 4为H或C 1 -C 6烷基，m为0-5的整数。

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