公开(公告)号：KR1020100106791A

公开(公告)日：2010-10-04

申请号：KR1020090024979

申请日：2009-03-24

Applicant: 주식회사 알로페론 ,  세종대학교산학협력단

Inventor： 김수인 ,  이왕재 ,  임동렬

IPC: C07K7/06 ,  A61K38/08 ,  A61P31/12 ,  A61P35/00

Abstract: PURPOSE: An antiviral or anticancer drug containing peptide analogue with histidine is provided to control NF-kappaB activity and to prevent or treat NF-kappaB-associated diseases. CONSTITUTION: A peptide analogue with histidine is denoted by formula I(X1-His-X2-X3-His-Gly-X4). In formula I, X does not exist or is at least one amino acid or amino acid having alkyl or an aryl group; X2 is an amino acid having beta-amino acid, gamma-amino acid, D-form amino acid, or N-methyl amino acid; X3 does not exist or is an amino acid with gamma-amino acid, D-form amino acid or N-methyl amino acid; X3 does not exist or is an amino acid having L-form amino acid, D-form amino acid, or N-methyl amino acid; and X4 is an amino acid having L-form amino acid, D-form amino acid or N-methyl amino acid. The peptide analogue is Gly-His-β-Ala-Gln-His-Gly-Val. A composition for treating a NF-kappaB-associated disease contains NF-kappaB activity-regulating material having the peptide analogue and hydrate or salt thereof as an active ingredient.

Abstract translation: 目的：提供含有组氨酸的肽类似物的抗病毒或抗癌药物以控制NF-κB活性并预防或治疗NF-κB相关疾病。 构成：具有组氨酸的肽类似物由式I（X1-His-X2-X3-His-Gly-X4）表示。 在式I中，X不存在或至少一个具有烷基或芳基的氨基酸或氨基酸; X2是具有β-氨基酸，γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有γ-氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X3不存在或是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸; X4是具有L-型氨基酸，D-型氨基酸或N-甲基氨基酸的氨基酸。 肽类似物是Gly-His-β-Ala-Gln-His-Gly-Val。 用于治疗NF-κB相关疾病的组合物含有具有肽类似物和水合物或其盐作为活性成分的NF-κB活性调节材料。

公开(公告)号：KR101775440B1

公开(公告)日：2017-09-06

申请号：KR1020150141171

申请日：2015-10-07

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  최홍림 ,  메트레아몰 ,  허수향 ,  김선영 ,  남도현

IPC: C07D421/06 ,  C07D345/00 ,  C07D209/56 ,  A61K31/095 ,  A61K31/403 ,  A61K39/395 ,  A61K47/48

Abstract: 본원은신규벤조셀레노펜계화합물과이의제조방법및 벤조셀레노펜계화합물을포함하는항체-약물결합체(antibody-drug conjugate; ADC)에관한것이다.

公开(公告)号：KR1020140143345A

公开(公告)日：2014-12-16

申请号：KR1020140150420

申请日：2014-10-31

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  남도현 ,  두베이라스미

IPC: C07C391/02 ,  C07D317/46

Abstract: 본원은, 셀레닐-치환된 방향족 알데하이드(selenyl-substituted aromatic aldehyde)계 화합물의 신규한 제조 방법에 관한 것으로서, 구체적으로, 셀레놀레이트 친핵체(selenolate nucleophile)를 형성하여 방향족 알데하이드계 출발물질을 친핵성 치환시키는 것을 포함하는, 셀레닐-치환된 방향족 알데하이드계 화합물의 신규한 제조 방법에 관한 것이다.

Abstract translation: 本发明涉及一种制备烯酰基取代的芳族醛基化合物的新方法。 更具体地，该方法包括亲核取代基于芳族醛的原料的步骤。

公开(公告)号：KR1020140123470A

公开(公告)日：2014-10-22

申请号：KR1020140133014

申请日：2014-10-02

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  남도현 ,  두베이라스미 ,  이한근

IPC: C07D421/06 ,  C07D421/14 ,  A61K31/555 ,  A61P35/00

Abstract: 셀레노펜-접합 방향족(selenophene-fused aromatic) 화합물을 포함하는 항암제에 관한 것이다.

