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公开(公告)号：KR101318031B1
公开(公告)日：2013-10-14
申请号：KR1020110081434
申请日：2011-08-17
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 프로스타글란딘(PGE
2 ), AP-1 및 TNF-α의 발현 및 생성을 억제하도록 하여 항염증 및 면역조절 활성에 효과가 있고, 염증성 및 자가면역성 질환의 예방 및 개선에 효과가 있다. 이를 위해 특히, 수식화된 나노섬유를 이용하는 펩타이드를 포함하는 것을 특징으로 하는 염증성 및 자가면역성 질환의 예방 및 개선용 약학조성물이 개시된다.-
公开(公告)号：KR1020110054448A
公开(公告)日：2011-05-25
申请号：KR1020090111084
申请日：2009-11-17
Applicant: 강원대학교산학협력단
IPC: A61K31/366 , A61P35/00
Abstract: PURPOSE: An anticancer composition containing kojic acid derivative compounds is provided to suppress glioma proliferation and to prevent and treat glioma-derived tumor. CONSTITUTION: An anticancer composition contains kojic acid derivative of chemical formula 1 or 2 as an active ingredient. The compound of chemical formula 1 is 5-hydroxy-2-((2-((5-hydroxy-4-oxo-4H-pyrane-2-yl)methylthio)phenylthio)methyl)-4H-pyrane-4-one. The compound of chemical formula 2 is -(((2-(((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl)sulfanyl)ethyl) sulfanyl)methyl)-4H-pyran-4-one of chemical formula 3 or 5-hydroxy-2-(((2-(((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl)sulfanyl) propyl)sulfanyl)methyl)-4H-pyran-4-one of chemical formula 4.
Abstract translation: 目的：提供含有曲酸衍生物化合物的抗癌组合物，以抑制神经胶质瘤增生并预防和治疗胶质瘤源性肿瘤。 构成：抗癌组合物含有化学式1或2的曲酸衍生物作为活性成分。 化学式1的化合物是5-羟基-2 - （（2 - （（5-羟基-4-氧代-4H-吡喃-2-基）甲硫基）苯硫基）甲基）-4H-吡喃-4-酮。 化学式2的化合物是 - （（2 - （（（5-羟基-4-氧代-4H-吡喃-2-基）甲基）硫烷基）乙基）硫烷基）甲基）-4H-吡喃-4-酮 化学式3或5-羟基-2 - （（2 - （（（5-羟基-4-氧代-4H-吡喃-2-基）甲基）硫烷基）丙基）硫烷基）甲基）-4H-吡喃 - 化学式4的4-one。
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公开(公告)号：KR1020100124054A
公开(公告)日：2010-11-26
申请号：KR1020090043098
申请日：2009-05-18
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61K8/97 , A61P17/04 , A23L1/30
Abstract: PURPOSE: A composition containing Codonopis lanceolata extract or Codonopis lanceolata saponin is provided to prevent or treat diseases or symptom caused by excessive histamine secretion. CONSTITUTION: A composition for suppressing histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. A composition for preventin or treating disease or symptom caused by excessive histamine secretion contains Codonopis lanceolata or Codonopis lanceolata saponin as an active ingredient. The diseases or symptom caused by excessive histamine secretion is pruritus, rhinorrhea, nasal obstruction, idle talk increase, chest pressure feeling, respiratory distress, circulating machine, and hypotension. A pharmaceutical composition for preventing or treating pruritus contains Codonopis lanceolata saponin as an active ingredient.
Abstract translation: 目的：提供含有Codonopis lanceolata提取物或Codonopis lanceolata皂苷的组合物，用于预防或治疗由过量组胺分泌引起的疾病或症状。 构成：用于抑制组胺分泌的组合物含有爪蟾属（Codonopis lanceolata）或爪蟾属（Codonopis lanceolata saponin）作为活性成分。 用于预防或治疗由过度组胺分泌引起的疾病或症状的组合物含有角叉菜（Cloonopis lanceolata）或爪蟾属（Codonopis lanceolata saponin）作为活性成分。 由组胺分泌过多引起的疾病或症状是瘙痒，鼻漏，鼻塞，空闲谈话增加，胸压感，呼吸窘迫，循环机和低血压。 用于预防或治疗瘙痒症的药物组合物含有作为活性成分的角叉菜皂甙皂甙。
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公开(公告)号：KR100954103B1
公开(公告)日：2010-04-23
申请号：KR1020090115946
申请日：2009-11-27
Applicant: 강원대학교산학협력단
Abstract: PURPOSE: A hydroquinone(HQ) derivative having anti-inflammation and immunity properties is provided to reduce NO generation by suppressing PDK1/Akt(protein kinase B) and to treat or prevent inflammation and septic shock. CONSTITUTION: A hydroquinone derivative compound is denoted by chemical formula 1. The hydroquinone derivative compound is 2-Allylbenzene-1,4-diol, (E)-2-(4-Hydroxy-3-methylbut-2-enyl)benzene-1,4-diol, (E)-2-(3-Methylnon-2-enyl)benzene-1,4-diol, (E)-2-(9-Hydroxy-3-methylnon-2-enyl) benzene-1,4-diol, and (E) -2 - (3-Methylhex-2-enyl) benzene-1,4-diol. A composition for preventing or treating septic shock contains the hydroquinone derivative compound of chemical formula 1. A health food for preventing or treating septic shock contains the hydroquinone derivative compound and a sitologically acceptable food supplement.
