公开(公告)号：WO02057286A3

公开(公告)日：2003-11-06

申请号：PCT/US0149634

申请日：2001-12-27

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Compounds of formula (I), and formula (II), or therapeutically acceptable salts or prodrugs thereof are useful as antibacterial agents. Methods to make the compounds, compositions containing the compounds, and methods of treatment using the compounds are also disclosed.

Abstract translation: 式（I）和式（II）的化合物或其治疗上可接受的盐或前药可用作抗菌剂。 还公开了使化合物，含有该化合物的组合物和使用该化合物的处理方法的方法。

公开(公告)号：PT1181299E

公开(公告)日：2008-09-18

申请号：PT00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  CLARK RICHARD F ,  OR YAT SUN ,  ZHANG SUOMING ,  PHAN LY TAM

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

公开(公告)号：AT398627T

公开(公告)日：2008-07-15

申请号：AT00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT ,  PHAN LY ,  ZHANG SUOMING ,  CLARK RICHARD

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

公开(公告)号：PE20020522A1

公开(公告)日：2002-06-25

申请号：PE2001001021

申请日：2001-10-15

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

Abstract: SE REFIERE A DERIVADOS DE ERITROMICINA (CETOLIDOS 6-O-SUSTITUIDOS) DE FORMULA I DONDE A1 ES ARILO, HETEROARILO; Y1 ES ISOXAZOL, OXAZOL, ISOTIAZOL, DIHIDROISOXAZOL, DIHIDROOXAZOL; D1 ES HC-CH; C C; R1 ES H, Rp; Rp ES UN GRUPO PROTECTOR DE OH. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS SIN PRODUCIR EL EFECTO COLATERAL DE INTOLERANCIA INTESTINAL COMO NAUSEAS, VOMITOS

公开(公告)号：ES2307511T3

公开(公告)日：2008-12-01

申请号：ES00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT SUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compuesto seleccionado del grupo que consiste en un compuesto de fórmula (I) (Ver fórmula) un compuesto de fórmula (II) (Ver fórmula) y un compuesto de fórmula (III) (Ver fórmula) y sus sales, ésteres, y profármacos farmacéuticamente aceptables, donde, en las fórmulas (I)-(III), Y y Z se seleccionan juntos del grupo que consiste en (1) oxo, (2) =N-OH, (3) =N-OR 1 donde R 1 se selecciona del grupo que consiste en (a) -alquilo C1-C12, (b) -alquilo C1-C12 sustituido con arilo, (c) -alquilo C1-C12 sustituido con arilo sustituido, (d) -alquilo C1-C12 sustituido con heteroarilo...

公开(公告)号：DE60039238D1

公开(公告)日：2008-07-31

申请号：DE60039238

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT SUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

公开(公告)号：PE05222002A1

公开(公告)日：2002-06-25

申请号：PE0010212001

申请日：2001-10-15

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: SE REFIERE A DERIVADOS DE ERITROMICINA (CETOLIDOS 6-O-SUSTITUIDOS) DE FORMULA I DONDE A1 ES ARILO, HETEROARILO; Y1 ES ISOXAZOL, OXAZOL, ISOTIAZOL, DIHIDROISOXAZOL, DIHIDROOXAZOL; D1 ES HC-CH; C C; R1 ES H, Rp; Rp ES UN GRUPO PROTECTOR DE OH. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS SIN PRODUCIR EL EFECTO COLATERAL DE INTOLERANCIA INTESTINAL COMO NAUSEAS, VOMITOS

公开(公告)号：DK1181299T3

公开(公告)日：2008-10-27

申请号：DK00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  CLARK RICHARD F ,  ZHANG SUOMING ,  OR YAT SUN

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.