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12.发明授权3-클로로-2-(4-클로로-2-플루오로-5-히드록시페닐)-4,5,6,7-테트라히드로-2Ｈ-인다졸의 제조방법 失效3-클로로-2-（4-클로로-2-플루오로-5-록드록시페닐）-4,5,6,7-테트라히드로-2H-인다졸의제조방3-
公开(公告)号：KR100454090B1
公开(公告)日：2004-10-26
申请号：KR1020020033207
申请日：2002-06-14
Applicant: 한국화학연구원
IPC: C07D231/54
Abstract: PURPOSE: A process for preparing 3-chloro-2- (4-chloro-2-fluoro-5-hydroxyphenyl)- 4,5,6,7-tetrahydro-2H-indazole is provided, thereby improving its preparation yield and converting by-products of the preparation into starting material. CONSTITUTION: A process for preparing 3-chloro-2- (4-chloro-2-fluoro-5-hydroxyphenyl)- 4,5,6,7-tetrahydro-2H-indazole of the formula 1 comprises the steps of: reacting 2- (2-fluoro-4-chloro-5-hydroxyphenyl)- 2,3a,4,5,6,7- hexahydroindazole-3-one of the formula 2 with phosgene; concentrating the phosgene reaction mixture under reduced pressure; dissolving the concentrate in an organic solvent; adding ammonia water or hydroxide solution to the organic solvent and filtering solids; and distilling the filtrated solution, wherein the organic solvent is ethylacetate; the addition of ammonia water or hydroxide solution is carried out at room temperature; the solids are mainly constituted of a compound of the formula 2, and the by-products of the reaction include a dimer represented by the formula 3a, 3b or 3c.
Abstract translation: 目的：提供一种制备3-氯-2-（4-氯-2-氟-5-羟基苯基）-4,5,6,7-四氢-2H-吲唑的方法，由此提高其制备产率和通过 - 将制剂的产物制成原料。 构成：制备式1的3-氯-2-（4-氯-2-氟-5-羟基苯基）-4,5,6,7-四氢-2H-吲唑的方法包括以下步骤：使2 - （2-氟-4-氯-5-羟基苯基）-2,3a，4,5,6,7-六氢吲唑-3-酮与光气的反应; 在减压下浓缩光气反应混合物; 将浓缩物溶解在有机溶剂中; 向有机溶剂中加入氨水或氢氧化物溶液并过滤固体; 蒸馏过滤后的溶液，其中有机溶剂为乙酸乙酯; 氨水或氢氧化钠溶液的加入在室温下进行; 固体主要由式2的化合物构成，并且反应的副产物包括由式3a，3b或3c表示的二聚体。
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公开(公告)号：KR100392072B1
公开(公告)日：2003-07-22
申请号：KR1020000052917
申请日：2000-09-07
Applicant: 한국화학연구원
IPC: A01N43/80
CPC classification number: A01N43/80
Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.
Abstract translation: 本发明提供了式（1）的新型5-苄氧基甲基-1,2-异恶唑啉衍生物及其制备方法和它们作为除草剂的用途。 即使在低剂量率下，本发明的5-苄氧基甲基-1,2-异恶唑啉衍生物对稻田杂草具有足够高的除草活性，特别是对转移的稻米具有优异的选择性。 因此，本发明的化合物通常可用作除草剂以控制稻中的稻田杂草。
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公开(公告)号：KR1020000059735A
公开(公告)日：2000-10-05
申请号：KR1019990007558
申请日：1999-03-08
Applicant: 한국화학연구원
IPC: C07D413/12
Abstract: PURPOSE: A N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is provided which has excellent stability against a rice plant and shows good herbicidal activity on weeds in a paddy like echor, scpju, moova, cypse, sagpy or so on. CONSTITUTION: The N-(5-isoxazolinylmethyloxyphenyl)-dimethylmaleimide derivative is shown in a chemical formula 1 wherein R is alkyl radical with 1-5 carbon number, phenyl radical or substituted phenyl radical, cyano radical, carboxylic acid or carboxylic ester, heterocyclic or substituted heterocyclic radical. The substituted phenyl radical or substituted heterocyclic radical is simply or mixedly substituted from 1-3 radicals among alkyl radical with 1-3 carbon number, alkoxy radial with 1-3 carbon number, halogen atom, cyano radical, nitro radical, carboxyl radical and carboxylic ester.
Abstract translation: 目的：提供一种对水稻植株具有优异稳定性的N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物，对水稻，scpju，moova，cypse，sagpy等中的杂草具有良好的除草活性。 组成：N-（5-异恶唑啉基甲氧基苯基） - 二甲基马来酰亚胺衍生物以化学式1表示，其中R是具有1-5个碳数的烷基，苯基或取代的苯基，氰基，羧酸或羧酸酯，杂环或 取代的杂环基。 取代的苯基或取代的杂环基团在具有1-3个碳原子的烷基，具有1-3个碳数的烷氧基，卤素原子，氰基，硝基，羧基和羧基的烷基中简单或混合取代1-3个基团 酯。
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公开(公告)号：KR100250838B1
公开(公告)日：2000-05-01
申请号：KR1019970065411
申请日：1997-12-02
Applicant: 한국화학연구원
IPC: C07D307/08
Abstract: PURPOSE: Provided is a preparation method of 3(-(hydroxymethyl)tetrahydrofuran) represented by the formula (1) which is used as an intermediate raw material of drugs and insecticide. Thereby the compound is simply and easily prepared compared to the conventional methods. CONSTITUTION: (3-(hydroxymethyl)tetrahydrofuran) of the formula (1) is prepared by cyclization reaction of 2-hydroxymethyl-4-alkene-1-ol derivative of the formula (2) in the presence of I2 catalyst in organic solvent, wherein R1, R2 and R3 are C1-C4 alkyl or phenyl selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl and t-butyl, respectively.