Abstract translation: 目的：提供具有抗炎和免疫性质的氢醌（HQ）衍生物，通过抑制PDK1 / Akt（蛋白激酶B）和治疗或预防炎症和败血性休克来减少NO产生。 构成：氢醌衍生物化合物由化学式1表示。氢醌衍生物化合物为2-烯丙基苯-1,4-二醇，（E）-2-（4-羟基-3-甲基丁-2-烯基）苯-1 ，（E）-2-（3-甲基壬-2-烯基）苯-1,4-二醇，（E）-2-（9-羟基-3-甲基壬-2-烯基）苯-1 ，4-二醇和（E）-2-（3-甲基己-2-烯基）苯-1,4-二醇。 用于预防或治疗脓毒性休克的组合物含有化学式1的氢醌衍生物化合物。用于预防或治疗败血性休克的保健食品含有氢醌衍生物化合物和可食用的食品补充剂。
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15.发明授权조혈모세포 증식을 갖는 더덕의 부탄올 분획을 함유하는 건강식품 조성물 失效包含丁醇溶液提取物的健康食品的组合物具有HEMATOPOIETIC STEM细胞增殖活性的腐败性土耳其BENTH ET HOOK
公开(公告)号：KR100921909B1
公开(公告)日：2009-10-16
申请号：KR1020080134155
申请日：2008-12-26
Applicant: 강원대학교산학협력단
CPC classification number: A23L2/38 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2200/308 , A23V2200/324 , A23V2250/21
Abstract: PURPOSE: A health food composition containing the butanol fraction of Condonopsis lanceolata is provided to ensure immunological enhancement and anticancer activity. CONSTITUTION: A method for preparing a health food composition containing the butanol fraction of Condonopsis lanceolata comprises the following steps of: extracting Condonopsis lanceolata roots in 5-10 times the amount of hot water and suspending the Condonopsis lanceolata extract in 5-10 times the amount of water; and fraction-extracting it in 5-10 times the amount of hexane, 5-10 times the amount of ethylacetate, and 5-10 times the amount of butanol in sequential order.
Abstract translation: 目的：提供一种保健食品组合物，其中含有黄连杆菌的丁醇馏分，以确保免疫增强和抗癌活性。 构成：一种制备含有堇菜多糖的丁醇馏分的保健食品组合物的方法，包括以下步骤：以5-10倍量的热水提取堇菜根，并将康宁茯苓提取物悬浮5-10倍量 的水; 并以5-10倍量的己烷分数提取5-10倍量乙酸乙酯，按顺序加入5-10倍量的丁醇。
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Patent Agency Ranking
公开(公告)号：KR1020130019472A
公开(公告)日：2013-02-27
申请号：KR1020110081434
申请日：2011-08-17
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/16 , A61K9/06 , A61K38/38 , Y10S514/885 , Y10S514/886
Abstract: PURPOSE: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is provided to suppress expression and generation of PGE2(prostaglandin), AP-1, and TNF-alpha and to prevent and treat the diseases. CONSTITUTION: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is a self-assembly type. The peptide nanofiber includes lysozyme, a trypsin inhibitor, BSA(bovine serum albumin), and IgG protein. The peptide nanofiber contains Acetyl-(Arg-Ala-Asp-Ala)4-CONH2[Ac-(RADA)4-CONH2] peptide hydrogel. The peptide nanofiber suppresses PGE2, AP-1, and TNF-alpha activation.
Abstract translation: 目的：提供用于预防和治疗炎症和自身免疫疾病的肽纳米纤维，以抑制PGE2（前列腺素），AP-1和TNF-α的表达和产生并预防和治疗疾病。 构成：用于预防和治疗炎性和自身免疫性疾病的肽纳米纤维是一种自组装型。 肽纳米纤维包括溶菌酶，胰蛋白酶抑制剂，BSA（牛血清白蛋白）和IgG蛋白。 肽纳米纤维含有乙酰基 - （Arg-Ala-Asp-Ala）4-CONH 2 [Ac-（RADA）4-CONH 2]肽水凝胶。 肽纳米纤维抑制PGE2，AP-1和TNF-α激活。
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17.发明授权
公开(公告)号：KR101141779B1
公开(公告)日：2012-05-03
申请号：KR1020090035529
申请日：2009-04-23
Applicant: 강원대학교산학협력단
IPC: A61K36/344 , A61P17/14 , A23L1/30 , A61K8/97
Abstract: 본 발명은 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 발모 또는 양모 촉진용 조성물 및 이를 포함하는 피부외용제 또는 기능성 식품에 관한 것이다.
본 발명은 또한 더덕 추출물 또는 더덕의 사포닌을 유효성분으로 포함하는 조성물을 사용하여 발모 또는 양모를 촉진하는 방법을 제공한다.
