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    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품
    13.
    发明公开
    공역화 리놀렌산을 생산하는 신규한 균주, 이를 함유하는 캡슐제 및 이를 이용한 기능성 식품 有权
    生产微生物的共轭亚油酸（CLA），其将CLA分解成生物质中的中和和累积物，包含其的包封组合物和使用其的功能性食品

    公开(公告)号：KR1020050023364A

    公开(公告)日：2005-03-09

    申请号：KR1020050004128

    申请日：2005-01-17

    Applicant: (주)케비젠

    Inventor： 김소미 ,  오덕근 ,  백대헌 ,  신홍식 ,  박시호 ,  이유진 ,  엄수종 ,  노영쇠 ,  박종섭

    IPC: C12N1/20

    CPC classification number: C12P7/6427 ,  A23C9/1234 ,  A23C11/106 ,  A23L33/12 ,  A23L33/135 ,  A23P10/30 ,  A23Y2300/59 ,  A61K35/744 ,  A61K35/745 ,  C12R1/13

    Abstract: PURPOSE: Provided are a conjugated linoleic acid(CLA) producing microorganism, a capsulated composition comprising the same microorganism, and the functional food using the same composition, which microorganism has improved conjugated linoleic acid(CLA) producing activity, secretes CLA into the medium and accumulates CLA within the biomass, and has tolerance against acids such as acid in the stomach and bile juice and antibiotics. CONSTITUTION: The CLA producing microorganism which converts linoleic acid(LA) into conjugated linoleic acid(CLA) is provided, wherein the CLA producing microorganism is Enterococcus faecium CBG-C5(KACC 91002). The capsulated composition for prevention and treatment of cancer, arteriosclerosis, diabetes and obeseness comprises the CLA producing microorganism Enterococcus faecium CBG-C5(KACC 91002), wherein the coating material is water-soluble polysaccharides. The functional food containing the capsulated composition is provided, wherein the food is yoghurt, cheese, kimchi and jang(fermented soybean).

    Abstract translation: 目的：提供共轭亚油酸（CLA）生产微生物，包含相同微生物的包封组合物和使用相同组成的功能性食品，该微生物具有改善的共轭亚油酸（CLA）产生活性，将CLA分泌到培养基中， 在生物质内积累CLA，并且具有对胃酸，胆汁和抗生素等酸的耐受性。 构成：提供将亚油酸（LA）转化为共轭亚油酸（CLA）的CLA产生微生物，其中CLA产生微生物是屎肠球菌CBG-C5（KACC91002）。 用于预防和治疗癌症，动脉硬化，糖尿病和软绵绵的包封组合物包括CLA产生微生物屎肠球菌CBG-C5（KACC91002），其中涂层材料是水溶性多糖。 提供含有封装组合物的功能性食品，其中食品是酸奶，奶酪，泡菜和姜（发酵大豆）。

    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물
    14.
    发明公开
    신규한 레티노이드 유도체 및 이의 제조방법 및 그화합물을 함유한 항암제 조성물 有权
    含有衍生物的新型复方衍生物，制剂方法和抗癌药物组合物

    公开(公告)号：KR1020020090850A

    公开(公告)日：2002-12-05

    申请号：KR1020020015016

    申请日：2002-03-20

    Applicant: (주)케비젠

    Inventor： 신홍식 ,  엄수종 ,  노영쇠 ,  박시호 ,  권윤자 ,  박명순 ,  한혜숙 ,  김소미 ,  김동명 ,  오덕근 ,  박종섭 ,  배태성

    IPC: C07C235/78

    Abstract: PURPOSE: A novel retinoid derivative, its preparation method, a compound used for preparing the derivative, and an anticancer medicine composition containing the derivative are provided, which retinoid derivative shows the excellent anticancer activity and no toxic side effect. CONSTITUTION: The retinoid derivative is represented by the formula I, wherein R¬1 and R¬2 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, -RCO(CH2)mCHCH3CH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬3 is H; R¬1 and R¬3 are independent each other and are OH, SH, NH2, COOH, -R(CH2)mCH3, -RCOCO(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, and R¬2 is H; R¬1 is OH, SH, NH2, COOH, -R(CH2)mCH3, R¬2 is H, and R¬3 is H, OH or Cl; R¬3 is OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2, R¬2 is H, and R¬1 is H, OH or Cl; or R¬1, R¬2 and R¬3 are independent each another and are OH, SH, NH2, COOH, -R(CH2)mCH3, or -RCOCH(NCOCH3)CH2CH2CONH2; and R is CH2, O, NH or S, R¬4 is H or an alkyl group of C1-C6, and m is an integer of 0-5.

