公开(公告)号：CA2368768A1

公开(公告)日：2001-01-04

申请号：CA2368768

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： CONDON STEPHEN ,  CHANG SOU-JEN ,  DEMATTEI JOHN J ,  WITTENBERGER STEVEN J ,  PATEL HEMANT H ,  KING STEVEN A ,  PATEL SUBHASH R ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  ALLEN MICHAEL S ,  KOLACZKOWSKI LAWRENCE ,  PLATA DANIEL J ,  PREMCHANDRAN RAMIYA H

IPC: C07C68/06 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08 ,  C07C33/03 ,  C07C57/04 ,  C07C269/06 ,  C07C271/12 ,  C07C47/22 ,  C07C43/303 ,  C07C69/96

Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs meta l- catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.

公开(公告)号：PT1192139E

公开(公告)日：2012-07-20

申请号：PT00942823

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： KOLACZKOWSKI LAWRENCE ,  CHANG SOU-JEN ,  PLATA DANIEL J ,  STONER ERIC J ,  ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  KING STEVEN A ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

公开(公告)号：CA2309255C

公开(公告)日：2008-05-20

申请号：CA2309255

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： DONG XIAOXING ,  COPP RICHARD R JR ,  HENGEVELD JOHN E ,  PREMCHANDRAN RAMIYA H ,  GUPTA ASHOK K

IPC: C07H17/08 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'- amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9- anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：AU784291B2

公开(公告)日：2006-03-02

申请号：AU5739300

申请日：2000-06-15

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07D215/14 ,  C07C33/03 ,  C07C43/303 ,  C07C47/22 ,  C07C57/04 ,  C07C68/06 ,  C07C69/96 ,  C07C269/06 ,  C07C271/12 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：DK1032580T3

公开(公告)日：2004-08-02

申请号：DK98958010

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： HENGEVELD JOHN E ,  DONG XIAOXING ,  GUPTA ASHOK K ,  COPP RICHARD R JR ,  PREMCHANDRAN RAMIYA H

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'-amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.

公开(公告)号：HK1047089A1

公开(公告)日：2003-02-07

申请号：HK02107126

申请日：2002-09-26

Applicant: ABBOTT LAB

Inventor： ALLEN MICHAEL S ,  PREMCHANDRAN RAMIYA H ,  CHANG SOU-JEN ,  CONDON STEPHEN ,  DEMATTEI JOHN J ,  KING STEVEN A ,  KOLACZKOWSKI LAWRENCE ,  MANNA SUKUMAR ,  NICHOLS PAUL J ,  PATEL HEMANT H ,  PATEL SUBHASH R ,  PLATA DANIEL J ,  STONER ERIC J ,  TIEN JIEN-HEH J ,  WITTENBERGER STEVEN J

IPC: C07C20060101 ,  C07C68/06 ,  C07D20060101 ,  C07D215/14 ,  C07D215/18 ,  C07D401/12 ,  C07H17/08

Abstract: The invention relates to a process for preparing carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or a substrate that can be reduced to obtain the same. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 -CH=CHCH 2 OC(O)-X-R 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)

公开(公告)号：CA2309255A1

公开(公告)日：1999-05-27

申请号：CA2309255

申请日：1998-11-17

Applicant: ABBOTT LAB

Inventor： GUPTA ASHOK K ,  PREMCHANDRAN RAMIYA H ,  HENGEVELD JOHN E ,  DONG XIAOXING ,  COPP RICHARD R JR

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Disclosed is an improved and efficient process for N-desmethylating the 3'amino nitrogen of erythromycins and for converting the 3'-N-desmethylated erythromycins into 3'-N-substituted derivatives of 8,9-anhydro-erythromycin 6,9-hemiketals.