본 발명의 조성물 및 이를 함유하는 제품은 사람 뿐만 아니라 애완동물이나, 털을 채취하거나 모피를 이용하는 동물에 적용할 수 있다.
더덕, 사포닌, 발모, 양모-
公开(公告)号：KR101049041B1
公开(公告)日：2011-07-13
申请号：KR1020110032470
申请日：2011-04-08
Applicant: 강원대학교산학협력단
IPC: A61K36/704 , A61P29/00 , A61P37/00
CPC classification number: A61K36/70 , A23V2200/324 , A61K2236/333 , Y10S514/886
Abstract: PURPOSE: A methanol extract of Persicaria hydropiper (L.) SPACH is provided to suppress NO generation and TNF-alpha and AP-1 expression. CONSTITUTION: A methanol extract of Persicaria hydropiper (L.) SPACH with anti-inflammatory and immunosuppressive effects contains quercetin 3-O-beta-L-rhamnoside, kaempferol-3-glucoside, 6-hydrolxyapigenin, galloyl kaepferol 3-glucoside, scutellarein, 6-hydroxylutelin, 6-hydroxyluteolin-7-O-beta-D-glucopyranoside, quercetin 3-O-beta-D-glucuronide, galloyl, quercetin, and quercetin flavonoid.
Abstract translation: 目的：提供Persicaria hydropiper（L.）SPACH的甲醇提取物以抑制NO产生和TNF-α和AP-1表达。 构成：具有抗炎和免疫抑制作用的Persicaria hydropiper（L.）SPACH的甲醇提取物含有槲皮素3-O-β-L-鼠李糖苷，山奈酚-3-葡萄糖苷，6-羟丙基青霉素，galloyl kaepferol 3-葡萄糖苷，scutellarein， 6-羟基脯氨酸-7-O-β-D-吡喃葡萄糖苷，槲皮素3-O-β-D-葡糖苷酸，酰基，槲皮素和槲皮素类黄酮。
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公开(公告)号：KR100953177B1
公开(公告)日：2010-04-15
申请号：KR1020090132891
申请日：2009-12-29
Applicant: 강원대학교산학협력단
IPC: A61K31/167 , A61K31/166 , A61P29/00 , A23L1/30
Abstract: PURPOSE: A resveratrol derivative compound having activities of anti-inflammation and immune modulation is provided to reduce NO generation and suppress anti-inflammation with low cytotoxicity. CONSTITUTION: A composition for preventing or treating inflammatory diseases contains a compound of chemical formula 1 as an active ingredient. In chemical formula 1, OH is substituted with ortho, meta or para of phenyl ring; either m or n is not 0 and independently 0, 1 or 2. A functional health food for preventing or treating inflammatory diseases contains resveratrol derivative of chemical formula 1 and sitologically acceptable food additive.
Abstract translation: 目的：提供具有抗炎和免疫调节活性的白藜芦醇衍生物，以减少NO产生，抑制细胞毒性低的抗炎。 构成：用于预防或治疗炎性疾病的组合物含有化学式1化合物作为活性成分。 在化学式1中，OH被苯环的邻位，间位或对位取代; m或n不为0且独立地为0,1或2.用于预防或治疗炎性疾病的功能性保健食品包含化学式1的白藜芦醇衍生物和可以使用的可食用食品添加剂。
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20.发明公开
公开(公告)号：KR1020090015766A
公开(公告)日：2009-02-12
申请号：KR1020070080366
申请日：2007-08-09
Applicant: 강원대학교산학협력단
IPC: A61K31/435 , A61P29/00 , A61P37/02 , A61P35/00
CPC classification number: Y02A50/409 , A61K31/435 , Y10S514/814 , Y10S514/824 , Y10S514/825 , Y10S514/866 , Y10S514/885 , Y10S514/886 , Y10S514/925
Abstract: A composition comprising 8-(tosylamino)quinoline is provided to inhibit production of nitric oxide, growth of cancer cells and C6 glioma cell, production of PGE2(prostaglandin 2), and activity of IKK(I kappa B alpha kinase) and Src kinase, thereby preventing or treating inflammatory diseases, immune diseases or tumors. The composition for preventing or treating inflammatory diseases, immune diseases or tumors comprises 8-(tosylamino)quinoline or pharmaceutically acceptable salts thereof including an acid addition salt selected from hydrochloric acid, hydrobromic acid, phosphonic acid, sulfuric acid, tartaric acid, acetic acid, citric acid, malic acid, methanesulphonic acid and gluconic acid.
Abstract translation: 提供了包含8-（甲苯磺酰氨基）喹啉的组合物以抑制一氧化氮的产生，癌细胞和C6胶质瘤细胞的生长，PGE2（前列腺素2）的产生以及IKK（IκBα激酶）和Src激酶的活性， 从而预防或治疗炎性疾病，免疫疾病或肿瘤。 用于预防或治疗炎性疾病，免疫疾病或肿瘤的组合物包含8-（甲苯磺酰氨基）喹啉或其药学上可接受的盐，包括选自盐酸，氢溴酸，膦酸，硫酸，酒石酸，乙酸， 柠檬酸，苹果酸，甲磺酸和葡萄糖酸。
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