    Abstract translation: 目的：提供一种新型类视黄醇衍生物及其制备方法，用于制备衍生物的化合物和含有该衍生物的抗癌药物组合物，其视黄酸衍生物显示出优异的抗癌活性，无毒副作用。 构型：类视黄醇衍生物由式I表示，其中R 1和R 2彼此独立，为OH，SH，NH 2，COOH，-R（CH 2）m CH 3，-RCOCO（CH 2）m CH 3，-RCO （CH 2）m CHCH 3 CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 3 3是H; R 1和R 3彼此独立地是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，-OCOO（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 12是H; R 1是OH，SH，NH 2，COOH，-R（CH 2）mCH 3，R 2是H，R 3是H，OH或Cl; R 3是OH，SH，NH 2，COOH，-R（CH 2）m CH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2，R 2是H，R 1是H，OH或Cl; 或R 1，R 2和R 3彼此独立，并且是OH，SH，NH 2，COOH，-R（CH 2）mCH 3或-RCOCH（NCOCH 3）CH 2 CH 2 CONH 2; 且R为CH 2，O，NH或S，R 4为H或C 1 -C 6烷基，m为0-5的整数。

    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법
    17.
    发明授权
    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법 有权
    아라비노스이성화효소의고정화에의한타가토스의생산방

    公开(公告)号：KR100464061B1

    公开(公告)日：2004-12-30

    申请号：KR1020020026615

    申请日：2002-05-15

    Applicant: (주)케비젠

    Inventor： 오덕근 ,  김소미 ,  신홍식 ,  엄수종 ,  노영쇠 ,  박종섭 ,  김동명 ,  박시호

    IPC: C12P19/02

    Abstract: PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.

    Abstract translation: 目的：提供一种通过固定阿拉伯糖异构酶来生产塔格糖的方法。 塔格糖通过长期维持酶活性而廉价且有效地大量生产。 构成：通过固定阿拉伯糖异构酶生产塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，将阿拉伯糖异构酶与戊二醛桥接以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 该树脂是海藻酸钠，氧化铝或二氧化硅; 海藻酸钠通过在水中溶解1.5至4.0％的海藻酸钠来使用; 通过在50mM tris缓冲溶液中溶解60-70％的氧化铝来使用氧化铝; 二氧化硅是通过将60-70％的二氧化硅溶解在50mM tris缓冲溶液中而使用的; 底物是半乳糖; 半乳糖通过在pH 7至8 Tris缓冲溶液中溶解45-55％半乳糖来使用; 反应温度为55〜65℃。 C。

    신규한 레티놀 유도체, 그 제조방법 및 그 용도
    18.
    发明授权
    신규한 레티놀 유도체, 그 제조방법 및 그 용도 有权
    신규한레티놀유도체，그제조방법및그용도

    公开(公告)号：KR100437102B1

    公开(公告)日：2004-06-23

    申请号：KR1020020001178

    申请日：2002-01-09

    Applicant: (주)케비젠

    Inventor： 신홍식 ,  박시호 ,  노영쇠 ,  엄수종 ,  권윤자 ,  박명순 ,  한혜숙 ,  정민숙 ,  김소미 ,  김동명 ,  오덕근 ,  박종섭

    IPC: C07K5/00

    Abstract: PURPOSE: Provided are a novel retinol derivative, its preparation method in higher yield, and its use. The novel retinol has excellent light-stability, and shows high reactivity to retinoic acid receptor α, while showing low reactivity to retinoic receptor β and γ. It can applied to medical products, cosmetics, soap, shampoo, functional foods, etc., for the prevention and improvement of skin aging. CONSTITUTION: The novel retinol derivative is characterized by carboester bond of a peptide material having COOH group, wherein the peptide material having COOH group is selected from -di, -tri, -poly peptide including N-L- α-aspartyl-L-phenylalanine 1-methylester(AMP;aspartame), N-protection group-aspartame, neotame and the like. Its manufacturing method comprises the steps of: reacting retinylacetate with methanolic solvent and inorganic slat at 25-40 deg.C in a dark room then extracting the reaction product with ether solvent; removing the solvent then followed by mixing a compound having OH group, natural or separated and purified retinol, diethylazodicarboxylate and triphenylphosphate with methylenechloride solvent, and reacting them at room temperature to obtain the ester derivative of retinol; and performing chromatography with reverse-phase, Merck Silicagel 60 RP 18(40-63) micro meter to separate pure ester derivative of retinol.

    Abstract translation: 目的：提供一种新颖的视黄醇衍生物及其制备方法，其收率较高，并且其用途。 该新型视黄醇具有优异的光稳定性，并且对视黄酸受体α具有高反应性，而对视黄酸受体β具有低反应性; 和＆amp; gamma ;. 它可以应用于医疗产品，化妆品，肥皂，洗发水，功能性食品等，以预防和改善皮肤老化。 构成：新颖的视黄醇衍生物的特征在于具有COOH基团的肽材料的羧基酯键，其中具有COOH基团的肽材料选自包括NL-和α-天冬氨酰-L- 苯丙氨酸1-甲酯（AMP;天冬甜素），N-保护基 - 阿斯巴甜，纽甜等。 其制造方法包括以下步骤：在25-40℃，在黑暗的房间内将乙酸视黄醇酯与甲醇溶剂和无机薄片反应，然后用乙醚溶剂萃取反应产物; 然后除去溶剂，然后将具有OH基团的化合物，天然或分离纯化的视黄醇，偶氮二羧酸二乙酯和磷酸三苯酯与二氯甲烷溶剂混合，并在室温下反应，得到视黄醇的酯衍生物; 并用反相色谱（Merck Silicagel 60 RP 18（40-63）微米）进行色谱分离以分离视黄醇的纯酯衍生物。

