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    2-halo-6-O-substituted erythromycin derivatives, a process for their preparation and pharmaceuticals thereof, useful for treating bacterial infections
    13.
    发明专利
    2-halo-6-O-substituted erythromycin derivatives, a process for their preparation and pharmaceuticals thereof, useful for treating bacterial infections 未知

    公开(公告)号：NZ503822A

    公开(公告)日：2002-12-20

    申请号：NZ50382298

    申请日：1998-10-29

    Applicant: ABBOTT LAB

    Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

    IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7052

    Abstract: A compound selected from the group consisting of (I) and (II), and pharmaceutically acceptable salts and esters thereof, wherein: RP is hydrogen or a hydroxy protecting group; X is F, Cl, Br, or I; and R1 is selected from the group consisting of: (1) Cl-C6-alkyl optionally substituted with one or more substituents selected from the group consisting of a) Aryl, b) Substituted aryl, c) Heteroaryl, d) Substituted heteroaryl, e) -NR3R4 wherein R3 and R4 are independently selected from hydrogen and Cl-C3-alkyl, or R3 and R4 are taken together with the atom to which they are attached form a 3-7 membered ring containing a moiety selected from the group consisting of-O-, -NH-, -N (CI-C6-alkyl-)-, -N (aryl-Cl-C6-alkyl-)-, -N (substituted aryl-Cl-C6-alkyl-)-, -N (heteroaryl-Cl-C6-alkyl-)-, and-N (substituted heteroaryl Cl-C6-alkyl-)- ; (2) -CH2-CH=CH-Y, wherein Y is selected from the group consisting of a) H; b) Aryl; c) Substituted aryl; d) Heteroaryl; e) Substituted heteroaryl; f) -CH=CH2; g) -CH=CH-aryl; h) -CH=CH-substituted aryl; i) -CH=CH-heteroaryl; and j) -CH=CH-substituted heteroaryl; k) (aryl) oyl; l) (substituted aryl) oyl; m) (heteroaryl) oyl; and n) (substituted heteroaryl) oyl; and (3) -CH2-C-=C-Y, wherein Y is as defined previously, with the proviso that in compounds of formula (II) wherein R1 is selected from option (1) the C1-C6-alkyl group must be substituted.

    DERIVADOS CETOLIDOS 6-O-ALQUIL-2-NOR-2-SUSTITUIDOS.
    19.
    发明专利
    DERIVADOS CETOLIDOS 6-O-ALQUIL-2-NOR-2-SUSTITUIDOS. 未知

    公开(公告)号：ES2306674T3

    公开(公告)日：2008-11-16

    申请号：ES00982357

    申请日：2000-12-01

    Applicant: ABBOTT LAB

    Inventor： PHAN LY TAM ,  OR YAT SUN ,  MA ZHENKUN

    IPC: C07H17/00 ,  A61K31/7052 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

    Abstract: Un compuesto de fórmula (Ver fórmula) o una sal farmacéuticamente admisible del mismo, en donde: R P es hidrógeno o un grupo protector de hidroxi, en donde el grupo protector de hidroxi es benzoílo; R 2 se selecciona del grupo que se compone de: (a) hidrógeno, y (b) heteroarilo, en donde el heteroarilo es quinolilo o quinoxalinilo; R 3 se selecciona del grupo que se compone de: (a) hidrógeno, (b) -OH, (c) F, Cl, Br o I, (d) alquilo C1 sustituido con un sustituyente -OH, (d) alquenilo C2-C6-R 2 , y (e) alquinilo C2-C6-R 2 ; R 4 se selecciona del grupo que se compone de: (a) hidrógeno, (b) OH, y (c) F, Cl, Br o I; o R 3 y R 4 tomados juntos forman =CH2 o -CH2O-; e Y es hidrógeno.

    20.
    发明专利
    未知

    公开(公告)号：DK1181299T3

    公开(公告)日：2008-10-27

    申请号：DK00930370

    申请日：2000-05-04

    Applicant: ABBOTT LAB

    Inventor： MA ZHENKUN ,  PHAN LY TAM ,  CLARK RICHARD F ,  ZHANG SUOMING ,  OR YAT SUN

    IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

    Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

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