Abstract translation: 本发明涉及含硒硒稠合芳族化合物的抗癌剂。 本发明可以更容易且经济地制备具有各种取代基的硒酚稠合芳香族化合物，并且在制备硒代苯并稠合芳香族化合物时，作为原料的芳香族起始原料的种类多样化， 稠合芳香族化合物。

公开(公告)号：KR1020130064018A

公开(公告)日：2013-06-17

申请号：KR1020120139440

申请日：2012-12-04

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  남도현 ,  두베이라스미 ,  이한근

IPC: C07D421/06 ,  C07D421/14 ,  A61K31/555 ,  A61P35/00

Abstract: PURPOSE: An anticancer agent containing a selenophene-conjugated aromatic compound is provided to easily and cheaply obtain the selenophene-conjugated aromatic compound. CONSTITUTION: A selenophene-conjugated aromatic compound is denoted by chemical formula 1, 2, and 3. An anticancer composition contains the selenophene-conjugated aromatic compound. A method for preparing the selenophene-conjugated aromatic compound comprises a step of reacting an MCBI(7-methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one) compound of chemical formula 1a and a selenium-containing aromatic compound of chemical formula 1b.

Abstract translation: 目的：提供含有硒吩酚共轭芳香族化合物的抗癌剂，容易且廉价地得到硒吩衍生的芳香族化合物。 构成：硒酚共轭芳族化合物由化学式1,2和3表示。抗癌组合物含有硒吩酚共轭芳族化合物。 制备该硒代苯并咪唑化合物的方法包括使化学式1a的MCBI（7-甲氧基-1,2,9,9a-四氢环丙[c]苯并[e]吲哚-4-酮）化合物与 化学式1b的含硒芳香族化合物。

公开(公告)号：KR101050273B1

公开(公告)日：2011-07-19

申请号：KR1020080116406

申请日：2008-11-21

Applicant: 세종대학교산학협력단

Inventor： 임동렬 ,  박원철

IPC: C07F15/06 ,  C07F15/02 ,  C07F15/04

Abstract: 본 발명은 하기 의 살렌 전이금속 착화합물을 개시한다:


상기 식에서,
R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 , Ar
1 , Ar
2 , A , M, X, m 및 n은 발명의 상세한 설명을 참조한다.
살렌

Abstract translation: 本发明涉及到＆lt;公开的沙仑 - 过渡金属配合物;式1＆GT：

公开(公告)号：KR100724586B1

公开(公告)日：2007-06-04

申请号：KR1020050120371

申请日：2005-12-09

Applicant: 세종대학교산학협력단 ,  재단법인서울대학교산학협력재단

Inventor： 임동렬 ,  정진호 ,  박원철

IPC: C07F13/00 ,  C07D471/00 ,  C07F1/08

Abstract: A pentaaza macrocycle metal complex is provided to show excellent active oxygen scavenging capability with less toxicity and side effect, thereby being used as a pharmaceutical composition for preventing or treating diseases related to the active oxygen such as skin aging, cancer, dementia, and rheumatoid. The pentaaza macrocycle metal complex is represented by the formula(I), wherein each R1, R2, R3 and R4 is independently H or C1-4 alkyl substituted by a hetero cycle or an aromatic cycle, the hetero cycle and the aromatic cycle able to be substituted by at least one substituent selected from the group consisting of C1-4 alkoxy, halogen, nitro, cyano, hydroxy, carboxyl and amino, each R5 and R6 is independently C1-7 alkyl or the R5 and R6 form a ring by being bound by C3-5 alkylene, M is a divalent metal selected from the group consisting of Mn, Fe and Cu, and each X and Y is independently a halide anion selected from the group consisting of Cl, Br, I, ClO3, ClO2, ClO, BrO4, BrO3, BrO2, BrO, IO4, and IO3, an anion of an organocarboxylic acid selected from the group consisting of acetic acid, trifluoroacetic acid, citric acid, formic acid, maleic acid, oxalic acid, succinic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, ascorbic acid, malic acid, methane sulfonic acid, benzene sulfonic acid and para-toluene sulfonic acid, an anion of a nitrate or a bicarbonate, and carboxylate or phenolate linked to one of the R1 to R6, provided that at least one of the R1, R2, R3 and R4 is not H. The pharmaceutical composition for preventing and treating cancer, stroke, Parkinson's disease, Alzheimer's disease, myocardial infarction, diabetic vascular disorder, hyperlipidemia, acute inflammation, rheumatoid, alcoholic hepatitis, glaucoma, macular degeneration and diabetic retinopathy comprises the pentaaza macrocycle metal complex as an effective ingredient.