    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법
    19.
    发明公开
    아라비노스 이성화효소의 고정화에 의한 타가토스의 생산방법 有权
    通过阿拉伯糖异构酶的固定生产标签的方法

    公开(公告)号：KR1020030088749A

    公开(公告)日：2003-11-20

    申请号：KR1020020026615

    申请日：2002-05-15

    Applicant: (주)케비젠

    Inventor： 오덕근 ,  김소미 ,  신홍식 ,  엄수종 ,  노영쇠 ,  박종섭 ,  김동명 ,  박시호

    IPC: C12P19/02

    Abstract: PURPOSE: A method for producing tagatose by immobilization of arabinose isomerase is provided. Tagatose is cheaply and effectively mass-produced by maintaining the enzyme activity for a long time. CONSTITUTION: A method for producing tagatose by immobilization of arabinose isomerase comprises binding arabinose isomerase to resin, bridging arabinose isomerase with glutaraldehyde to immobilize the arabinose isomerase, and reacting the immobilized arabinose isomerase with substrate, wherein the concentration of arabinose isomerase is 10 mg/ml; the resin is sodium alginate, alumina or silica; the sodium alginate is used by dissolving 1.5 to 4.0% of sodium alginate in water; the alumina is used by dissolving 60 to 70% of alumina in 50 mM tris buffer solution; the silica is used by dissolving 60 to 70% of silica in 50 mM tris buffer solution; substrate is galactose; the galactose is used by dissolving 45 to 55% of galactose in pH 7 to 8 tris buffer solution; and the reaction temperature is 55 to 65 deg. C.

    Abstract translation: 目的：提供通过阿拉伯糖异构酶固定生产塔格糖的方法。 通过长时间维持酶活性，塔提糖便宜而有效地批量生产。 构成：通过阿拉伯糖异构酶的固定制备塔格糖的方法包括将阿拉伯糖异构酶与树脂结合，用戊二醛桥接阿拉伯糖异构酶以固定阿拉伯糖异构酶，并使固定的阿拉伯糖异构酶与底物反应，其中阿拉伯糖异构酶的浓度为10mg / ml ; 树脂是藻酸钠，氧化铝或二氧化硅; 通过将1.5〜4.0％的藻酸钠溶于水中使用藻酸钠; 通过将60〜70％的氧化铝溶解在50mM tris缓冲溶液中来使用氧化铝; 通过将60〜70％的二氧化硅溶解在50mM tris缓冲溶液中来使用二氧化硅; 底物是半乳糖; 通过将45至55％的半乳糖溶解在pH7至8 tris缓冲溶液中来使用半乳糖; 反应温度为55〜65℃。 C。

    항암물질을 함유하는 수용성 필름제 및 이의 제조방법
    20.
    发明公开
    항암물질을 함유하는 수용성 필름제 및 이의 제조방법 无效
    含有防腐剂物质的水溶性膜及其生产

    公开(公告)号：KR1020030075213A

    公开(公告)日：2003-09-26

    申请号：KR1020020014263

    申请日：2002-03-16

    Applicant: (주)케비젠

    Inventor： 김동명 ,  박종섭 ,  김소미 ,  노영쇠 ,  박시호 ,  신홍식 ,  엄수종 ,  오덕근

    IPC: A61K9/50

    CPC classification number: A61K9/7007 ,  A61K9/5021

    Abstract: PURPOSE: A process of preparing a water-soluble film having a high solid content, a low viscosity at wide pH range and excellent dispersion stability without causing solidification is provided. Therefore, the film has excellent dispersion stability and prevents the anticancer substances from being released fast after the destruction of the resin film and is thus effectively used in controlled released drug delivery systems, skin absorbing agents, patch agents or the like. CONSTITUTION: A water-soluble film(1) is prepared by: forming a microcapsule by coating anticancer substances(3) with aminoaldehyde polycondensated resin; and then coating the microcapsule with a water-soluble polymer.

    Abstract translation: 目的：提供固体成分高，在宽pH范围内的低粘度，优异的分散稳定性而不引起凝固的水溶性薄膜的制造方法。 因此，该膜具有优异的分散稳定性，并且防止了抗癌物质在树脂膜破坏之后快速释放，因此有效地用于受控释放的药物递送系统，皮肤吸收剂，贴剂等中。 构成：通过以下方法制备水溶性薄膜（1）：通过用氨基醛缩聚树脂涂覆抗癌物质（3）形成微胶囊; 然后用水溶性聚合物涂布微胶囊。

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