公开(公告)号：CA2698384A1

公开(公告)日：1998-06-18

申请号：CA2698384

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D205/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：DE69331329T2

公开(公告)日：2002-08-08

申请号：DE69331329

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：DK0663912T3

公开(公告)日：2002-04-15

申请号：DK93923826

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  C07D453/02

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：DE69331329D1

公开(公告)日：2002-01-24

申请号：DE69331329

申请日：1993-10-08

Applicant: ABBOTT LAB

Inventor： ABREO MELWYN A ,  GUNN DAVID E ,  LIN NAN-HORNG ,  ELLIOTT RICHARD L ,  GARVEY DAVID S ,  LEBOLD SUZANNE A ,  WASICAK JAMES T

IPC: A61K31/427 ,  A61K31/439 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P25/00 ,  A61P25/28 ,  C07D401/12 ,  C07D403/12 ,  C07D411/12 ,  C07D417/12 ,  C07D471/08 ,  C07D487/04 ,  A61K31/425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

公开(公告)号：AU733881B2

公开(公告)日：2001-05-31

申请号：AU5601098

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：HK1026416A1

公开(公告)日：2000-12-15

申请号：HK00104266

申请日：2000-07-11

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  C07D ,  A61K

Abstract: 7a-Substituted hexahydro-1H-pyrrolizine compounds having the formula wherein A is a defined heterocycle moiety, pharmaceutical compositions of these compounds, and use of said compositions to selectively control synaptic transmission in mammals.

公开(公告)号：CZ9902048A3

公开(公告)日：2000-01-12

申请号：CZ204899

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHAN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B

IPC: A61K31/44 ,  A61P25/04 ,  C07D205/04 ,  C07D401/12

公开(公告)号：ZA9801301B

公开(公告)日：1998-08-28

申请号：ZA9801301

申请日：1998-02-17

Applicant: ABBOTT LAB

Inventor： WASICAK JAMES T ,  GARVEY DAVID S ,  HOLLADAY MARK W ,  LIN NAN-HORNG ,  RYTHER KEITH B

IPC: A61P25/04 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4725 ,  A61P25/00 ,  A61P43/00 ,  C07D487/04 ,  C07D ,  A61K

CPC classification number: C07D487/04

公开(公告)号：AU5601098A

公开(公告)日：1998-07-03

申请号：AU5601098

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  A61K31/44

Abstract: The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula (I) which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

公开(公告)号：CA2698384C

公开(公告)日：2012-05-01

申请号：CA2698384

申请日：1997-12-10

Applicant: ABBOTT LAB

Inventor： HOLLADAY MARK W ,  ARNERIC STEPHEN P ,  BAI HAO ,  DART MICHAEL J ,  LIN NAN-HORNG ,  LYNCH JOHN K ,  OR YAT SUN ,  RYTHER KEITH B ,  SULLIVAN JAMES P ,  WASICAK JAMES T ,  EHRLICH PAUL P

IPC: A61P25/04 ,  C07D205/04 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/485 ,  A61P25/28 ,  A61P29/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14

Abstract: The invention relates to an azetidine compound of formula (see formula II) or (see formula III) involved in the preparation of selected compounds of formula (1) (see formula I) or a pharmaceutically acceptable salt thereof.