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公开(公告)号：KR1020090078939A
公开(公告)日：2009-07-21
申请号：KR1020080004805
申请日：2008-01-16
IPC: A61K31/192 , A61K31/045 , A61K31/343 , A61P25/28
Abstract: A composition for preventing and treating neutodegenerative disease, which contains a polyphenol compound as an active ingredient is provided to have the effects of beta-amyloid coagulation inhibition, caspase-3 activity suppression and acetylcholinesterase activation suppression. A composition for preventing and treating neurodegenerative diseases comprises salvianolic acid, bakuchiol, epsilon-viniferin, rhapontigenin, piceatannol, luteolin, myricetin, or their mixture as an active ingredient. The neurodegenerative diseases are Alzheimer's disease, Pick's disease, Creutzfeldt-jakob, Parkinson's disease, Lou Gehrig's Disease, or Huntington's disease. The composition suppresses BACE-1[beta-site APP(amyloid precursor protein)-cleaving enzyme 1], caspase or acetylcholine esterase. The composition further comprises medicinal herb. The medicinal herb is Salviae Miltiorrhizae Radix, Psoraleae Semen, Vitidis Fructus, Rhei Rhizoma, Digitalis Folium, Schizonepeta Herba, Taraxaci Herba, Humuli Herba, Lonicerae Folium or their mixture.
Abstract translation: 提供含有多酚化合物作为活性成分的用于预防和治疗神经变性疾病的组合物，以具有β-淀粉样蛋白凝结抑制，半胱天冬酶-3活性抑制和乙酰胆碱酯酶活化抑制的作用。 用于预防和治疗神经变性疾病的组合物包括salvianolic acid，bakuchiol，ε-viniferin，rhapontigenin，piceatannol，木犀草素，杨梅宁或其混合物作为活性成分。 神经变性疾病是阿尔茨海默氏病，皮克病，克雅氏综合征，帕金森氏病，卢格里希氏病或亨廷顿舞蹈病。 该组合物抑制BACE-1β-位点APP（淀粉样蛋白前体蛋白）切割酶1]，半胱天冬酶或乙酰胆碱酯酶。 该组合物还包含药草。 药用草药是丹参，枸杞子，枸杞子，枸杞子，洋地黄属，荆芥草，竹aci草，虎嘴草，金银花或其混合物。
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公开(公告)号：KR1020050115138A
公开(公告)日：2005-12-07
申请号：KR1020040040484
申请日：2004-06-03
Applicant: 한국화학연구원
IPC: A01N65/42
CPC classification number: A01N65/42 , A01N25/12 , A01N25/30 , C02F3/327 , C02F2103/007 , C02F2103/08
Abstract: 본 발명은 둥굴레속(
Polygonatum ) 식물 또는 그 추출물을 유효성분으로 함유하는 유해조류 및 개구리밥 방제 조성물 및 이를 이용한 방제방법에 관한 것으로, 본 발명의 둥굴레속 식물 또는 그 추출물은 유익한 조류나 수생생물에는 무해하면서, 남조류 및 적조류 등의 유해조류에만 선택적으로 우수한 방제효능을 나타내고, 다른 방제활성을 가진 화합물들과 상가적 효과를 나타내므로, 이를 함유하는 방제 조성물은 자연친화적이면서 효능이 우수한 유해조류 방제제로서 유용하게 활용될 수 있다.-
公开(公告)号：KR1020030021015A
公开(公告)日：2003-03-12
申请号：KR1020010054440
申请日：2001-09-05
Applicant: 한국화학연구원
IPC: A01N63/02
CPC classification number: A01N63/02
Abstract: PURPOSE: Provided are a novel Pythium myriotylum strain, a pathogen of plants, and a method for the biological control of weeds using same, thereby effectively and selectively removing weeds from a rice field. CONSTITUTION: The novel strain, Pythium myriotylum MD2(KCTC 10034BP) is used for selectively controlling weeds selected from American black cherry, Monochoria vaginalis, yellow birtch, Chondostereum purpureum, Northern joint vetch, Colletotrichum gloeosporioides f. sp. aeschynomene, Morrenia odorata, Phyrophthora palmivora, Poa annua, Pseudomonas gladioli, etc.
