公开(公告)号：WO2012088094A3

公开(公告)日：2012-10-04

申请号：PCT/US2011066126

申请日：2011-12-20

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING

Inventor： HSIEH CHUNG-MING

IPC: A61K47/48 ,  C07K16/24

CPC classification number: A61K51/1021 ,  C07K16/245 ,  C07K2317/24 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention describes IL-1a binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1a. Binding proteins of the invention have high affinity for IL-1a and neutralize IL-1a activity. A binding protein of the invention can be a full-length antibody or an IL-1a -binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1a binding proteins of the invention are useful for detecting IL-1a and for inhibiting IL-1a activity, including in a human subject suffering from a disease or disorder in which IL-1a activity is detrimental.

Abstract translation: 本发明描述了IL-1a结合蛋白，包括结合IL-1a的嵌合，CDR移植和人源化抗体。 本发明的结合蛋白对IL-1a具有高亲和力并中和IL-1a活性。 本发明的结合蛋白可以是全长抗体或其IL-1a结合部分。 还描述了制备方法和使用本发明的结合蛋白的方法。 本发明的IL-1a结合蛋白可用于检测IL-1a和抑制IL-1a活性，包括在患有IL-1a活性有害的疾病或病症的人类受试者中。

公开(公告)号：WO2011143562A3

公开(公告)日：2012-03-01

申请号：PCT/US2011036444

申请日：2011-05-13

Applicant: ABBOTT LAB ,  WU CHENGBIN ,  AMBROSI DOMINIC J ,  HSIEH CHUNG-MING ,  GHAYUR TARIQ

Inventor： WU CHENGBIN ,  AMBROSI DOMINIC J ,  HSIEH CHUNG-MING ,  GHAYUR TARIQ

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C12P21/08

CPC classification number: C07K16/245 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/007 ,  A61K9/0085 ,  A61K38/00 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6879 ,  C07K14/545 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869 ,  G01N2333/545 ,  G01N2800/00

Abstract: Proteins that bind IL-1a and IL-1ß are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1 -related disorders and for detecting IL-1a and IL-1ß in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-1α和IL-1β的蛋白质及其在用于治疗，预防和诊断IL-1相关疾病的组合物和方法中的用途，并用于检测细胞，组织，样品中的IL-1α和IL-1β， 和组合物。

公开(公告)号：WO2011112566A3

公开(公告)日：2011-10-27

申请号：PCT/US2011027521

申请日：2011-03-08

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  BARLOW EVE H ,  KINGSBURY GILLIAN ANN ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN ,  KARAOGLU HANZATIAN DENISE D ,  BUCHANAN FRITZ G ,  LI YINGCHUN

Inventor： HSIEH CHUNG-MING ,  BARLOW EVE H ,  KINGSBURY GILLIAN ANN ,  REILLY EDWARD B ,  MORGAN-LAPPE SUSAN ,  KARAOGLU HANZATIAN DENISE D ,  BUCHANAN FRITZ G ,  LI YINGCHUN

IPC: C07K16/28 ,  C12P21/08

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

Abstract: Isolated binding proteins, e.g., antibodies, which bind to Basigin (BSG), e.g., human BSG2, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

Abstract translation: 公开了结合Basigin（BSG）（例如人BSG2）的分离的结合蛋白，例如抗体，以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用该抗体的治疗和诊断方法。

公开(公告)号：WO2010087972A3

公开(公告)日：2010-09-16

申请号：PCT/US2010000244

申请日：2010-01-29

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  WU CHENGBIN

Inventor： HSIEH CHUNG-MING ,  WU CHENGBIN

IPC: C07K16/24

CPC classification number: A61K39/3955 ,  A61K38/00 ,  A61K45/06 ,  A61K47/6845 ,  C07K16/245 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention encompasses IL-1a binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1a and neutralize IL-1a activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1a and for inhibiting IL-1a activity, e.g., in a human subject suffering from a disorder in which IL-1a activity is detrimental.

Abstract translation: 本发明包括IL-1a结合蛋白。 具体地，本发明涉及嵌合，CDR移植和人源化抗体的抗体。 本发明的抗体对IL-1a具有高亲和力并中和IL-1a活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测IL-1a和抑制IL-1a活性，例如在患有IL-1a活性有害的病症的人类受试者中。

公开(公告)号：WO2008082651A2

公开(公告)日：2008-07-10

申请号：PCT/US2007026482

申请日：2007-12-28

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92

Abstract: The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-l a and human IL-I ß. The dual specific antibodies of the invention also neutralize both human IL-I a and human IC-I ß. The invention also provides domain antibodies (dAbs) specific for human IL-l a and human IL-l ß.

Abstract translation: 本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。 本发明的双重特异性抗体还中和人IL-1α和人IC-1β。 本发明还提供对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

公开(公告)号：EP2403531A4

公开(公告)日：2013-02-27

申请号：EP10749415

申请日：2010-03-05

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins capable of binding human IL-17 and TNF-± are described along with their use in composition and methods for treating, preventing, and diagnosing diseases related to IL- 17 and TNF-± related diseases and for detecting and/or TNF-± in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白质及其在治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：EP2257638A4

公开(公告)日：2011-06-29

申请号：EP09719237

申请日：2009-03-03

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  BELK JONATHAN P ,  PEREZ JENNIFER M ,  BENATUIL LORENZO

IPC: C12Q1/68 ,  C40B40/02 ,  C40B50/06

CPC classification number: C12N15/87 ,  C12N1/16 ,  C12N1/18 ,  C12N13/00

公开(公告)号：EP2240581A4

公开(公告)日：2011-06-22

申请号：EP09703045

申请日：2009-01-15

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING

IPC: C12N15/00

CPC classification number: C12P21/00 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/52

公开(公告)号：EP2342562A4

公开(公告)日：2012-03-21

申请号：EP09818450

申请日：2009-09-30

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  KUTSKOVA YULIYA A ,  MEMMOTT JOHN E

IPC: G01N33/53 ,  C12N15/10

CPC classification number: G01N33/54326 ,  C12N15/1041

公开(公告)号：EP2114443A4

公开(公告)日：2011-08-10

申请号：EP07868125

申请日：2007-12-28

Applicant: ABBOTT LAB

Inventor： HSIEH CHUNG-MING ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  ROGUSKA MICHAEL ,  TOMLINSON IAN ,  TUNA MIHRIBAN ,  GRANT STEVEN ,  ENEVER CARRIE

IPC: A61K39/00

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/245 ,  C07K2317/569 ,  C07K2317/92