Abstract translation: 本发明提供五氮杂大环金属络合物，其显示优异的活性氧清除能力，毒性和副作用较小，因此可用作预防或治疗与皮肤老化，癌症，痴呆和类风湿等活性氧有关的疾病的药物组合物。 五氮杂大环金属配合物由式（I）表示，其中每个R 1，R 2，R 3和R 4独立地为H或被杂环或芳环取代的C 1-4烷基，杂环和芳环可以 被至少一个选自C 1-4烷氧基，卤素，硝基，氰基，羟基，羧基和氨基的取代基取代，每个R 5和R 6独立地为C 1-7烷基或者R 5和R 6通过 M是选自Mn，Fe和Cu的二价金属，并且每个X和Y独立地是选自Cl，Br，I，ClO 3，ClO 2， ClO，BrO 4，BrO 3，BrO 2，BrO，IO 4和IO 3，选自乙酸，三氟乙酸，柠檬酸，甲酸，马来酸，草酸，琥珀酸，苯甲酸的有机羧酸的阴离子 ，酒石酸，富马酸，扁桃酸，抗坏血酸，苹果酸，甲磺酸，b 苯磺酸和对甲苯磺酸，硝酸盐或碳酸氢盐的阴离子以及与R1-R6之一连接的羧酸盐或酚盐，条件是R1，R2，R3和R4中的至少一个不是H. 用于预防和治疗癌症，中风，帕金森病，阿尔茨海默氏病，心肌梗塞，糖尿病血管病症，高脂血症，急性炎症，类风湿，酒精性肝炎，青光眼，黄斑变性和糖尿病性视网膜病的药物组合物包含五氮杂大环金属络合物作为有效 成分。

公开(公告)号：KR1020170038770A

公开(公告)日：2017-04-07

申请号：KR1020170038519

申请日：2017-03-27

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  남도현 ,  두베이라스미

IPC: C07C391/02 ,  C07D317/46

Abstract: 본원은, 셀레닐-치환된방향족알데하이드(selenyl-substituted aromatic aldehyde)계화합물의신규한제조방법에관한것으로서, 구체적으로, 셀레놀레이트친핵체(selenolate nucleophile)를형성하여방향족알데하이드계출발물질을친핵성치환시키는것을포함하는, 셀레닐-치환된방향족알데하이드계화합물의신규한제조방법에관한것이다.

Abstract translation: 本发明涉及一种制备硒代 - 取代的芳香醛基化合物的新方法，更具体地涉及一种制备硒代亲核试剂以形成芳香醛 - 取代的芳香醛基化合物。

公开(公告)号：KR1020130069463A

公开(公告)日：2013-06-26

申请号：KR1020120145699

申请日：2012-12-13

Applicant: 세종대학교산학협력단 ,  서울대학교산학협력단

Inventor： 임동렬 ,  강헌중 ,  이동섭 ,  전보람 ,  신원섭

IPC: C07D493/22 ,  A61K31/335 ,  A61P35/00

Abstract: PURPOSE: A pectenotoxin-2 derivative with various useful physical properties is provided to be used as an anticancer agent or a precursor thereof. CONSTITUTION: A pectenotoxin-2 derivative is denoted by chemical formula 1. An anticancer composition contains the derivative and removes cancer cells in human body. The cancer cells include cancer cells of lung, colon, central nervous system, skin, ovary, kidney, breast, or stomach.

Abstract translation: 目的：提供具有各种有用物理性质的果胶毒素-2衍生物作为抗癌剂或其前体。 构成：化学式1表示果胶毒素-2衍生物。抗癌组合物含有衍生物并去除人体中的癌细胞。 癌细胞包括肺，结肠，中枢神经系统，皮肤，卵巢，肾，乳腺或胃的癌细胞。

公开(公告)号：KR1020120125573A

公开(公告)日：2012-11-15

申请号：KR1020110042766

申请日：2011-05-06

Applicant: 세종대학교산학협력단 ,  사회복지법인 삼성생명공익재단

Inventor： 임동렬 ,  남도현 ,  두베이라스미

IPC: C07C391/02 ,  C07D317/46 ,  C07D211/80 ,  C07D491/06

Abstract: PURPOSE: A manufacturing method of selenyl-substituted aromatic aldehyde-based compound is provided to obtain selenyl-sbustituted aromatic aldehyde-based compound with high yield while minimizing generation of byproduct of a reaction. CONSTITUTION: A manufacturing method of selenyl-substituted aromatic aldehyde-based compound indicated in chemical formula 4 comprises: a step of preparing a reaction mixture comprising diselenide compound represented by A-Se-Se-A, solvent and a reducing agent; and a step of adding and reacting aromatic aldehyde-based starting material and base into the reaction mixture. The equivalent ratio of the diselenide compound and the reducing agent in the reaction mixture is 1:1/3-3.

Abstract translation: 目的：提供烯丙基取代的芳族醛基化合物的制备方法，以最大限度地产生反应副产物的产率，以高产率获得烯丙基取代的芳族醛基化合物。 构成：化学式4中所示的苯乙烯基取代的芳族醛基化合物的制造方法包括：制备包含由A-Se-Se-A表示的二硒化合物，溶剂和还原剂的反应混合物的步骤; 和将芳族醛类原料和碱加入反应混合物中的步骤。 反应混合物中二硒化合物和还原剂的当量比为1:1 / 3-3。