Abstract translation: 目的：提供一种新颖的植物真菌腐质菌菌株，以及使用该杂草的生物防治杂草的方法，从而有效地选择性地从稻田中除去杂草。 构成：新型菌株，真菌腐质霉MD2（KCTC 10034BP）用于选择性地控制选自美国黑樱桃，阴道阴道，黄色皮肤，紫色软骨，北方etch etch，，，ides ides ides controlling controlling controlling controlling controlling controlling controlling controlling controlling controlling。。。。。。。。。 SP。 aeschynomene，Morrenia odorata，Phyrophthora palmivora，Poa annua，Pseudomonas gladioli等
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14.发明公开신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물 有权新乙烯基[3,2-B]吡啶基脲衍生物或其药学上可接受的盐，其制备方法和药物组合物，用于预防或治疗UROTENSIN-II受体活性相关疾病包含作为活性成分的相关疾病
公开(公告)号：KR1020140102545A
公开(公告)日：2014-08-22
申请号：KR1020130016025
申请日：2013-02-14
Applicant: 한국화학연구원
IPC: C07D495/04 , A61K31/4365 , A61P9/00 , A61P25/00
Abstract: The present invention relates to a therapeutic use of novel thieno[3,2-b]pyridinyl urea derivatives and U-II receptor activity related diseases thereof. The thieno[3,2-b]pyridinyl urea derivatives, according to the present invention, acts as an antagonist for the U-II receptor, thus can be used for preventing or treating the U-II receptor activity diseases such as congestive heart failure, cardiac ischemia, myocardial infarction, cardiac hypertrophy and fibrosis, coronary heart disease, arteriosclerosis, hypertension, renal failure, diabetes, vascular inflammation, neurodegenerative diseases, stroke, pain, depression, psychosis, and cancer.
Abstract translation: 本发明涉及新型噻吩并[3,2-b]吡啶基脲衍生物及其与U-II受体活性有关的疾病的治疗用途。 根据本发明的噻吩并[3,2-b]吡啶基脲衍生物作为U-II受体的拮抗剂，因此可用于预防或治疗U-II受体活性疾病如充血性心力衰竭 心脏缺血，心肌梗塞，心脏肥大和纤维化，冠心病，动脉硬化，高血压，肾衰竭，糖尿病，血管炎症，神经变性疾病，中风，疼痛，抑郁，精神病和癌症。
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公开(公告)号：KR101077913B1
公开(公告)日：2011-10-31
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: 본발명은토양메타게놈유래신규에스터라제(esterase) 유전자및 이로부터암호화되는에스터라제단백질에관한것으로, 보다상세하게는토양미생물의총 유전체인메타게놈으로부터분리한신규에스터라제가우수한에스터라제활성을나타내고, 온도, pH 및유기용매에대한효소활성안정성을나타내며, 짧은사슬(short chain) 지방산을가지는지질및 3-하이드록시팔미트산메틸에스테르(3-OH palmitic acid methyl ester; 3-OH PAME)를분해하여식물병원성균에대한바이오필름저해활성을나타냄으로써식물세균병저항성작물또는식물세균병제어제개발에유용하게사용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020100091749A
公开(公告)日：2010-08-19
申请号：KR1020090011087
申请日：2009-02-11
Applicant: 한국화학연구원 , 동아대학교 산학협력단
IPC: C12N9/16 , C07K14/195 , C12N15/09 , A01H1/00
Abstract: PURPOSE: A soil metagenome-derived novel esterase gene is provided to ensure enzyme activity stability and to use in developing an agent which controls plant bacterial diseases. CONSTITUTION: A polypeptide having esterase activity comprises: a polypeptide encoded by polynucleotide of sequence number 1; a polypeptide encoded by a polynucleotide which is hybridized with the polynucleotide of sequence number 1; and a polypeptide with an amino acid sequence of sequence number 2. A method for preparing a recombinant esterase comprises: a step of preparing a recombinant expression vector containing the polynueotide; a step of preparing a transformant by introducing a recombinant expression vector to host cells; and a step of culturing the transformant to induce recombinant protein expression.
Abstract translation: 目的：提供一种土壤巨蛋白衍生新型酯酶基因，以确保酶活性的稳定性，并用于开发控制植物细菌性疾病的药剂。 构成：具有酯酶活性的多肽包括：由序列号1的多核苷酸编码的多肽; 由与序列号1的多核苷酸杂交的多核苷酸编码的多肽; 和具有序列号2的氨基酸序列的多肽。制备重组酯酶的方法包括：制备含有多核苷酸的重组表达载体的步骤; 通过将重组表达载体引入宿主细胞来制备转化体的步骤; 以及培养转化体诱导重组蛋白表达的步骤。
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17.发明公开상엽 추출물, 이의 분획물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 식욕 억제, 우울증의 예방 및 개선, 또는 불안증의 예방 및 개선용 식품 조성물 失效含有作为活性成分的以MCH受体拮抗活性为基础的MORI FOLIUM，其分离物或其化合物或其化合物用于预防或改善代谢或饮食障碍的饮食组合物
公开(公告)号：KR1020100024793A
公开(公告)日：2010-03-08
申请号：KR1020080083509
申请日：2008-08-26
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2200/332 , A23V2250/21
Abstract: PURPOSE: A food composition for preventing and improving of a metabolic disorder and an eating disorder based on MCH receptor antagonistic activity is provided to improve and prevent coronary artery diseases, hyperlipidemia, degenerative arthritis, melancholia, anxiety, and mental anxiety etc. CONSTITUTION: A food composition contains mulberry leaf extract extracted with a solvent including water, an organic solvent, or a mixture of water and the organic solvent as a beneficial component. The organic solvent is alcohol of C1-C4, dichloromethane or ethyl acetate. The alcohol of C1-C4 is methanol or ethanol. The mulberry leaf materials is produced by separating the mulberry leaf extract with dichloromethane.