Abstract translation: 目的：提供用作药物和杀虫剂的中间体原料的由式（1）表示的3（ - （羟甲基）四氢呋喃）的制备方法。 因此，与常规方法相比，化合物简单且容易地制备。 组成：通式（2）的2-羟甲基-4-烯-1-醇衍生物在有机溶剂中存在的I2催化剂的环化反应制备式（1）的（3-（羟甲基）四氢呋喃） 其中R1，R2和R3分别是C1-C4烷基或选自氢，甲基，乙基，正丙基，异丙基，正丁基，异丁基和叔丁基的苯基。
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Patent Agency Ranking
公开(公告)号：KR100248945B1
公开(公告)日：2000-04-01
申请号：KR1019970065413
申请日：1997-12-02
Applicant: 한국화학연구원
IPC: A01N43/76
Abstract: 본 발명은 화학식 1로 표시되는 제초성 3-아릴-테트라히드로-1,2-벤즈이속사졸린-4-온 유도체에 관한 것이다.
상기식에서 Xn은 수소, C
1 -C
4 알킬기, C
2 -C
5 알케닐기, C
2 -C
5 알키닐기, C
1 -C
4 알콕시기, C
1 -C
4 할로알킬기, C
1 -C
4 알콕시카보닐기, 아미노카보닐기, 카복시기, 메탄설포닐기, 니트로기, 히드록시기, 니트릴기, 또는 이들의 둘이상의 복합치환기를 나타낸다.-
公开(公告)号：KR100128544B1
公开(公告)日：1998-04-04
申请号：KR1019940016984
申请日：1994-07-14
Applicant: 한국화학연구원
IPC: C07D209/32 , C07D209/42
Abstract: Title derivatives(I; R1, R2= same or not, H, fluro, chlorro, bromo, C1-3 alkyl, C1-3 alkoxy; R1 and R2 are formed a fused ring such as -CH=CH-CH=CH-; R3= H, C1-4 alkyl, C3-6 alkenyl, etc.), useful as herbicides were prepared. Thus, 3.03 g 4-fluorophenol was reacted with 1.9 ml ethyl chloride, followed by addition of 4.0 g anhydrous aluminium chloride at 180 deg.C for 30 minutes to give 2.71 g 2-hydroxy-5-fluoroacetophenone(III). III and 1.05 g ethyl carbamate were refluxed for 20- 30 hours in 50 ml n-propanol to give ethoxycarbonylhydrazone derivatives IV. 2.41 g IV was dissolved in 100 ml tetrahydrofuran, adding 4.44 g (CH3COO)4Pb as an oxidation agent at room temperature for 3- 5 hours to give ethyl 0-acetylarylcarboxylate derivatives(V). 2.1 g V and 0.83 g 4-chloro-2-fluoro-5-hydroxyaniline were refluxed for 20- 30 hours in a mixed solvent of 50 ml o-dichlorobenzene and acetic acid to give 2,3-dihydro-3-methylene- 2-(4-chloro-2-fluoro-3-hydroxyphenyl)-1H-isoindol-1-one(VII). VII was refluxed for 20 hours to give 2,3-dihydro-3-methylene-2- (3-propagyloxy-4-chloro-2-fluorophenyl)-1H-isoindol-1-one(I).
Abstract translation: 标题衍生物（I; R1，R2 =相同或不同，H，氟，氯，溴，C1-3烷基，C1-3烷氧基; R1和R2形成稠环，例如-CH = CH-CH = CH- ; R3 = H，C1-4烷基，C3-6烯基等），可用作除草剂。 因此，将3.03g 4-氟苯酚与1.9ml氯乙烷反应，然后在180℃下加入4.0g无水氯化铝30分钟，得到2.71g 2-羟基-5-氟苯乙酮（III）。 III和1.05g氨基甲酸乙酯在50ml正丙醇中回流20-30小时，得到乙氧基羰基腙衍生物IV。 将2.41g IV溶解在100ml四氢呋喃中，在室温下加入4.44g（CH3COO）4Pb作为氧化剂，持续3-5小时，得到O-乙酰基芳基羧酸乙酯衍生物（V）。 将2.1g V和0.83g 4-氯-2-氟-5-羟基苯胺在50ml邻二氯苯和乙酸的混合溶剂中回流20-30小时，得到2,3-二氢-3-亚甲基-2 - （4-氯-2-氟-3-羟基苯基）-1H-异吲哚-1-酮（VII）。 VII的混合物回流20小时，得到2,3-二氢-3-亚甲基-2-（3-羰基氧基-4-氯-2-氟苯基）-1H-异吲哚-1-酮（I）。
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公开(公告)号：KR1019960022496A
公开(公告)日：1996-07-18
申请号：KR1019940037131
申请日：1994-12-27
Applicant: 한국화학연구원
IPC: C07D307/79
Abstract: 본 발명은 농약 및 의약의 중간체로 유용한 다음 구조식(Ⅰ)로 표시되는 2,3-디히드로-2-메틸-2-알킬 벤조퓨란 유도체의 제조방법에 관한 것이다.
상기 식에서, X는 수소원자, 할로겐원자, 히드록시기, 알데히드기 또는 C
1 ∼C
6 의 알킬기이고, R은 C
1 ∼C
6 의 알킬이다.-
公开(公告)号：KR1019960007549A
公开(公告)日：1996-03-22
申请号：KR1019940020420
申请日：1994-08-18
Applicant: 한국화학연구원
IPC: C07C251/44 , A01N35/10 , C07C47/546 , C07C49/723 , C07C251/42
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