公开(公告)号：WO02057286A3

公开(公告)日：2003-11-06

申请号：PCT/US0149634

申请日：2001-12-27

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: Compounds of formula (I), and formula (II), or therapeutically acceptable salts or prodrugs thereof are useful as antibacterial agents. Methods to make the compounds, compositions containing the compounds, and methods of treatment using the compounds are also disclosed.

Abstract translation: 式（I）和式（II）的化合物或其治疗上可接受的盐或前药可用作抗菌剂。 还公开了使化合物，含有该化合物的组合物和使用该化合物的处理方法的方法。

公开(公告)号：WO0232919A2

公开(公告)日：2002-04-25

申请号：PCT/US0132278

申请日：2001-10-16

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAM LY TAM ,  CLARK RICHARD F ,  ZHANG SOUMING ,  DJURIC STEVAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

CPC classification number: C07H17/08

Abstract: Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.

Abstract translation: 具有式（I）的化合物可用于治疗细菌感染，同时避免胃肠道不耐受的伴随的责任。 还公开了含有化合物的组合物和使用该化合物的处理方法。

公开(公告)号：WO03090679A2

公开(公告)日：2003-11-06

申请号：PCT/US0312590

申请日：2003-04-24

Applicant: ABBOTT LAB

Inventor： CLARK RICHARD ,  DJURIC STEVAN ,  MA ZHENKUN ,  WANG SANYI

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/08 ,  A61K

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 具有式（I）和式（II）的抗菌化合物及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及预防或治疗细菌感染的方法 公开了使用该化合物。

公开(公告)号：ES2378779T3

公开(公告)日：2012-04-17

申请号：ES06759877

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： GRACIAS VIJAYA ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN ,  JI ZHIQIN ,  MICHAELIDES MICHAEL ,  STEWART KENT ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551

Abstract: Un compuesto seleccionado del grupo que consiste en: N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-fenilurea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-fenilurea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[3-(trifluorometil)fenil]urea; N-[3-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(4-fluoro-3-metilfenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(2-fluoro-5-metilfenil)urea; N-[5-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)-2a metilfenil]-N'-[3-(trifluorometil)fenil]urea; N-[5-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)-2-metilfenil]-N'-(2-fluoro-5-metilfenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[2-fluoro-5-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-cloro-3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(3-clorofenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-fluoro-3-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-(3-bromofenil)urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[4-(trifluorometil)fenil]urea; N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-N'-[2-fluoro-3-(trifluorometil)fenil]urea; y N-[4-(4-amino-8,9-dihidro-7H-pirimido[4,5-b][1,4]diazepin-6-il)fenil]-3-[3-(trifluorometil)fenil]acrilamida.

公开(公告)号：CA2483221A1

公开(公告)日：2003-11-06

申请号：CA2483221

申请日：2003-04-23

Applicant: ABBOTT LAB

Inventor： SEARLE XENIA BEEBE ,  DJURIC STEVAN ,  YANG FAN ,  MA ZHENKUN

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds having formula (I), and salts, prodrugs, and salts o f prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：AT540951T

公开(公告)日：2012-01-15

申请号：AT06759877

申请日：2006-05-16

Applicant: ABBOTT LAB

Inventor： GRACIAS VIJAYA ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN ,  JI ZHIQIN ,  MICHAELIDES MICHAEL ,  STEWART KENT ,  ZANZE IRINI

IPC: C07D487/04 ,  A61K31/551

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2483281A1

公开(公告)日：2003-11-06

申请号：CA2483281

申请日：2003-04-24

Applicant: ABBOTT LAB

Inventor： WANG SANYI ,  MA ZHENKUN ,  DJURIC STEVAN ,  CLARK RICHARD

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：PE05222002A1

公开(公告)日：2002-06-25

申请号：PE0010212001

申请日：2001-10-15

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: SE REFIERE A DERIVADOS DE ERITROMICINA (CETOLIDOS 6-O-SUSTITUIDOS) DE FORMULA I DONDE A1 ES ARILO, HETEROARILO; Y1 ES ISOXAZOL, OXAZOL, ISOTIAZOL, DIHIDROISOXAZOL, DIHIDROOXAZOL; D1 ES HC-CH; C C; R1 ES H, Rp; Rp ES UN GRUPO PROTECTOR DE OH. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS SIN PRODUCIR EL EFECTO COLATERAL DE INTOLERANCIA INTESTINAL COMO NAUSEAS, VOMITOS

公开(公告)号：CA2483220A1

公开(公告)日：2003-11-06

申请号：CA2483220

申请日：2003-04-23

Applicant: ABBOTT LAB

Inventor： FLORJANCIC ALAN S ,  DJURIC STEVAN ,  MA ZHENKUN ,  GU YUGUI ,  YONG HONG

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07D407/12

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

公开(公告)号：UY26964A1

公开(公告)日：2002-06-20

申请号：UY26964

申请日：2001-10-12

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  ZHANG SOUMING ,  PHAN LY TAM ,  DJURIC STEVAN ,  CLARK RICK F

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

Abstract: Compuestos de fórmula I son útiles para el tratamiento de infeciones bacterianas pero sin producir el efecto colateral de intolerancia gastrointestinal. También se revelan composiciones que contienen los compuestos y métodos de tratamiento que los utilizan.