Abstract translation: 目的：提供一种用于预防和改善基于MCH受体拮抗活性的代谢紊乱和进食障碍的食物组合物，用于改善和预防冠状动脉疾病，高脂血症，退行性关节炎，忧郁症，焦虑和精神焦虑等。构成：A 食品组合物含有用溶剂，包括水，有机溶剂或水和有机溶剂的混合物萃取的桑叶提取物作为有益成分。 有机溶剂是C1-C4的醇，二氯甲烷或乙酸乙酯。 C1-C4的醇是甲醇或乙醇。 通过将桑叶提取物与二氯甲烷分离来生产桑叶。
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18.发明公开[10]-진저다이온 또는 1-데하이드로-[10]-진저다이온을 포함하는 항 염증용 조성물 有权用于抗炎，组织改善的组合物，来自手术或布鲁斯的加速恢复，或治疗或预防心脏疾病，包括分离的ZINGIBER OFFICINALE或活性化合物的提取物
公开(公告)号：KR1020090104373A
公开(公告)日：2009-10-06
申请号：KR1020080029772
申请日：2008-03-31
Applicant: 한국화학연구원
IPC: A61K31/12 , A61K36/9068
CPC classification number: A61K31/12 , A23L2/52 , A23L29/035 , A61K36/9068 , Y10S514/886
Abstract: PURPOSE: A composition for treating or preventing heart diseases or for anti-inflammation, topical edema reduction, treatment or prevention of heart diseases is provided to enhance uptake function of macrophage and remove waste from the body. CONSTITUTION: A pharmaceutical composition for preventing or treating heart diseases or for anti-inflammation, topical edema reduction, or recovery promotion from surgery or contusion contains [10]-gingerdione of the chemical formula 1, 1-dehydro-[10]-gingerdione of the chemical formula 2 or their composite.
Abstract translation: 目的：提供用于治疗或预防心脏病或抗炎，局部水肿减轻，治疗或预防心脏病的组合物，以增强巨噬细胞的摄取功能，并从体内清除废物。 构成：用于预防或治疗心脏病或用于抗炎，局部水肿减轻或从手术或挫伤中恢复促进的药物组合物含有化学式1，1-dehydro- [10] - 二烯酮的[10] 化学式2或其复合物。
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公开(公告)号：KR100891762B1
公开(公告)日：2009-04-07
申请号：KR1020070000902
申请日：2007-01-04
CPC classification number: A61K36/78 , A23L2/38 , A23L33/105 , A23V2002/00 , A61K31/065 , A61K31/36 , A23V2200/326 , A23V2250/21
Abstract: 본 발명은 마칠린 디 (machilin D), 사우스네올 디 (saucerneol D) 및 이들의 혼합물로 구성된 군으로부터 선택된 화합물 또는 이를 포함하는 삼백초 (
Saururus chinenesis ) 뿌리 추출물을 유효성분으로 함유하는 혈관 이완용 조성물에 관한 것으로서, 본 발명에 따른 조성물은 혈관 평활근 이완작용을 통해 우수한 혈압 강하효과를 나타내므로, 고혈압 및 고혈압의 합병증으로 인한 각종 심혈관계 질환의 예방 및 치료를 위한 약학 조성물 또는 건강 식품 조성물로 유용하게 사용될 수 있다.-
公开(公告)号：KR100457069B1
公开(公告)日：2004-11-10
申请号：KR1020010054440
申请日：2001-09-05
Applicant: 한국화학연구원
IPC: A01N63/02
Abstract: PURPOSE: Provided are a novel Pythium myriotylum strain, a pathogen of plants, and a method for the biological control of weeds using same, thereby effectively and selectively removing weeds from a rice field. CONSTITUTION: The novel strain, Pythium myriotylum MD2(KCTC 10034BP) is used for selectively controlling weeds selected from American black cherry, Monochoria vaginalis, yellow birtch, Chondostereum purpureum, Northern joint vetch, Colletotrichum gloeosporioides f. sp. aeschynomene, Morrenia odorata, Phyrophthora palmivora, Poa annua, Pseudomonas gladioli, etc.
Abstract translation: 用途：提供了一种新型的Pythium myriotylum菌株，植物病原体，以及使用它的生物防治杂草的方法，由此有效地选择性地从稻田中除去杂草。 组成：新菌株Pythium myriotylum MD2（KCTC 10034BP）用于选择性控制选自美国黑樱桃，Monochoria vaginalis，黄色birtch，Chondostereum purpureum，Northern joint vetch，Colletotrichum gloeosporioides f。 SP。 aeschynomene，Morrenia odorata，Phyrophthora palmivora，Poa annua，唐菖蒲假单胞菌等
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