公开(公告)号：AU621317B2

公开(公告)日：1992-03-12

申请号：AU2567888

申请日：1988-11-17

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  C07K13/00 ,  G01N33/571 ,  C07K7/10 ,  C07K15/12 ,  G01N33/545 ,  G01N33/577 ,  C12N15/00 ,  A61K37/02 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.

公开(公告)号：AU593285B2

公开(公告)日：1990-02-08

申请号：AU6350286

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN WILLIAM E III ,  CLEMENS JOHN M ,  DEVEREAUX SHARON M ,  HOFLER JOHN G ,  KNIGGE KEVIN M ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76 ,  G01N33/545

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：DE3854550T2

公开(公告)日：1996-04-25

申请号：DE3854550

申请日：1988-11-03

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  A61K38/00 ,  G01N33/68 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.

公开(公告)号：DE3854550D1

公开(公告)日：1995-11-09

申请号：DE3854550

申请日：1988-11-03

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  A61K38/00 ,  G01N33/68 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.

公开(公告)号：AT128716T

公开(公告)日：1995-10-15

申请号：AT88118299

申请日：1988-11-03

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  A61K38/00 ,  G01N33/68 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.

公开(公告)号：AT78597T

公开(公告)日：1992-08-15

申请号：AT86113657

申请日：1986-10-03

Applicant: ABBOTT LAB

Inventor： BROWN III WILLIAM E ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  CLEMENS JOHN M ,  HOFLER JOHN G ,  SAFFORD SARAH E

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：AU7816591A

公开(公告)日：1991-10-10

申请号：AU7816591

申请日：1991-06-04

Applicant: ABBOTT LAB

Inventor： CHAN EMERSON W ,  SCHULZE WERNER ,  ROBEY WILLIAM GERARD ,  STOJAK JOSEPH J II ,  VALLARI DAVID S ,  BRAUN BRIAN P ,  DALUGA CYNTHIA K ,  KAPSALIS ANDREAS A ,  KNIGGE KEVIN M ,  STEPHENS JOHN E

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/571

Abstract: An immunoassay which is capable of simultaneously detecting any desired number of antigens of one infectious agent, or combinations of antigens of several infectious agents, or any desired number of immunoglobulins of one infectious agent, or combinations of immunoglobulins of several infectious agents on a single solid support. A test sample is contacted with a solid support on which one or more antigens are immobilized as discrete test sites. Antigen-antibody complexes are formed and detected on the solid support.

公开(公告)号：GR862328B

公开(公告)日：1987-01-19

申请号：GR860102328

申请日：1986-09-11

Applicant: ABBOTT LAB

Inventor： WILLIAM BROWN E ,  JOHN CLEMENS M ,  DEVEREAUX SHARON M ,  KNIGGE KEVIN M ,  SAFFORD SARAH E ,  HOFLER JOHN G

IPC: G01N33/548 ,  G01N31/22 ,  G01N33/52 ,  G01N33/543 ,  G01N33/546 ,  G01N33/569 ,  G01N33/576 ,  G01N33/76

Abstract: A novel material and device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample, particularly antigens or antibodies, is disclosed. The material comprises a porous matrix of fibers and a plurality of substantially spherical, solid particles having an average diameter of from about 0.1 to about 5 microns. The particles are retained and immobilized upon the fibers of the matrix. Preferably, the particles have on their surfaces a substance capable of reaction with the analyte in the sample, and the average diameter of the particles is less than the average pore size of the matrix. The device, in a preferred embodiment, comprises a substantially planar layer of the described material.

公开(公告)号：CA1340157C

公开(公告)日：1998-12-01

申请号：CA583731

申请日：1988-11-22

Applicant: ABBOTT LAB

Inventor： SARIN VIRENDER K ,  KNIGGE KEVIN M

IPC: C07K14/705 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/10 ,  C07K19/00 ,  C12N7/04 ,  C12N15/02 ,  C12P21/02 ,  C12P21/08 ,  G01N33/569 ,  A61K39/21

Abstract: Novel synthetic peptides which substantially replicate various sequences of gp160 envelope protein of the human immunodeficiency virus (HIV) are disclosed. Also disclosed are methods for detection of antibodies to HIV in biological samples using the gp160 peptides.

公开(公告)号：DE69029873D1

公开(公告)日：1997-03-20

申请号：DE69029873

申请日：1990-05-02

Applicant: ABBOTT LAB

Inventor： POPE MARK R ,  KNIGGE KEVIN M

IPC: G01N33/547 ,  G01N33/543 ,  G01N33/569

Abstract: The present invention provides novel methods for the covalent attachment of a specific binding member to a solid phase through the reaction of a thiolated solid phase and a specific binding member that is complexed to a heterobifunctional coupling agent. The resulting immobilized specific binding member can be used in diagnostic binding assays. The invention enables the production of immobilized specific binding members which have increased sensitivity, specificity and stability, while requiring less specific binding member be used.